Results 91 to 100 of about 283,612 (294)

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

open access: yesFEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde   +3 more
wiley   +1 more source

PRIME: A System for Multi-lingual Patent Retrieval

open access: yes, 2001
Given the growing number of patents filed in multiple countries, users are interested in retrieving patents across languages. We propose a multi-lingual patent retrieval system, which translates a user query into the target language, searches a ...
Fujii, Atsushi   +3 more
core   +2 more sources

Disaster risk management or adaptation to climate change; How to deal with climate issue in Colombia? Analysis from agenda setting and traveling model perspectives of the elaboration of climate policies. [PDF]

open access: yes, 2019
The main purpose of this work is to understand, in an actor oriented perspective, the context in which climate policy are formulated in a country, Colombia.
Howland, Fanny, Le Coq, Jean-François
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

On some persuasive strategies in technical discourse: Cross-cultural analysis of directives in English and Czech technical manuals

open access: yesTopics in Linguistics, 2018
The aim of the paper is to provide a cross-cultural analysis of selected linguistic realizations of persuasion in the language of technical communication represented by the genre of technical manuals (TM) and to identify the differences and similarities ...
Povolná Renata
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

An Offline Corpus for Legal Translations into Italian: a Case Study with a Land Lease Agreement

open access: yesAltre Modernità, 2020
Offline corpora are claimed to be helpful in technical translations. This paper explores whether a corpus of Italian land lease agreement samples and the civil code can be supportive in legal translations.
Patrizia Giampieri
doaj  

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Deep tissue photoacoustic imaging with light and sound

open access: yesnpj Imaging
Photoacoustic computed tomography (PACT) can harvest diffusive photons to image the optical absorption contrast of molecules in a scattering medium, with ultrasonically-defined spatial resolution.
Luca Menozzi, Junjie Yao
doaj   +1 more source

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