Results 101 to 110 of about 184,470 (334)

Integrated analysis of lymphocyte infiltration-associated lncRNA for ovarian cancer via TCGA, GTEx and GEO datasets

PeerJ, 2020
Background Abnormal expression of long non-coding RNAs (lncRNA) play a significant role in the incidence and progression of high-grade serous ovarian cancer (HGSOC), which is a leading cause of mortality among gynecologic malignant tumor patients.
Meijing Wu, X. Shang, Yue Sun, Jing Wu, Guoyan Liu   +4 more
semanticscholar   +1 more source

Construction and Verification of a Hypoxia-Related 4-lncRNA Model for Prediction of Breast Cancer

International Journal of General Medicine, 2021
Ye Zhao,1,* Lixiao Liu,1,* Jinduo Zhao,1 Xuedan Du,2 Qiongjie Yu,2 Jinting Wu,2 Bin Wang,2 Rongying Ou1 1Department of Obstetrics and Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of
Zhao Y, Liu L, Zhao J, Du X, Yu Q, Wu J, Wang B, Ou R   +7 more
doaj  

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Screening and Identifying Immune-Related Cells and Genes in the Tumor Microenvironment of Bladder Urothelial Carcinoma: Based on TCGA Database and Bioinformatics

Frontiers in Oncology, 2020
Bladder cancer is the most common cancer of the urinary system and its treatment has scarcely progressed for nearly 30 years. Advances in checkpoint inhibitor research have seemingly provided a new approach for treatment.
Jinlong Cao, Xin Yang, Jianpeng Li, Hao Wu, Pan Li, Z. Yao, Zhichun Dong, Junqiang Tian   +7 more
semanticscholar   +1 more source

An integrated prognostic model of nuclear-encoded mitochondrial gene signature and clinical information for hepatocellular carcinoma

Shanghai Jiaotong Daxue xuebao. Yixue ban
Objective·To establish a prognostic model for the overall survival (OS) of hepatocellular carcinoma (HCC) based on mitochondrial genes and clinical information.Methods·The gene expression and the clinical data of 369 HCC patients and 50 controls with ...
Kedeerya Aishanjiang, FU Yi, LAI Donglin, WU Hailong, GONG Wei   +4 more
doaj   +1 more source

Comprehensive Analysis of the E2F Transcription Factor Family in Human Lung Adenocarcinoma

International Journal of General Medicine, 2022
Qixun Wang,1,* Jinping Liu,1,* Iokfai Cheang,2,* Jinghang Li,3 Tingzhen Chen,4 Yanxiu Li,4 Bo Yu1 1Department of Cardiovascular Surgery, The First People’s Hospital of Lianyungang, Lianyungang Clinical College of Nanjing Medical University ...
Wang Q, Liu J, Cheang I, Li J, Chen T, Li Y, Yu B   +6 more
doaj  

A Bayesian graphical model for integrative analysis of TCGA data [PDF]

Proceedings 2012 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS), 2012
We integrate three TCGA data sets including measurements on matched DNA copy numbers (C), DNA methylation (M), and mRNA expression (E) over 500+ ovarian cancer samples. The integrative analysis is based on a Bayesian graphical model treating the three types of measurements as three vertices in a network.
Jie Zhang, Yanxun Xu, Riten Mitra, Yuan Yuan, Peter Müller, Yuan Ji   +5 more
openaire   +3 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Screening and Identification of Key Biomarkers for Bladder Cancer: A Study Based on TCGA and GEO Data

BioMed Research International, 2020
Bladder cancer (BLCA) is a common malignant cancer, and it is the most common genitourinary cancer in the world. The recurrence rate is the highest of all cancers, and the treatment of BLCA has only slightly improved over the past 30 years.
Yingkun Xu, Guangzhen Wu, Jianyi Li, Jiatong Li, Ningke Ruan, Liye Ma, Xiaoyang Han, Yanjun Wei, Liang Li, Hongge Zhang, Yougen Chen, Q. Xia   +11 more
semanticscholar   +1 more source