Results 81 to 90 of about 2,733 (199)
Dynamic Cap‐Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease
Advanced Science, Volume 12, Issue 26, July 10, 2025.The first crystal structure of MPXV I7L protease, revealing its unique dimeric form is resolved. The structures and MD simulations uncovered a dynamic cap region that regulates substrate access to the active site. The structural basis of substrate recognition and the catalytic mechanism are elucidated, which led to the development of a FRET‐based assay
Haixia Su +12 more
wiley +1 more source
The Human Mpox Global Outbreak: Available Control Tools and the Opportunity to Break a Cycle of Neglect in Endemic Countries [PDF]
, 2023 The 2022 global outbreak of human Mpox (formerly monkeypox) virus (MPXV) infection outside of the usual endemic zones in Africa challenged our understanding of the virus’s natural history, transmission dynamics, and risk factors.
Andrei, G +16 more
core
Journal of Medical Virology, Volume 97, Issue 7, July 2025.ABSTRACT In August 2024, the World Health Organization declared mpox infection a Public Health Emergency of International Concern for second time since 2022 and recommended vaccinating all people at‐risk, such as people with HIV‐1 (PWH) and prophylaxis pre‐exposition (PrEP) users.
Olivia de la Calle‐Jiménez +16 more
wiley +1 more source
Small Structures, Volume 6, Issue 7, July 2025.This illustration depicts a comprehensive strategy against monkeypox, showcasing its transmission, symptoms, and prevention. Centralized around nanomaterials and biosensors, it integrates early screening, Internet of Things, vaccination, and community involvement through collaboration among healthcare workers, scientists, researchers, social groups ...
Vishal Chaudhary +3 more
wiley +1 more source
Tecovirimat in the management of poxviruses: a narrative review of available evidence
The Egyptian Journal of Internal MedicineIntroduction Tecovirimat (TPOXX) is an effective antiviral medication recommended for treating smallpox and other Orthopoxvirus infections. With the rise in monkeypox (mpox) cases globally, there is an urgent need to explore therapeutic options to manage
Olalekan John Okesanya +13 more
doaj +1 more source
Interim guidance for prevention and treatment of monkeypox in persons with HIV infection \u2014 United States, August 2022 [PDF]
What is already known about this topic? A multinational monkeypox outbreak disproportionately affecting men who have sex with men, including persons with HIV infection, is ongoing worldwide.What is added by this report?
core
Clinical considerations for mpox in people who are pregnant or breastfeeding [PDF]
Updated March 27, 2023Mpox and Pregnancy -- Signs and Symptoms -- Treatment -- Vaccines -- Contact and Breastfeeding -- Infection ...
core
Challenges in clinical diagnosis of Clade I Mpox: Highlighting the need for enhanced diagnostic approaches [PDF]
Background: Due to limited diagnostic capacity and availability of point-of-care tests, diagnosis of Clade I mpox in the geographical regions most affected is usually on clinical grounds.
Boum, Yap +8 more
core +2 more sources