Results 41 to 50 of about 1,717 (156)

Development of Bisphosphonate-Conjugated Antibiotics to Overcome Pharmacodynamic Limitations of Local Therapy: Initial Results with Carbamate Linked Sitafloxacin and Tedizolid

Antibiotics, 2021
The use of local antibiotics to treat bone infections has been questioned due to a lack of clinical efficacy and emerging information about Staphylococcus aureus colonization of the osteocyte-lacuno canalicular network (OLCN).
Emmanuela Adjei-Sowah, Yue Peng, Jason Weeks, Jennifer H. Jonason, Karen L. de Mesy Bentley, Elysia Masters, Yugo Morita, Gowrishankar Muthukrishnan, Philip Cherian, X. Eric Hu, Charles E. McKenna, Frank H. Ebetino, Shuting Sun, Edward M. Schwarz, Chao Xie   +14 more
doaj   +1 more source

Pulmonary Disposition of Tedizolid following Administration of Once-Daily Oral 200-Milligram Tedizolid Phosphate in Healthy Adult Volunteers [PDF]

Antimicrobial Agents and Chemotherapy, 2012
ABSTRACT This study assessed the pulmonary disposition of tedizolid, an oxazolidinone, in adult volunteers receiving 200 mg of the prodrug tedizolid phosphate orally every 24 h for 3 days to steady state. Plasma samples were collected over the dosing interval, and participants were randomized to undergo bronchoalveolar lavage ...
Seth T, Housman, J Samuel, Pope, John, Russomanno, Edward, Salerno, Eric, Shore, Joseph L, Kuti, David P, Nicolau   +6 more
openaire   +2 more sources

Facile Synthesis of Oxazolidinones as Potential Antibacterial Agents

ChemistryOpen, Volume 14, Issue 7, July 2025.
A microwave‐assisted method synthesizes novel oxazolidinone analogues via a proline‐initiated three‐component Mannich reaction and subsequent cyclization. The resulting analogues show antibacterial activity against M. smegmatis, with a minimum MIC of 8 mg/L, which is comparable to Rifampicin.
Secret P. Els, Kimberleigh B. Govender, Mxolisi K. Sokhela, Nilay Bhatt, Nakita Reddy, Hendrik G. Kruger, Per I. Arvidsson, Hendra Gunosewoyo, Thavendran Govender, Tricia Naicker   +9 more
wiley   +1 more source

Pharmacokinetic/pharmacodynamic analysis of tedizolid phosphate against Staphylococcus aureus and Streptococcus pneumoniae in children, adolescents, and adults by Monte Carlo simulation

Journal of Global Antimicrobial Resistance
Objective: The objective of this study was to investigate the cumulative fraction of response of various dosage regimens of tedizolid phosphate against Staphylococcus aureus and Streptococcus pneumoniae in children, adolescents, and adults.
Xiao-Chen Wei, Ming-Feng Zhao, Hai-Rong Lv, Xia Xiao   +3 more
doaj   +1 more source

Quantification of Oseltamivir Phosphate Enantiomeric Impurity by Chiral HPLC Method With the Aid of Solvent Extraction and Phosphate Salt‐Out Method

Chirality, Volume 37, Issue 5, May 2025.
In this method, oseltamivir phosphate enantiomeric impurity is quantified through the chiral HPLC method by removal of phosphate salt through solvent extraction coupled with the salt‐out method. Chiral HPLC confirms the presence of drugs and impurities in the organic layer.
Torati Srinivas, K. V. N. Suresh Reddy, Challa Madhavi, M. Kiranmai Reddy   +3 more
wiley   +1 more source

Dual-Drug Delivery via Zein In Situ Forming Implants Augmented with Titanium-Doped Bioactive Glass for Bone Regeneration: Preparation, In Vitro Characterization, and In Vivo Evaluation

Pharmaceutics, 2022
In situ forming implants (IFIs) are non-surgical approach using biodegradable polymers to treat bone fractures. The study aimed at preparing dual-drug-loaded IFIs to deliver pitavastatin (osteogenic drug) and tedizolid (antibiotic) using zein as the ...
Alaa Emad Eldeeb, Salwa Salah, Mostafa Mabrouk, Mohammed S. Amer, Nermeen A. Elkasabgy   +4 more
doaj   +1 more source

A review of antibiotic safety in pregnancy—2025 update

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 45, Issue 4, Page 227-237, April 2025.
Abstract Antibiotics constitute the majority of prescriptions for women during pregnancy. Common bacterial infections, including urinary tract infections, skin and soft tissue infections, and upper and lower respiratory tract infections, are expected in pregnancy, similar to the general public.
Johny Nguyen, Victoria Madonia, Christopher M. Bland, Kayla R. Stover, Lea S. Eiland, Julia Keating, Madeline Lemmon, P. Brandon Bookstaver, as part of the Southeastern Research Group Endeavor (SERGE‐45) research network   +8 more
wiley   +1 more source

New developments in the management of severe skin and deep skin structure infections – focus on tedizolid

Therapeutics and Clinical Risk Management, 2015
Michael J Durkin,1 G Ralph Corey2,3 1Department of Medicine, Division of Infectious Diseases, Duke University, Durham, NC, USA; 2Department of Medicine, Duke Clinical Research Institute, Durham, NC, USA; 3Duke Global Health Institute, Durham ...
Durkin MJ, Corey GR
doaj  

New Antimicrobials for Gram-Positive Sustained Infections: A Comprehensive Guide for Clinicians

Pharmaceuticals, 2023
Antibiotic resistance is a public health problem with increasingly alarming data being reported. Gram-positive bacteria are among the protagonists of severe nosocomial and community infections.
Davide Carcione, Jari Intra, Lilia Andriani, Floriana Campanile, Floriana Gona, Silvia Carletti, Nicasio Mancini, Gioconda Brigante, Dario Cattaneo, Sara Baldelli, Mattia Chisari, Alessandra Piccirilli, Stefano Di Bella, Luigi Principe   +13 more
doaj   +1 more source

Complicated and deep bacterial skin and soft tissue infections

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 23, Issue 3, Page 357-375, March 2025.
Summary Complicated erysipelas, cellulitis, and necrotizing soft tissue infections belong to the spectrum of bacterial infections affecting the skin and underlying soft tissues. Their frequency as well as risk of recurrence and complicated disease course pose a significant health burden.
Christine Prodinger, Arno Lechner, Arno Hintersteininger, Jan Marco Kern, Matthias Meißnitzer, Damian Meyersburg, Johann W. Bauer, Martin Laimer   +7 more
wiley   +1 more source