Results 31 to 40 of about 272,710 (333)

T-Cell Receptor Repertoire as a Predictor of Immune-Related Adverse Events in Renal Cell Carcinoma

Current Issues in Molecular Biology, 2023
Immune checkpoint inhibitors (ICIs) are effective in treating renal cell carcinoma (RCC) but can also cause immune-related adverse events (irAEs). The relationship between irAEs and the T-cell receptor (TCR) repertoire in RCC patients treated with ICIs ...
Takuro Kobayashi, Masayoshi Nagata, Yoshihiro Ikehata, Yuki Nagashima, Naoya Nagaya, Yan Lu, Shigeo Horie   +6 more
doaj   +1 more source

Human γδ TCR Repertoires in Health and Disease [PDF]

Cells, 2020
The T cell receptor (TCR) repertoires of γδ T cells are very different to those of αβ T cells. While the theoretical TCR repertoire diversity of γδ T cells is estimated to exceed the diversity of αβ T cells by far, γδ T cells are still understood as more invariant T cells that only use a limited set of γδ TCRs. Most of our current knowledge of human γδ
Alina Suzann Fichtner, Sarina Ravens, Immo Prinz   +2 more
openaire   +3 more sources

TCR-L: an analysis tool for evaluating the association between the T-cell receptor repertoire and clinical phenotypes

BMC Bioinformatics, 2022
Background T cell receptors (TCRs) play critical roles in adaptive immune responses, and recent advances in genome technology have made it possible to examine the T cell receptor (TCR) repertoire at the individual sequence level.
Meiling Liu, Juna Goo, Yang Liu, Wei Sun, Michael C. Wu, Li Hsu, Qianchuan He   +6 more
doaj   +1 more source

Huge Overlap of Individual TCR Beta Repertoires [PDF]

Frontiers in Immunology, 2013
It has been reported that human TCR repertoires commonly carry so-called public clonotypes – CDR3 variants that are often shared between individuals. Cross-comparison of individual immune repertoires has previously revealed the existence of a population of TCR beta CDR3 variants that are identical at the amino acid level for any two donors (1–3).
Mikhail eShugay, Dmitriy A Bolotin, Ekaterina V Putintseva, Mikhail V Pogorelyy, Ilgar Z Mamedov, Ilgar Z Mamedov, Dmitriy M Chudakov, Dmitriy M Chudakov   +7 more
openaire   +3 more sources

Revealing Clonal Responses of Tumor-Reactive T-Cells Through T Cell Receptor Repertoire Analysis

Frontiers in Immunology, 2022
CD8+ T cells are the key effector cells that contribute to the antitumor immune response. They comprise various T-cell clones with diverse antigen-specific T-cell receptors (TCRs).
Hiroyasu Aoki, Hiroyasu Aoki, Shigeyuki Shichino, Kouji Matsushima, Satoshi Ueha   +4 more
doaj   +1 more source

CD4 Promotes Breadth in the TCR Repertoire [PDF]

The Journal of Immunology, 2001
Abstract A diverse population of MHC class II-restricted CD4 lineage T cells develops in mice that lack expression of the CD4 molecule. In this study, we show that the TCR repertoire selected in the absence of CD4 is distinct, but still overlapping in its properties with that selected in the presence of CD4.
Q, Wang, L, Malherbe, D, Zhang, K, Zingler, N, Glaichenhaus, N, Killeen   +5 more
openaire   +2 more sources

TCR repertoire diversity in Multiple Sclerosis: High-dimensional bioinformatics analysis of sequences from brain, cerebrospinal fluid and peripheral blood

EBioMedicine, 2021
Background T cells play a key role in the pathogenesis of multiple sclerosis (MS), a chronic, inflammatory, demyelinating disease of the central nervous system (CNS).
R. Amoriello, M. Chernigovskaya, V. Greiff, A. Carnasciali, L. Massacesi, A. Barilaro, A. Repice, T. Biagioli, A. Aldinucci, P. Muraro, D. Laplaud, Andreas Lossius, C. Ballerini   +12 more
semanticscholar   +1 more source

Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life

Frontiers in Immunology, 2020
Human cytomegalovirus (CMV) is a highly prevalent herpesvirus, particularly in sub-Saharan Africa, where it is endemic from infancy. The T cell response against CMV is important in keeping the virus in check, with CD8 T cells playing a major role in the ...
Meriem Attaf, Meriem Attaf, Julia Roider, Julia Roider, Julia Roider, Julia Roider, Amna Malik, Cristina Rius Rafael, Cristina Rius Rafael, Garry Dolton, Garry Dolton, Andrew J. Predergast, Andrew J. Predergast, Andrew J. Predergast, Alasdair Leslie, Alasdair Leslie, Thumbi Ndung'u, Thumbi Ndung'u, Thumbi Ndung'u, Thumbi Ndung'u, Thumbi Ndung'u, Henrik N. Kløverpris, Henrik N. Kløverpris, Andrew K. Sewell, Andrew K. Sewell, Philip J. Goulder, Philip J. Goulder   +26 more
doaj   +1 more source

Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance A hyperinflammatory syndrome reminiscent of toxic shock syndrome (TSS) is observed in severe COVID-19 patients, including children with Multisystem Inflammatory Syndrome in Children (MIS-C).
M. H. Cheng, She Zhang, Rebecca A. Porritt, Magali Noval Rivas, L. Paschold, E. Willscher, M. Binder, M. Arditi, I. Bahar   +8 more
semanticscholar   +1 more source

Transient Depletion of CD4+ Cells Induces Remodeling of the TCR Repertoire in Gastrointestinal Cancer

Cancer immunology research, 2021
Analysis of the blood–tumor overlapping TCR repertoire reveals that transient depletion of CD4+ cells causes beneficial remodeling of the TCR repertoire and contributes to the expansion of CD8+ tumor-reactive clones in patients with cancer.
H. Aoki, S. Ueha, Shigeyuki Shichino, H. Ogiwara, K. Shitara, M. Shimomura, Toshihiro Suzuki, T. Nakatsura, M. Yamashita, S. Kitano, S. Kuroda, M. Wakabayashi, M. Kurachi, S. Ito, T. Doi, K. Matsushima   +15 more
semanticscholar   +1 more source