Results 61 to 70 of about 272,710 (333)

TCR Repertoire Diversity of Peripheral PD-1+CD8+ T Cells Predicts Clinical Outcomes after Immunotherapy in Patients with Non–Small Cell Lung Cancer

Cancer immunology research, 2019
Noninvasive predictors of responses to immune checkpoint blockade are needed. Greater T-cell receptor repertoire diversity of peripheral blood PD-1+CD8+ T cells is associated with better survival after anti–PD-1/PD-L1 therapy in the context of non–small ...
Jiefei Han, J. Duan, H. Bai, Yuqi Wang, R. Wan, Xin Wang, Si Chen, Yanhua Tian, Di Wang, K. Fei, Zhuoran Yao, Shuhang Wang, Zhimin Lu, Zhijie Wang, Jie Wang   +14 more
semanticscholar   +1 more source

Comprehensive analysis of TCR repertoire in COVID-19 using single cell sequencing

Genomics, 2020
T-cell receptor (TCR) is crucial in T cell-mediated virus clearance. To date, TCR bias has been observed in various diseases. However, studies on the TCR repertoire of COVID-19 patients are lacking.
Pingping Wang, Xiyun Jin, Wenyang Zhou, Meng Luo, Zhaochun Xu, Chang Xu, Yiqun Li, Kexin Ma, Huimin Cao, Y. Huang, G. Xue, Shuilin Jin, Huan Nie, Qinghua Jiang   +13 more
semanticscholar   +1 more source

Characterization of human T cell receptor repertoire data in eight thymus samples and four related blood samples

Data in Brief, 2021
T cell receptor (TCR) is a heterodimer consisting of TCRα and TCRβ chains that are generated by somatic recombination of multiple gene segments. Nascent TCR repertoire undergoes thymic selections where non-functional and potentially autoreactive ...
Nelli Heikkilä, Iivari Kleino, Reetta Vanhanen, Dawit A. Yohannes, Ilkka P. Mattila, Jari Saramäki, T. Petteri Arstila   +6 more
doaj   +1 more source

Controversies concerning thymus-derived regulatory T cells: fundamental issues and a new perspective [PDF]

, 2015
Thymus-derived regulatory T cells (Tregs) are considered to be a distinct T-cell lineage that is genetically programmed and specialised for immunosuppression.
Ono, M, Tanaka, RJ
core   +1 more source

System-wide Analysis of the T Cell Response

Cell Reports, 2016
The T cell receptor (TCR) controls the cellular adaptive immune response to antigens, but our understanding of TCR repertoire diversity and response to challenge is still incomplete.
Ruxandra Covacu, Hagit Philip, Merja Jaronen, Jorge Almeida, Jessica E. Kenison, Samuel Darko, Chun-Cheih Chao, Gur Yaari, Yoram Louzoun, Liran Carmel, Daniel C. Douek, Sol Efroni, Francisco J. Quintana   +12 more
doaj   +1 more source

A Nextflow pipeline for T-cell receptor repertoire reconstruction and analysis from RNA sequencing data

ImmunoInformatics, 2022
T-cell receptor (TCR) analysis is relevant for the study of immune system diseases. The expression of TCRs is usually measured with targeted sequencing approaches where TCR genes are selectively amplified.
Teresa Rubio, Maria Chernigovskaya, Susanna Marquez, Cristina Marti, Paula Izquierdo-Altarejos, Amparo Urios, Carmina Montoliu, Vicente Felipo, Ana Conesa, Victor Greiff, Sonia Tarazona   +10 more
doaj   +1 more source

Autoencoder based local T cell repertoire density can be used to classify samples and T cell receptors.

PLoS Computational Biology, 2021
Recent advances in T cell repertoire (TCR) sequencing allow for the characterization of repertoire properties, as well as the frequency and sharing of specific TCR. However, there is no efficient measure for the local density of a given TCR.
Shirit Dvorkin, Reut Levi, Yoram Louzoun
doaj   +1 more source

Individual Epitope-Specific CD8⁺ T Cell Immune Responses Are Shaped Differently during Chronic Viral Infection

Pathogens, 2023
A hallmark in chronic viral infections are exhausted antigen-specific CD8+ T cell responses and the inability of the immune system to eliminate the virus.
Sebastian Klein, Jasmin Mischke, Finn Beruldsen, Immo Prinz, Dinler A. Antunes, Markus Cornberg, Anke R. M. Kraft   +6 more
doaj   +1 more source

Positive selection of V beta 8+ CD4-8- thymocytes by class I molecules expressed by hematopoietic cells. [PDF]

, 1993
A small subset of T cells of mature phenotype express the alpha/beta T cell receptor, but not CD4 and CD8 coreceptors (alpha/beta double-negative [DN] cells).
Bix, M, Coles, M, RAULET, David H.
core   +1 more source

A novel signature for stratifying the molecular heterogeneity of the tissue-infiltrating T-cell receptor repertoire reflects gastric cancer prognosis

Scientific Reports, 2017
Many basic properties of the T-cell receptor (TCR) repertoire require clarification, and the changes occurring in the TCR repertoire during carcinogenesis, especially during precancerous stages, remain unclear. This study used deep sequencing analyses to
Manchao Kuang, Jieyao Cheng, Chengli Zhang, Lin Feng, Xue Xu, Yajing Zhang, Ming Zu, Jianfang Cui, Hang Yu, Kaitai Zhang, Aiming Yang, Shujun Cheng   +11 more
doaj   +1 more source