Results 71 to 80 of about 3,863,250 (295)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Machine Translation of Independent Nominal Phrases in Technical Texts

open access: yesELOPE
This paper deals with machine translations of independent noun phrases in technical texts, which are not part of any sentence structure but function on their own, typically in tables and illustrations.
Simon Zupan   +2 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

GENDER BIAS IN ENGLISH-TO-UKRAINIAN MACHINE TRANSLATION: A CORPUS-BASED STUDY

open access: yesІноземна філологія
This study investigates gender bias in English-to-Ukrainian machine translation by analyzing translations generated by Google Translate and DeepL. The analysis examines how these systems handle genderneutral source texts, particularly in professional ...
Yuliia Naniak
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Gendering neutrality: a cultural-communicative analysis of translating English imperatives into Arabic

open access: yesFrontiers in Communication
IntroductionThis study investigates how gender is encoded when grammatically gender-neutral English imperative clauses are translated into Arabic. Focusing on instructional discourse, this article examines whether gender assignment in translation is ...
Niveen Mohammad Zayed   +5 more
doaj   +1 more source

Towards a participatory approach to Bible translation (PABT)

open access: yesActa Theologica, 2009
It is generally acknowledged that the participation of the receptor community may enhance the community’s ownership and acceptability of the translation.
D. C. Chemorion
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

A Hybrid Transformer-Based System for Multilingual Translation with Domain-Specific Terminology Explanation

open access: yesTeknika
Communication across languages becomes particularly challenging when specialized terminology is involved because literal translations often fail to convey the precise meanings essential in professional contexts. Current translation systems have problems
Oyebamiji Micheal Tomiwa
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

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