Distorted TCR repertoires define multisystem inflammatory syndrome in children [PDF]
PLOS ONE, 2022 While the majority of children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) display mild or no symptoms, rare individuals develop severe disease presenting with multisystem inflammatory syndrome (MIS-C). The reason for variable clinical manifestations is not understood.
Amna Malik +11 more
openalex +6 more sources
Limited TCR repertoire and ENTPD1 dysregulation mark late-stage COVID-19. [PDF]
iScience, 2021 Summary T cell exhaustion and dysfunction are hallmarks of severe COVID-19. To gain insights into the pathways underlying these alterations, we performed a comprehensive transcriptome analysis of peripheral-blood-mononuclear-cells (PBMCs), spleen, lung ...
Wang N +13 more
europepmc +2 more sources
Exploiting TCR Repertoire Analysis to Select Therapeutic TCRs for Cancer Immunotherapy. [PDF]
CellsOver the past decade, numerous innovative immunotherapy strategies have transformed the treatment of cancer and improved the survival of patients unresponsive to conventional chemotherapy and radiation therapy. Immune checkpoint inhibition approaches aim to block negative regulatory pathways that limit the function of endogenous T cells, while adoptive
Demaël UM +4 more
europepmc +2 more sources
Quantifiable blood TCR repertoire components associate with immune aging. [PDF]
Nat CommunAbstractT cell senescence results in decayed adaptive immune protection in older individuals, with decreased or increased abundance of certain T cell phenotypic subpopulations. However, no study has linked aging to the dynamic changes of T cell clones.
Hu J, Pan M, Reid B, Tworoger S, Li B.
europepmc +4 more sources
Predicting the spectrum of TCR repertoire sharing with a data-driven model of recombination [PDF]
bioRxiv, 2018 Despite the extreme diversity of T cell repertoires, many identical T-cell receptor (TCR) sequences are found in a large number of individual mice and humans.
Callan Jr., Curtis G. +4 more
core +2 more sources
T cell receptor (TCR) repertoire analysis reveals a highly conserved TCR repertoire in a bilateral tumor mouse model [PDF]
bioRxiv, 2021 AbstractTemporal analysis of the T cell receptor (TCR) repertoire has been used to monitor treatment-induced changes in antigen-specific T cells in patients with cancer. However, the lack of experimental models that allow temporal analysis of the TCR repertoire in the same individual in a homogeneous population limits the understanding of the causal ...
Mikiya Tsunoda +5 more
openaire +2 more sources
Rapid identification of CMV-specific TCRs via reverse TCR cloning system based on bulk TCR repertoire data. [PDF]
Front Immunol, 2022 Advances in next-generation sequencing (NGS) have improved the resolution of T-cell receptor (TCR) repertoire analysis, and recent single-cell sequencing has made it possible to obtain information about TCR pairs. In our previous study, cytomegalovirus (CMV) pp65-specific T-cell response restricted by a single human leukocyte antigen (HLA) class I ...
Hong CH, Pyo HS, Baek IC, Kim TG.
europepmc +4 more sources
Identification and characterization of the T cell receptor (TCR) repertoire of the cynomolgus macaque (Macaca Fascicularis) [PDF]
BMC Genomics, 2022 Background Cynomolgus macaque (Macaca fascicularis) is an attractive animal model for the study of human disease and is extensively used in biomedical research.
Swati Jaiswal +14 more
doaj +2 more sources
Frontiers in Immunology, 2018 There is increasing evidence that deep sequencing-based T cell repertoire can sever as a biomarker of immune response in cancer patients; however, the characteristics of T cell repertoire including diversity and similarity, as well as its prognostic ...
Jin-Huan Cui +10 more
doaj +2 more sources
Rapid Evolution of the CD8+ TCR Repertoire in Neonatal Mice [PDF]
The Journal of Immunology, 2016 Abstract Currently, there is little consensus regarding the most appropriate animal model to study acute infection and the virus-specific CD8+ T cell (CTL) responses in neonates. TCRβ high-throughput sequencing in naive CTL of differently aged neonatal mice was performed, which demonstrated differential Vβ family gene usage.
Alison J Carey +9 more
openaire +3 more sources