Results 101 to 110 of about 146,987 (295)
Advanced Science, EarlyView.YAP undergoes phase separation to activate the AJUBA super‐enhancer, driving aberrant mitosis through spindle checkpoint dysregulation in breast cancer. This study uncovers a mechanistic link between YAP condensates, super‐enhancer activation, and aneuploidy formation.
Rui Zhang +8 more
wiley +1 more source
EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer
Advanced Science, EarlyView.This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv +8 more
wiley +1 more source
Exploration of Combinational Therapeutic Strategies for HCC Based on TCGA HCC Database [PDF]
, 2022 Dong Yan +6 more
openalex +1 more source
Advanced Science, EarlyView.ABSTRACT Multiple myeloma (MM) is a hematologic malignancy driven by clonal expansion of malignant plasma cells. Despite the long‐term disease control achieved with immunotherapies in some patients, treatment resistance remains a major cause of disease relapse.
Huiyao Gu +15 more
wiley +1 more source
Advanced Science, EarlyView.The SNARE protein YKT6 is upregulated in bladder cancer (BLCA), correlating with poor prognosis. YKT6 promotes tumor proliferation and metastasis by activating Wnt/β‐catenin signaling. It recruits Ubiquitin‐Specific Peptidase 7 (USP7) to deubiquitinate and stabilize β‐catenin, enhancing its nuclear accumulation and driving oncogenic gene expression ...
Sheng Tu +16 more
wiley +1 more source
Processing TCGA mRNA expression data
, 2015 Handout for workshop on TCGA data analysis.
openaire +1 more source
Advanced Science, EarlyView.PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li +17 more
wiley +1 more source
Construction of a Prognostic Signature of 10 Autophagy-Related lncRNAs in Gastric Cancer
International Journal of General Medicine, 2022 Wenwen Wang,1,2 Qingshan Pei,1 Lifen Wang,1 Tong Mu,1 Hua Feng1 1Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, People’s Republic of China; 2Shandong Provincial Engineering ...
Wang W, Pei Q, Wang L, Mu T, Feng H
doaj
Identification of methylation driven biomarkers for diagnosis and prognosis in colorectal cancer by Integrative Analysis of TCGA, GTEx, and GEO database [PDF]
, 2022 Lichao Cao +5 more
openalex +1 more source