Results 21 to 30 of about 146,987 (295)

A Bioinformatic Analysis of Immune-Related Prognostic Genes in Clear Cell Renal Cell Carcinoma Based on TCGA and GEO Databases

International Journal of General Medicine, 2022
Jianpeng Li,1– 3,* Jinlong Cao,1– 3,* Pan Li,1– 3 Ran Deng,1– 3 Zhiqiang Yao,1– 3 Lijun Ying,1– 3 Junqiang Tian1– 3 1Department of Urology, The Second Hospital of Lanzhou University, Lanzhou, People’s Republic of China; 2Key Laboratory of Gansu ...
Li J, Cao J, Li P, Deng R, Yao Z, Ying L, Tian J   +6 more
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Classification of non-TCGA cancer samples to TCGA molecular subtypes using compact feature sets [PDF]

Cancer Cell
Molecular subtypes, such as defined by The Cancer Genome Atlas (TCGA), delineate a cancer's underlying biology, bringing hope to inform a patient's prognosis and treatment plan. However, most approaches used in the discovery of subtypes are not suitable for assigning subtype labels to new cancer specimens from other studies or clinical trials. Here, we
Kyle Ellrott, Christopher K. Wong, Christina Yau, Mauro A.A. Castro, Jordan A. Lee, Brian J. Karlberg, Jasleen K. Grewal, Vincenzo Lagani, Bahar Tercan, Verena Friedl, Toshinori Hinoue, Vladislav Uzunangelov, Lindsay Westlake, Xavier Loinaz, Ina Felau, Peggy I. Wang, Anab Kemal, Samantha J. Caesar-Johnson, Ilya Shmulevich, Alexander J. Lazar, Ioannis Tsamardinos, Katherine A. Hoadley, A. Gordon Robertson, Theo A. Knijnenburg, Christopher C. Benz, Joshua M. Stuart, Jean C. Zenklusen, Andrew D. Cherniack, Peter W. Laird   +28 more
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Construction and Verification of a Hypoxia-Related 4-lncRNA Model for Prediction of Breast Cancer

International Journal of General Medicine, 2021
Ye Zhao,1,* Lixiao Liu,1,* Jinduo Zhao,1 Xuedan Du,2 Qiongjie Yu,2 Jinting Wu,2 Bin Wang,2 Rongying Ou1 1Department of Obstetrics and Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of
Zhao Y, Liu L, Zhao J, Du X, Yu Q, Wu J, Wang B, Ou R   +7 more
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Converging focal radiation and immunotherapy in a preclinical model of triple negative breast cancer: contribution of VISTA blockade

OncoImmunology, 2020
Antibodies targeting the co-inhibitory receptor programmed cell death 1 (PDCD1, best known as PD-1) or its main ligand CD274 (best known as PD-L1) have shown some activity in patients with metastatic triple-negative breast cancer (TNBC), especially in a ...
Karsten A. Pilones, Michal Hensler, Camille Daviaud, Jeffrey Kraynak, Jitka Fucikova, Lorenzo Galluzzi, Sandra Demaria, Silvia C. Formenti   +7 more
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Construction and validation of a novel prognostic signature for uveal melanoma based on five metabolism-related genes

Mathematical Biosciences and Engineering, 2021
Background: Uveal melanoma (UM) is the most aggressive intraocular tumor worldwide. Accurate prognostic models are urgently needed. The present research aimed to construct and validate a prognostic signature is associated with overall survival (OS) for ...
Han Zhao , Yun Chen, Peijun Shen, Lan Gong   +3 more
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Identifying the Antitumor Effects of Curcumin on Lung Adenocarcinoma Using Comprehensive Bioinformatics Analysis

Drug Design, Development and Therapy, 2022
Fei-Ran Yang,1,* Si-Yi Li,1,* Xi-Wen Hu,1 Xiu-Rong Li,2 Hui-Jie Li2 1College of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, People’s Republic of China; 2Department of Oncology, Affiliated ...
Yang FR, Li SY, Hu XW, Li XR, Li HJ
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Mining TCGA Data Using Boolean Implications

PLoS ONE, 2014
Boolean implications (if-then rules) provide a conceptually simple, uniform and highly scalable way to find associations between pairs of random variables. In this paper, we propose to use Boolean implications to find relationships between variables of different data types (mutation, copy number alteration, DNA methylation and gene expression) from the
Sinha, Subarna, Tsang, Emily K., Zeng, Haoyang, Meister, Michela, Dill, David L.   +4 more
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Identification and Validation of an Endoplasmic Reticulum Stress-Related lncRNA Signature for Colon Adenocarcinoma Patients

International Journal of General Medicine, 2022
Xueru Chen,1,* Kai Gao,2,* Zijin Xiang,1 Yujun Zhang,1 Xiangdong Peng1 1Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, People’s Republic of China; 2Department of Gastrointestinal Surgery ...
Chen X, Gao K, Xiang Z, Zhang Y, Peng X
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lncRNA EGOT across cancers: TCGA analysis [PDF]

Archives of Medical Science
Introductionlong-non-coding RNAs (lncRNAs) are important new players in the epigenetic control of cellular phenotypes. One of the lncRNAs is the eosinophil granule ontogeny transcript (EGOT), in which changes in expression levels are correlated with pathological conditions, including tumorigenesis and viral infections.
Tomasz Kolenda, Joanna Kozłowska-Masłoń, Kacper Guglas, Piotr Białas, Patrycja Mantaj, Paulina Poter, Anna Florczak, Anna Zapłata, Anna Malicka-Durczak, Dominika Połczyńska-Hałas, Małgorzata Nowak, Marlena Janiczek-Polewska, Anna Przybyła, Zefiryn Cybulski, Ewa Leporowska, Dariusz Iżycki, Joanna Kaźmierska   +16 more
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Identification of Gene-Environment Interactions by Non-Parametric Kendall’s Partial Correlation with Application to TCGA Ultrahigh-Dimensional Survival Genomic Data

Frontiers in Bioscience-Landmark, 2022
Background: In biomedical and epidemiological studies, gene-environment (G-E) interactions play an important role in the etiology and progression of many complex diseases.
Jie-Huei Wang, Chun-Ting Yang
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