Results 151 to 160 of about 272,710 (333)

Positive selection determines T cell receptor V beta 14 gene usage by CD8+ T cells. [PDF]

open access: yes, 1989
We report here a mAb, 14-2, reactive with TCRs that include V beta 14. The frequency of V beta 14+ T cells varies with CD4 and CD8 subset and is controlled by the H-2 genes.
Liao, N, Maltzman, J, RAULET, David H.
core  

Major TCR Repertoire Perturbation by Immunodominant HLA-B*44:03-Restricted CMV-Specific T Cells

open access: yesFrontiers in Immunology, 2018
Lack of disease during chronic human cytomegalovirus (CMV) infection depends on the maintenance of a high-frequency CMV-specific T cell response.
Meriem Attaf   +11 more
semanticscholar   +1 more source

Single Cell Multi‐Omics Revealing the Important Role of MR1 Mediated MAIT Cells in Maintaining Rejection for Liver Transplantation

open access: yesCell Proliferation, EarlyView.
This multi‐omics study reveals the significant role of MAIT cells in liver transplant rejection. MAIT cells drive rejection in liver transplantation via the MR1 axis. Their absence reshapes T cell responses and clonal expansion, attenuating allograft injury.
Hailun Cai   +15 more
wiley   +1 more source

Globally shared TCR repertoires within the tumor-infiltrating lymphocytes of patients with metastatic gynecologic cancer [PDF]

open access: gold, 2023
Tae‐Hoon Kim   +7 more
openalex   +1 more source

The impact of accumulating immune adaptation in circulating strains of HIV‐1

open access: yesHIV Medicine, EarlyView.
Abstract Background Mutations in human immunodeficiency virus type 1 (HIV‐1) enable the virus to evade recognition and killing by human leucocyte antigen (HLA)‐restricted T cells. These viral adaptations are specific to the HLA type of individuals and are therefore evident as HLA allele‐HIV sequence associations at the population level. Most studies of
Marwah Al‐kaabi   +7 more
wiley   +1 more source

Memory TCR repertoires analyzed long-term reflect those selected during the primary response [PDF]

open access: yes, 2017
Normal T cell repertoire selection and evolution in antigen-specific responses is poorly understood. We have recently described an MHC class I-restricted response characterized by an overwhelming expansion of CD8 cells expressing a Vβ10 TCR, thus ...
Bucher, Philipp   +3 more
core  

The NF‐κB transcription factor RelA directs mucosal‐associated invariant T‐cell development

open access: yesImmunology &Cell Biology, EarlyView.
In this study, we found that the nuclear factor kappa light chain enhancer in activated B cells (NF‐κB) transcription factor RelA, and to a lesser extent NF‐κB1 and NF‐κB2, are key regulators of mucosal‐associated invariant T (MAIT)‐cell development and differentiation.
Thomas S Fulford   +15 more
wiley   +1 more source

Augmenting adaptive immunity: progress and challenges in the quantitative engineering and analysis of adaptive immune receptor repertoires

open access: yes, 2019
The adaptive immune system is a natural diagnostic and therapeutic. It recognizes threats earlier than clinical symptoms manifest and neutralizes antigen with exquisite specificity.
Abbas   +478 more
core   +1 more source

Weighting tumor-specific TCR repertoires as a classifier to stratify the immunotherapy delivery in non–small cell lung cancers

open access: gold, 2021
Jiefei Han   +18 more
openalex   +1 more source

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