Results 151 to 160 of about 156,157 (263)

A Pilot Study of Brain Metabolites and Their Diagnostic Cutoff Point in Postmenopausal Women With Cognitive Impairment Using Magnetic Resonance Spectroscopy. [PDF]

NMR Biomed
Chen X, Lu Y, Tang L, Mai W, Qin Y, Li T, Huang Y, Meng J, Zou Z, Zhao L.   +9 more
europepmc   +1 more source

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source

T-Cell Receptor Single-Chain Antibody IgG1-Fc Fusion Proteins as Bispecific Engagers for Natural Killer and T Cells. [PDF]

Cells
Teschner AC, Gonçalves M, Meyer M, Zörnig I, Jäger D, Momburg F.   +5 more
europepmc   +1 more source

Organoid Coculture Models for Cancer Research and Immunotherapy

Med Research, EarlyView.
This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen   +9 more
wiley   +1 more source

Comparing Multi‐Pool Lorentzian Fitting Methods for Guanidinium CEST Quantification in the Human Brain at Clinical 3 T: A Validation Study Using MRS

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose This study aimed to evaluate the performance of our recently proposed double‐step multi‐pool Lorentzian fitting (DMPLF) method for extracting GuanCEST and other CEST signals in the human brain at clinical 3 T, using MRS as the reference standard.
Ziyan Wang, Huabin Zhang, Jiawen Wang, Ying Zhang, Jianpan Huang   +4 more
wiley   +1 more source

A structured multidisciplinary home parenteral nutrition program in a public healthcare system: Implementation model, nursing‐led training protocol, and 11‐year safety outcomes

Nutrition in Clinical Practice, EarlyView.
Abstract Background Home parenteral nutrition (HPN) is the standard of care for adults with chronic intestinal failure (CIF), but evidence from publicly funded healthcare systems in middle‐income countries is limited. This study describes an 11‐year experience of a structured, nursing‐led HPN program within Brazil's Unified Health System (SUS ...
Tatiana da Cunha Rana, Mariana Hollanda Martins da Rocha, Luiz Augusto Carneiro d'Albuquerque, André Dong Won Lee, Wellington Andraus, Luciana Bertocco de Paiva Haddad   +5 more
wiley   +1 more source

Molecular, spatial, and AI‐enabled technologies for predicting neoadjuvant therapy response in locally advanced rectal cancer

The Journal of Pathology, EarlyView.
Abstract Pretreatment prediction of neoadjuvant response remains an unresolved challenge in locally advanced rectal cancer, where management is moving towards risk‐adapted and response‐oriented treatment strategies. Prediction remains difficult because response reflects interacting tumour‐intrinsic, immune, stromal, and spatial processes that are ...
Gina F Boot, Cibele Masotti, Claudia Corrò, Cédric Schraepen, Hannah L Williams, Thomas A Wright, Fiza Ishaqwala, Colin W Steele, Gertjan Rasschaert, Maxime W Lafarge, Enric Domingo, Inti Zlobec, Rodrigo Oliva Perez, Campbell SD Roxburgh, Timothy S Maughan, Sabine Tejpar, Thibaud Koessler, Viktor H Koelzer   +17 more
wiley   +1 more source

Immune signatures of common exposures through co-occurrence of T-cell receptors in tens of thousands of donors. [PDF]

Front Immunol
May DH, Woodhouse S, Noakes MT, Doroschak K, Elyanow R, Moore AJ, Osborne EJ, Greenfield B, Hayes T, Taniguchi R, Yang Z, Grino JR, Byron R, Oaks J, Chen-Harris H, Sherwood A, Greissl J, Howie B, Klinger M, Robins HS.   +19 more
europepmc   +1 more source

Naïve adaptive immune receptor repertoires in celiac disease assessed by machine learning; impact of the HLA-DQ2.5 allotype on the TCR repertoire. [PDF]

Immunogenetics
Officer A, Lindeman I, Pavlovic M, Lund-Andersen C, Ness-Jensen E, Sandve GK, Sollid LM.   +6 more
europepmc   +1 more source

Innovative technologies for gait rehabilitation in incomplete spinal cord injury: A systematic review and meta‐analysis

PM&R, EarlyView.
Abstract Objective This systematic review and meta‐analysis aimed to synthesize the current evidence on the efficacy of various technological interventions for gait rehabilitation in adults with incomplete spinal cord injury (iSCI). Literature survey MEDLINE (accessed by PubMed), Embase, Cochrane Central Register of Controlled Trials (Cochrane CENTRAL),
Emerson de Carvalho, Thainara Cruz da Rosa, Maira Jaqueline da Cunha, Aline S. Pagnussat   +3 more
wiley   +1 more source