Results 171 to 180 of about 156,157 (263)

S-ketamine dampens effector T-cell function, thereby promoting tumor progression. [PDF]

Front Immunol
Niu D, Wang L, Wei R, Yao L.
europepmc   +1 more source

The Socio‐Economic Benefits of Communal Trophy Hunting in Africa: A Value Chain Perspective From Namibia

Sustainable Development, EarlyView.
ABSTRACT International concerns around the equitable distribution of income generated by communal trophy hunting tourism have raised questions about the industry's effectiveness in promoting rural livelihoods and nature conservation. We examine how communities in Namibia derive benefits from wildlife and explore local perspectives on fostering active ...
Luke Symonds‐Mayes, Enrico Di Minin, Hayley Clements   +2 more
wiley   +1 more source

LAT condensation gates PLCγ1 activation via bimodal LAT phosphorylation. [PDF]

Proc Natl Acad Sci U S A
Ren H, Lee HR, Omar YAD, DeGrandchamp JB, Hung CL, Eisen TJ, Stamou D, Kuriyan J, Chakraborty AK, Groves JT.   +9 more
europepmc   +1 more source

A Triangulenum‐Based Biosensor Platform for Mapping Kinase Activity in T Cells

Small, EarlyView.
Novel peptide biosensors based on long‐lifetime triangulenium dyes are developed for the real‐time, non‐invasive mapping of Akt1 and Src kinase activities in living cells. Utilizing FLIM microscopy, these highly specific, biocompatible probes overcome cellular autofluorescence.
Carmen Salto‐Giron, Angélica Martín‐Priego, Francisco Fueyo‐González, María Mar Quesada‐Moreno, Federico Movilla, Antonio Reinoso, Laura Espinar‐Barranco, Rafael Salto, Amparo Navarro, Miguel Fribourg, Angel Orte, Juan A. González‐Vera   +11 more
wiley   +1 more source

Mechano‐Chemical Coordination of Nanoparticle‐Based Artificial Antigen‐Presenting Cells Synergistically Tunes T Cell Activation and Expansion Phenotypes

Small, EarlyView.
Mechanically distinct nano artificial antigen‐presenting cells with independently controlled antibody density are used to reveal how physical and biochemical cues jointly regulate human T‐cell activation. Increasing stiffness and antibody density accelerates activation, enhances expansion, and promotes effector‐associated differentiation, whereas ...
Zichao Guo, Fei Hou, Yali Zhang, Zilin Ye, Yang Li, Supun Ranaweera, Yue Hui, Chun‐Xia Zhao   +7 more
wiley   +1 more source

The Thymic Microenvironment Shapes Age-Related Qualitative Changes in the TCR Repertoire. [PDF]

Aging Cell
Rowell J, Yanez DC, Ross S, Lau CI, Zhang E, Monfared A, Peña OA, Chain B, Crompton T.   +8 more
europepmc   +1 more source

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source