Results 71 to 80 of about 27,096 (257)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

On some persuasive strategies in technical discourse: Cross-cultural analysis of directives in English and Czech technical manuals

open access: yesTopics in Linguistics, 2018
The aim of the paper is to provide a cross-cultural analysis of selected linguistic realizations of persuasion in the language of technical communication represented by the genre of technical manuals (TM) and to identify the differences and similarities ...
Povolná Renata
doaj   +1 more source

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

An Offline Corpus for Legal Translations into Italian: a Case Study with a Land Lease Agreement

open access: yesAltre Modernità, 2020
Offline corpora are claimed to be helpful in technical translations. This paper explores whether a corpus of Italian land lease agreement samples and the civil code can be supportive in legal translations.
Patrizia Giampieri
doaj  

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

Deep tissue photoacoustic imaging with light and sound

open access: yesnpj Imaging
Photoacoustic computed tomography (PACT) can harvest diffusive photons to image the optical absorption contrast of molecules in a scattering medium, with ultrasonically-defined spatial resolution.
Luca Menozzi, Junjie Yao
doaj   +1 more source

Review of the Quran translation from shah waliullah Dehlavi [PDF]

open access: yesپژوهش‌های ترجمه در زبان و ادبیات عربی, 2014
The Holy Quran, The eternal miracle of Godandthe only outstanding book of universe has longbeenat the center ofthoughtand attention of scientists of Muslims and non-Muslim.
Ebrahim Fallah
doaj  

MACHINE TRANSLATION SYSTEMS: QUALITY AND POSSIBLE WAYS OF USE

open access: yesВестник Волгоградского государственного университета: Серия 2. Языкознание, 2014
The article considers two machine translation systems, PROMT and Google Translate, which work on different principles. PROMT works on the so-called "translation by the rules" principle.
Novozhilova Anna Alekseevna
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

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