Results 51 to 60 of about 272,710 (333)

Longitudinal analysis reveals age-related changes in the T cell receptor repertoire of human T cell subsets

The Journal of Clinical Investigation, 2022
A diverse T cell receptor (TCR) repertoire is essential for protection against a variety of pathogens, and TCR repertoire size is believed to decline with age.
Xiaoping Sun, Thomas Nguyen, Achouak Achour, Annette Ko, Jeffrey Cifello, Chen Ling, Jay Sharma, Toyoko Hiroi, Yongqing Zhang, Chee W. Chia, William Wood III, Wells W. Wu, Linda Zukley, Je-Nie Phue, Kevin G. Becker, Rong-Fong Shen, Luigi Ferrucci, Nan-ping Weng   +17 more
doaj   +1 more source

Deciphering the TCR Repertoire to Solve the COVID-19 Mystery

TIPS - Trends in Pharmacological Sciences, 2020
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected several millions and killed more than quarter of a million worldwide to date.
Lucas Gutierrez, J. Beckford, Houda Alachkar   +2 more
semanticscholar   +1 more source

Time-spatial analysis of T cell receptor repertoire in esophageal squamous cell carcinoma patients treated with combined radiotherapy and PD-1 blockade

OncoImmunology, 2022
T cell receptor (TCR) repertoire as a biomarker for predicting immunotherapy efficiency has been widely studied. However, its dynamics during radiotherapy combined with PD-1 blockade is little known. Using paired tumor and blood samples from the phase Ib
Cihui Yan, Xiaoxue Ma, Zhoubo Guo, Xiaoying Wei, Dong Han, Tian Zhang, Xi Chen, Fuliang Cao, Jie Dong, Gang Zhao, Xuan Gao, Tao Wang, Yao Jiang, Ping Wang, Qingsong Pang, Wencheng Zhang   +15 more
doaj   +1 more source

Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness. [PDF]

, 2017
Zap70 plays a critical role in normal T cell development and T cell function. However, little is known about how perturbation of allosteric autoinhibitory mechanisms in Zap70 impacts T cell biology.
Chen, Yiling, Cheng, Debra A, Hsu, Lih-Yun, Liang, Hong-Erh, Weiss, Arthur   +4 more
core   +2 more sources

Tumor-infiltrating human CD4+ regulatory T cells display a distinct TCR repertoire and exhibit tumor and neoantigen reactivity

Science immunology, 2019
Intratumoral Treg cells are tumor/neoantigen reactive. Neoantigen reactivity Elevated frequencies of intratumoral CD4+ regulatory T (Treg) cells have typically been associated with more rapid tumor progression, but the antigen specificity of these Treg ...
M. Ahmadzadeh, A. Pasetto, Li Jia, D. Deniger, S. Stevanović, P. Robbins, S. Rosenberg   +6 more
semanticscholar   +1 more source

Antigen receptor variable region repertoires expressed by T cells infiltrating thyroid, retroorbital, and pretibial tissue in Graves' disease [PDF]

, 1996
To date, it has remained unclear whether T cells infiltrating thyroid, retroorbital, and pretibial tissue of patients with Graves' ophthalmopathy and pretibial dermopathy represent a primary immune response that is directed against certain antigenic ...
Heufelder, Armin E., Scriba, Peter C., Wenzel, Björn E.   +2 more
core   +1 more source

Characteristics of TCR Repertoire Associated With Successful Immune Checkpoint Therapy Responses

Frontiers in Immunology, 2020
Immunotherapies have revolutionized cancer treatment. In particular, immune checkpoint therapy (ICT) leads to durable responses in some patients with some cancers. However, the majority of treated patients do not respond.
Joel Kidman, Nicola Principe, M. Watson, T. Lassmann, R. Holt, A. Nowak, W. Lesterhuis, R. Lake, Jonathan Chee   +8 more
semanticscholar   +1 more source

The splenic T cell receptor repertoire during an immune response against a complex antigen: Expanding private clones accumulate in the high and low copy number region.

PLoS ONE, 2022
Large cellular antigens comprise a variety of different epitopes leading to a T cell response of extreme diversity. Therefore, tracking such a response by next generation sequencing of the T cell receptor (TCR) in order to identify common TCR properties ...
Martin Meinhardt, Cornelia Tune, Lisa-Kristin Schierloh, Andrea Schampel, René Pagel, Jürgen Westermann   +5 more
doaj   +1 more source

Immunosenescence and Autoimmunity: Exploiting the T-Cell Receptor Repertoire to Investigate the Impact of Aging on Multiple Sclerosis

Frontiers in Immunology, 2021
T-cell receptor (TCR) repertoire diversity is a determining factor for the immune system capability in fighting infections and preventing autoimmunity.
Roberta Amoriello, Alice Mariottini, Clara Ballerini   +2 more
doaj   +1 more source

A Long-Playing CD about the γδ TCR Repertoire [PDF]

Immunity, 2013
In this issue of Immunity, a study by Luoma et al. (2013) provides structural evidence for direct interactions of human Vδ1(+) T cell receptors with CD1d, capping a long trail of evidence that CD1 might be a major influence on γδ T cell biology.
Hayday, Adrian, Vantourout, Pierre
openaire   +3 more sources