Results 71 to 80 of about 249,034 (202)
Cancer metabolism at a glance [PDF]
, 2016 A defining hallmark of cancer is uncontrolled cell proliferation. This is initiated once cells have accumulated alterations in signaling pathways that control metabolism and proliferation, wherein the metabolic alterations provide the energetic and ...
Gottlieb, Eyal +5 more
core +2 more sources
Remnants of an ancient metabolism without phosphate [PDF]
, 2017 Phosphate is essential for all living systems, serving as a building block of genetic and metabolic machinery. However, it is unclear how phosphate could have assumed these central roles on primordial Earth, given its poor geochemical accessibility.
Goldford, Joshua E. +3 more
core +1 more source
TCA Cycle Defects and Cancer: When Metabolism Tunes Redox State
International Journal of Cell Biology, 2012 Inborn defects of the tricarboxylic acid (TCA) cycle enzymes have been known for more than twenty years. Until recently, only recessive mutations were described which, although resulted in severe multisystem syndromes, did not predispose to cancer onset.
Simone Cardaci, Maria Rosa Ciriolo
doaj +1 more source
Journal of Lipid Research, 2012 The manner in which insulin resistance impinges on hepatic mitochondrial function is complex. Although liver insulin resistance is associated with respiratory dysfunction, the effect on fat oxidation remains controversial, and biosynthetic pathways that ...
Santhosh Satapati +9 more
doaj +1 more source
Cell & Bioscience, 2022 Background One of coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused coronavirus disease 2019 (COVID-19) pandemic and threatened worldwide.
Sang R. Lee +4 more
doaj +1 more source
The balance between fumarate and malate plays an important role in plant development and postharvest quality in tomato fruit [PDF]
, 2018 Organic acids, produced as intermediates of the tricarboxylic cycle, play a crucial role in the plant primary metabolism and are considered as being ones of the most important quality traits in edible fruits.
Fernie, Alisdair R +5 more
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Minimizing acetate formation in E. coli fermentations [PDF]
, 2007 Escherichia coli remains the best established production organisms in industrial biotechnology. However, during aerobic fermentation runs at high growth rates, considerable amounts of acetate are accumulated as by-product.
De Maeseneire, Sofie +3 more
core +2 more sources
Metabolic Effects of the Cancer Metastasis Modulator MEMO1
MetabolitesBackground/Objectives: Cancer cells often display altered energy metabolism. In particular, expression levels and activity of the tricarboxylic acid cycle (TCA cycle) enzymes may change in cancer, and dysregulation of the TCA cycle is a frequent hallmark
Marziyeh Ghanbarian +6 more
doaj +1 more source
The Hepatocellular Hypoxia Criteria:2’Nitroimidazole Effect on Hepatocyte Carbohydrate Metabolizing Enzymes [PDF]
, 2008 Aim: to understand the 2’-nitroimidazole induced hypoxia and liver cell interaction, we proposed a “Hapatocellular Hypoxia Criteria”.
Rakesh Sharma
core +1 more source
Central metabolism in during the transition from O-rich to O-poor conditions as studied by isotopomer-assisted metabolite analysis [PDF]
, 2009 Isotopomer-assisted metabolite analysis was used to investigate the central metabolism of Mycobacterium smegmatis and its transition from normal growth to a non-replicating state under a hypoxic environment. Tween 80 significantly promoted aerobic growth
Yinjie J. Tang +24 more
core +3 more sources