Results 71 to 80 of about 1,939 (155)

Drug Repurposing for Monkeypox: An Alternative Strategy for Emergency Response

JPSCR: Journal of Pharmaceutical Science and Clinical Research
The global monkeypox (MPOX) outbreak, which has resulted in more than 100,000 confirmed cases across over 120 countries, underscores the urgent need for effective therapeutic strategies. MPOX, caused by a virus belonging to the Orthopoxvirus genus, poses
Luthfi Harbulcholizi, Jekmal Malau, Ihsan Alfiandri, Iqbal Zulkifli, Ratika Rahmasari   +4 more
doaj   +1 more source

Expanded Access Programme for the use of tecovirimat for the treatment of monkeypox infection: A study protocol for an Expanded Access Programme.

PLoS ONE
BackgroundMonkeypox is a viral zoonotic disease commonly reported in humans in parts of Central and West Africa. This protocol is for an Expanded Access Programme (EAP) to be implemented in the Central African Republic, where Clade I monkeypox virus ...
Josephine Bourner, Festus Devincy Redji Mbrenga, Christian Noël Malaka, Jake Dunning, Amanda Rojek, Emmanuel Fandema, Peter Horby, Yap Boum, Emmanuel Nakouné, Piero Olliaro   +9 more
doaj   +1 more source

Tecovirimat [PDF]

, 2020
openaire   +1 more source

“If that would have lessened my symptoms, that would have been great...”: a qualitative study about the acceptability of tecovirimat as treatment for mpox

BMC Medicine
Background Tecovirimat, an antiviral treatment for smallpox, was approved as a treatment for mpox by the European Medicines Agency in January 2022.
Sara Paparini, Rosalie Hayes, Benjamin Weil, Will Nutland, Ismael Maatouk, Teodora Wi, Chloe M. Orkin, Rosamund Lewis   +7 more
doaj   +1 more source

Mechanisms of Tecovirimat Antiviral Activity and Poxvirus Resistance

Abstract Mpox is a zoonotic disease endemic in central and west Africa. However, since 2022, human-adapted mpox virus (MPXV) strains are causing large outbreaks spreading outside these regions, leading the World Health Organization to declare public health emergency twice. Tecovirimat, the most widely used drug to treat these infections, blocks
Vernuccio, Riccardo, Martínez León, Alejandro, Poojari, Chetan, Buchrieser, Julian, Selverian, Christopher, Jaleta, Yakin, Meola, Annalisa, Guivel-Benhassine, Florence, Porrot, Françoise, Haouz, Ahmed, Chevreuil, Maelen, Raynal, Bertrand, Mercer, Jason, Simon-Loriere, Etienne, Chandran, Karti, Schwartz, Olivier, Hub, Jochen S., Guardado-Calvo, Pablo   +17 more
openaire   +4 more sources

Treatment of Severe Ocular Mpox with Cidofovir and Tecovirimat. [PDF]

Emerg Infect Dis
Brousse X, Kreidie R, Mourgues E, Fraysse L, Lahouati M, Servant V, Burrel S, Saunier V, Cazanave C.   +8 more
europepmc   +1 more source

Variole simienne chez un homme de 49 ans possiblement atteint d’un syndrome inflammatoire de reconstitution immunitaire. [PDF]

CMAJ
Goto T, Maruno M, Sakamoto N.
europepmc   +1 more source

Monkeypox Virus Shedding Despite Tecovirimat Treatment in a Cohort in Toronto, Canada. [PDF]

J Infect Dis
Hurst JR, Addo M, Li A, Khera SS, Persaud R, Bertucci C, Hummel M, Espinosa OJP, Chan AK, Walmsley S, Mishra S, Tan DHS, Kozak R.   +12 more
europepmc   +1 more source

Safety and efficacy of major antiviral and immune therapies in pregnancy for maternal viral infections: evidence synthesis of maternal and neonatal outcomes. [PDF]

Front Med (Lausanne)
Sleman S, Abid OI, Abdullah BJ, Abass ZA, Ameen MB.   +4 more
europepmc   +1 more source

Mpox in a 49-year-old man with possible immune reconstitution inflammatory syndrome. [PDF]

CMAJ
Goto T, Maruno M, Sakamoto N.
europepmc   +1 more source