Human TCR repertoire in cancer [PDF]
Cancer MedicineBackground T cells, the “superstar” of the immune system, play a crucial role in antitumor immunity. T‐cell receptors (TCR) are crucial molecules that enable T cells to identify antigens and start immunological responses.
Lin Chen +4 more
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Machine Learning Approaches to TCR Repertoire Analysis. [PDF]
Front Immunol, 2022 Sparked by the development of genome sequencing technology, the quantity and quality of data handled in immunological research have been changing dramatically. Various data and database platforms are now driving the rapid progress of machine learning for immunological data analysis.
Katayama Y +3 more
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TIRTL-seq: deep, quantitative and affordable paired TCR repertoire sequencing. [PDF]
Nat Methodsɑ/β T cells are key players in adaptive immunity. The specificity of T cells is determined by the sequences of the hypervariable T cell receptor (TCR) ɑ and β chains.
Pogorelyy MV +9 more
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Genetic and environmental determinants of human TCR repertoire diversity [PDF]
Immunity & Ageing, 2020 T cell discrimination of self and non-self is the foundation of the adaptive immune response, and is orchestrated by the interaction between T cell receptors (TCRs) and their cognate ligands presented by major histocompatibility (MHC) molecules. However,
Chirag Krishna +4 more
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TCR repertoire dynamics and their responses underscores dengue severity. [PDF]
iScienceDespite recognizing the immune response's role in dengue progression, the intricate dynamics of T cell receptor (TCR) variations across DENV infection severities remain elusive. This study addresses this gap by analyzing in-house generated RNA-seq data from 112 dengue patients with varying disease severities.
Khare K +4 more
europepmc +5 more sources
Numbers and odds: TCR repertoire size and its age changes impacting on T cell functions. [PDF]
Semin Immunol, 2023 A vast array of αβ T cell receptors (TCRs) is generated during T cell development in the thymus through V(D)J recombination, which involves the rearrangement of multiple V, D, and J genes and the pairing of α and β chains.
Weng NP.
europepmc +2 more sources
Evaluation of the TCR Repertoire as a Predictive and Prognostic Biomarker in Cancer: Diversity or Clonality? [PDF]
Cancers (Basel), 2022 Simple Summary The TCR is the T cell antigen receptor, and it is responsible of the T cell activation, through the HLA-antigen complex recognition.
Aran A +4 more
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End-Stage Renal Disease Causes Skewing in the TCR Vβ-Repertoire Primarily within CD8+ T Cell Subsets [PDF]
Frontiers in Immunology, 2017 A broad T cell receptor (TCR-) repertoire is required for an effective immune response. TCR-repertoire diversity declines with age. End-stage renal disease (ESRD) patients have a prematurely aged T cell system which is associated with defective T cell ...
Ling Huang +5 more
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The TCR repertoire of α-synuclein-specific T cells in Parkinson’s disease is surprisingly diverse
Scientific Reports, 2021 The self-antigen α-synuclein (α-syn) was recently shown to be associated with Parkinson’s disease (PD). Here we mapped the T cell receptor (TCR) repertoire of α-syn-specific T cells from six PD patients.
Akul Singhania +13 more
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Dynamics of TCR repertoire and T cell function in COVID-19 convalescent individuals. [PDF]
Cell Discov, 2021 SARS-CoV-2 outbreak has been declared by World Health Organization as a worldwide pandemic. However, there are many unknowns about the antigen-specific T-cell-mediated immune responses to SARS-CoV-2 infection.
Luo L +21 more
europepmc +2 more sources