Cancer Communications, 2020 T cells, which are involved in adaptive immunity, are essential in the elimination of tumor cells. Mature T cells can specifically recognize the antigen on the major histocompatibility complex (MHC) molecule through T‐cell receptors (TCR).
Na Li +4 more
doaj +1 more source
Journal of Experimental Medicine, 2021 The thymoproteasome expressed in thymic cortical epithelium optimizes the generation of CD8+ T cells. This study reveals that the thymoproteasome hardwires the TCR repertoire of CD8+ T cells with cortical positive selection independent of thymic negative
I. Ohigashi +12 more
semanticscholar +1 more source
Pathogens, 2020 Enterovirus 71 (EV71) has become an important public health problem in the Asia-Pacific region in the past decades. EV71 infection might cause neurological and psychiatric complications and even death. Although an EV71 vaccine has been currently approved,
Yu-Wen Liao +3 more
doaj +1 more source
Limited T cell receptor repertoire diversity in tuberculosis patients correlates with clinical severity. [PDF]
PLoS ONE, 2012 BACKGROUND: The importance of CD4⁺ and CD8⁺ T cells in protection against tuberculosis (TB) is well known, however, the association between changes to the T cell repertoire and disease presentation has never been analyzed.
Wei Luo +10 more
doaj +1 more source
The T Cell Receptor Repertoire Diversity Following Hematopoietic Stem Cell Transplantation
Iranian Journal of Allergy, Asthma and Immunology, 2022 Immune reconstitution after hematopoietic stem cell transplantation (HSCT) with a conditioning regimen has appeared to be a promising treatment for autoimmune diseases and hematologic malignancies.
Fahimeh Zamani +8 more
doaj +1 more source
DIPG-32. NEOANTIGEN HEAT SHOCK PROTEIN VACCINE, RHSC-DIPGVAX, IS ASSOCIATED WITH INCREASED VACCINE-INDUCED B CELLS AND BCR/TCR REPERTOIRE DIVERSITY IN PEDIATRIC PATIENTS WITH DIFFUSE MIDLINE GLIOMAS [PDF]
Neuro OncolLauren Boland +15 more
europepmc +3 more sources
End stage renal disease patients have a skewed T cell receptor Vβ repertoire [PDF]
, 2015 Background: End stage renal disease (ESRD) is associated with defective T-cell mediated immunity. A diverse T-cell receptor (TCR) Vβ repertoire is central to effective T-cell mediated immune responses to foreign antigens.
Baan, C.C. (Carla) +6 more
core +1 more source
Tracking TCRß sequence clonotype expansions during antiviral therapy using high-throughput sequencing of the hypervariable region [PDF]
, 2016 To maintain a persistent infection viruses such as hepatitis C virus (HCV) employ a range of mechanisms that subvert protective T cell responses. The suppression of antigen-specific T cell responses by HCV hinders efforts to profile T cell responses ...
Arvind H Patel +10 more
core +7 more sources
Characterization of the T cell receptor repertoire causing collagen arthritis in mice [PDF]
, 1993 Collagen type II-induced arthritis (CIA) is generated in susceptible rodent strains by intradermal injections of homologous or heterologous native type II collagen in complete Freund's adjuvant.
Hood, Leroy E. +3 more
core +2 more sources
TCR sequencing and cloning methods for repertoire analysis and isolation of tumor-reactive TCRs [PDF]
Cell Reports Methods, 2023 T cell receptor (TCR) technologies, including repertoire analyses and T cell engineering, are increasingly important in the clinical management of cellular immunity in cancer, transplantation, and other immune diseases. However, sensitive and reliable methods for repertoire analyses and TCR cloning are still lacking.
Raphael Genolet +17 more
openaire +2 more sources