Results 91 to 100 of about 272,710 (333)

Preselection TCR repertoire predicts CD4+ and CD8+ T‐cell differentiation state

Immunology, 2020
T cells must display diversity regarding both the cell state and T‐cell receptor (TCR) repertoire to provide effective immunity against pathogens; however, the generation and evolution of cellular T‐cell heterogeneity in the adaptive immune system ...
X. Hou, Wenbiao Chen, Xujun Zhang, Guangyu Wang, Jianing Chen, P. Zeng, Xuyan Fu, Qiong Zhang, Xiangdong Liu, Hongyan Diao   +9 more
semanticscholar   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

TCR Convergence in Individuals Treated With Immune Checkpoint Inhibition for Cancer. [PDF]

, 2019
Tumor antigen-driven selection may expand T cells having T cell receptors (TCRs) of shared antigen specificity but different amino acid or nucleotide sequence in a process known as TCR convergence. Substitution sequencing errors introduced by TCRβ (TCRB)
Conroy, Jeffrey, Fong, Lawrence, Looney, Timothy John, Lowman, Geoffrey, Morrison, Carl, Oh, David, Topacio-Hall, Denise, Zhang, Li   +7 more
core  

Distinct immune signatures in directly treated and distant tumors result from TLR adjuvants and focal ablation. [PDF]

, 2018
Both adjuvants and focal ablation can alter the local innate immune system and trigger a highly effective systemic response. Our goal is to determine the impact of these treatments on directly treated and distant disease and the mechanisms for the ...
Borowsky, Alexander D, Chavez, Michael, Davis, Ryan R, Ferrara, Katherine W, Fite, Brett Z, Hubbard, Neil E, Ilovitsh, Asaf, Ingham, Elizabeth S, Mahakian, Lisa M, Monjazeb, Arta M, Murphy, William J, Silvestrini, Matthew T, Tam, Sarah M, Tepper, Clifford G   +13 more
core   +1 more source

MAIT cells come to the rescue in cancer immunotherapy? [PDF]

, 2020
Recent progress in immunobiology has led to the observation that, among cells classically categorized as the typical representatives of the adaptive immune system, i.e., T cells, some possess the phenotype of innate cells.
Elewaut, Dirk, Venken, Koen, Łukasik, Zuzanna   +2 more
core   +2 more sources

Peripheral Blood TCR Repertoire Profiling May Facilitate Patient Stratification for Immunotherapy against Melanoma

Cancer immunology research, 2018
Analysis of TCR repertoire clonality in blood samples collected from patients with melanoma before treatment may predict their eventual response to anti-PD1 and anti-CTLA4 therapy.
S. Hogan, A. Courtier, P. Cheng, N. Jaberg-Bentele, S. Goldinger, Manuarii Manuel, Solène Perez, N. Plantier, J. Mouret, T. Nguyen-Kim, Marieke I. G. Raaijmakers, P. Kvistborg, N. Pasqual, J. Haanen, R. Dummer, M. Levesque   +15 more
semanticscholar   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection. [PDF]

, 2020
Mucosa-associated invariant T (MAIT) cell loss in chronic HIV-1 infection is a significant insult to antimicrobial immune defenses. Here we investigate the response of MAIT cells during acute HIV-1 infection utilizing the RV217 cohort with paired ...
Ananworanich, Jintanat, Bolton, Diane L, Costanzo, Margaret C, Creegan, Matthew, Dias, Joana, Eller, Leigh Anne, Eller, Michael A, Kibuuka, Hannah, Kim, Dohoon, Kosgei, Josphat, Krebs, Shelly J, Lal, Kerri G, Leeansyah, Edwin, Maganga, Lucas, Michael, Nelson L, Nitayaphan, Sorachai, Paquin-Proulx, Dominic, Phuang-Ngern, Yuwadee, Robb, Merlin L, Sacdalan, Carlo, Sandberg, Johan K, Schuetz, Alexandra, Shacklett, Barbara L, Slike, Bonnie M   +23 more
core  

Systematic Profiling of Full-Length Ig and TCR Repertoire Diversity in Rhesus Macaque through Long Read Transcriptome Sequencing

Journal of Immunology, 2020
Key Points PacBio Iso-Seq enables generation of immune repertoire C region references. Full-length CCS reads benchmark targeted immune repertoire assay efficiencies.
H. Brochu, Elizabeth Tseng, Elise A. Smith, Matthew J. Thomas, Aiden Jones, Kayleigh R. Diveley, Lynn Law, S. Hansen, L. Picker, M. Gale, Xinxia Peng   +10 more
semanticscholar   +1 more source

A Guide for Spatial Omics Technologies: Innovation, Evaluation, and Application

Advanced Science, EarlyView.
This review presents a strategy‐centric framework for spatial omics technologies, organizing methods by how spatial information is experimentally encoded. It compares key performance trade‐offs across sequencing‐ and imaging‐based approaches, examines computational and practical limitations, and highlights biomedical applications. The analysis provides
Xiaofeng Wu, Weize Xu, Da Lin, Leqiang Sun, Jinxia Dai, Gang Cao   +5 more
wiley   +1 more source