Results 141 to 150 of about 156,157 (263)

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Structural T-Cell Receptor Analysis in the Age of Machine Learning. [PDF]

Immunol Rev
Quast NP, Raybould MIJ, Deane CM.
europepmc   +1 more source

A Tripartite Model for EBV‐Driven Multiple Sclerosis: B Cell Survival, Altered Self‐Presentation, and HLA‐DR15‐Restricted T Cell Cross‐Reactivity

iNew Medicine, EarlyView.
ABSTRACT This commentary integrates findings from three recent Cell reports to establish a unified mechanistic model of multiple sclerosis (MS) driven by the interplay between Epstein‐Barr virus (EBV) and the HLA‐DR15 genotype. EBV promotes CNS autoimmunity through three distinct but intersecting mechanisms.
Fang Zhu, Arnaud John Kombe Kombe, Tengchuan Jin   +2 more
wiley   +1 more source

Retrohepatic Vena Cava Encirclement, as Surrogate of Extensive Liver Manipulation During Caval Sparing Hepatectomy, Is a Risk Factor for Tumor Recurrence After Liver Transplantation for Hepatocellular Carcinoma

Journal of Surgical Oncology, EarlyView.
ABSTRACT Introduction In liver transplantation (LT) with a caval sparing (CS) approach, the presence of complete encirclement of inferior vena cava (IVC‐E) by hypertrophic segment 1 increases the technical complexity of hepatectomy. Thus, in LT for hepatocellular carcinoma (HCC), It may be suspected that the resulting greater liver manipulation and ...
Riccardo Pravisani, Claudio Bosio, Grazia Conte, Alex Borin, Amedeo Carraro, Federico Mocchegiani, Maria De Martino, Marco Vivarelli, Dario Lorenzin, Umberto Baccarani   +9 more
wiley   +1 more source

Mechanical axis correction after total knee arthroplasty alters ankle alignment but does not affect ankle function

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Total knee arthroplasty (TKA) restores knee function, but correction of coronal plane deformities may alter the biomechanics of adjacent joints. This study aimed to determine whether changes in knee alignment after TKA have clinical or radiological effects on the ankle.
Alba Portes‐Chiva, Ana Soria‐Blázquez, Pedro Hinarejos, Raul Torres‐Claramunt, Simone Perelli, Juan‐Francisco Sánchez‐Soler, Alberto Ginés‐Cespedosa, Juan‐Carlos Monllau   +7 more
wiley   +1 more source

Integrative scRNA-seq and scTCR-seq analyses decode dual TCR γδ T-cell characteristics in human and mouse. [PDF]

Immunohorizons
Wang H, Xu Y, Cao N, Ma Q, Li J, Quan K, Yao X.   +6 more
europepmc   +1 more source

Adoptive T Cell therapy for cancer and autoimmune disease: current advances, challenges, and future directions. [PDF]

Oncol Rev
Bao QH, Wu A, Pang J, Wang J, Chen Q, Wu S.   +5 more
europepmc   +1 more source

AI Companions and Loneliness: Conceptualizing and Operationalizing Synthetic Mindfulness and Exploring Its Role in Alleviating Loneliness

Psychology &Marketing, EarlyView.
ABSTRACT The rise of AI companions has sparked interest in their potential to alleviate the growing social problem of loneliness, yet evidence of their effectiveness remains unsettled. Drawing on social surrogacy theory with a theories‐in‐use approach, this research introduces synthetic mindfulness, defined as consumers' judgment of an AI companion's ...
Varqa Shamsi Bahar, Artyom Golossenko, Sumin Kim, Matti Jaakkola   +3 more
wiley   +1 more source

Minor histocompatibility antigen TCR-T. [PDF]

Blood Adv
Krakow EF, Bleakley M.
europepmc   +1 more source

SERPINB9 Promotes Colorectal Cancer Liver Metastasis and Immunotherapy Resistance: Association With MHC‐I Downregulation and CD8+ T Cell Dysfunction

Medicine Bulletin, EarlyView.
ABSTRACT Background Colorectal cancer liver metastasis (CRLM) is the leading cause of mortality in colorectal cancer (CRC) patients, for which effective treatments remain limited. The mechanisms by which tumor cells evade immune surveillance and escape cytotoxic killing remain poorly understood.
Xin Liu, Wenchen Wang, Hongqian Wang, Yanshen Kuang, Baoqing Jia   +4 more
wiley   +1 more source