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Blood, 2009
In this issue of Blood, Burns and colleagues analyzed samples from 18 patients with melanoma, treated with T lymphocytes gene-modified to express a tumor-specific TCR. Results show persistence of transduced cells, but early shutdown of TCR gene expression.
BONINI , MARIA CHIARA, Russo V.
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In this issue of Blood, Burns and colleagues analyzed samples from 18 patients with melanoma, treated with T lymphocytes gene-modified to express a tumor-specific TCR. Results show persistence of transduced cells, but early shutdown of TCR gene expression.
BONINI , MARIA CHIARA, Russo V.
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RhoH modulates pre-TCR and TCR signalling by regulating LCK
Cellular Signalling, 2011Pre-T-cell receptor (pre-TCR) and TCR signals govern the development of T-lymphocytes. RhoH, a hematopoietic-specific and GTPase-deficient member of the RhoGTPase family, is required in the development of T-lymphocytes. Here we found that RhoH binds and modulates LCK, the non-receptor tyrosine kinase crucial in initiating pre-TCR and TCR signallings ...
Hong, Wang +3 more
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Science's STKE, 2007
The Rho family guanosine triphosphatase Rac regulates the actin cytoskeleton and microtubule dynamics. Tanaka et al . investigated a role for Dock2, a guanine nucleotide exchange factor and activator of Rac in the regulation of CD4 + T cell differentiation.
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The Rho family guanosine triphosphatase Rac regulates the actin cytoskeleton and microtubule dynamics. Tanaka et al . investigated a role for Dock2, a guanine nucleotide exchange factor and activator of Rac in the regulation of CD4 + T cell differentiation.
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Science Signaling, 2008
The exact mechanism by which peptide-loaded major histocompatibility complex (pMHC) activates the T cell receptor (TCR) has been controversial. Various models have been proposed to account for the requirement of presentation by antigen-presenting cells (APCs) for effective TCR activation and the lack of activation by soluble pMHC, the ...
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The exact mechanism by which peptide-loaded major histocompatibility complex (pMHC) activates the T cell receptor (TCR) has been controversial. Various models have been proposed to account for the requirement of presentation by antigen-presenting cells (APCs) for effective TCR activation and the lack of activation by soluble pMHC, the ...
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Journal of immunology (Baltimore, Md. : 1950), 2000
During alphabeta T cell development, CD4(-)CD8(-) thymocytes first express pre-TCR (pTalpha/TCR-beta) before their differentiation to the CD4(+)CD8(+) stage. Positive selection of self-tolerant T cells is then determined by the alphabeta TCR expressed on CD4(+)CD8(+) thymocytes. Conceivably, an overlap in surface expression of these two receptors would
S, Trop +4 more
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During alphabeta T cell development, CD4(-)CD8(-) thymocytes first express pre-TCR (pTalpha/TCR-beta) before their differentiation to the CD4(+)CD8(+) stage. Positive selection of self-tolerant T cells is then determined by the alphabeta TCR expressed on CD4(+)CD8(+) thymocytes. Conceivably, an overlap in surface expression of these two receptors would
S, Trop +4 more
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Science Signaling, 2012
Engineering nonimmune cells with components of the T cell receptor signaling system enables the interaction with antigen-presenting cells to initiate T cell receptor activation.
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Engineering nonimmune cells with components of the T cell receptor signaling system enables the interaction with antigen-presenting cells to initiate T cell receptor activation.
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TCR Recognition of Peptide–MHC-I: Rule Makers and Breakers
International Journal of Molecular Sciences, 2021Stephanie Gras +2 more
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