Results 61 to 70 of about 2,247 (204)

Pharmacokinetics of Tedizolid in Adults with Cystic Fibrosis [PDF]

Open Forum Infectious Diseases, 2017
Abstract Background The presence of MRSA in the airways of patients with CF is associated with more rapid lung function decline and a higher mortality. Tedizolid (TDZ) is an oxazolidinone antibiotic with potent activity against MRSA; however, the pharmacokinetics (PK) in CF have not been described ...
Joshua Wang, Jenny Park, Jordanna Jayne, Timothy Bensman, David D’Argenio, Lynn Fukushima, Adupa Rao, Paul Beringer   +7 more
openaire   +1 more source

Facile Synthesis of Oxazolidinones as Potential Antibacterial Agents

ChemistryOpen, Volume 14, Issue 7, July 2025.
A microwave‐assisted method synthesizes novel oxazolidinone analogues via a proline‐initiated three‐component Mannich reaction and subsequent cyclization. The resulting analogues show antibacterial activity against M. smegmatis, with a minimum MIC of 8 mg/L, which is comparable to Rifampicin.
Secret P. Els, Kimberleigh B. Govender, Mxolisi K. Sokhela, Nilay Bhatt, Nakita Reddy, Hendrik G. Kruger, Per I. Arvidsson, Hendra Gunosewoyo, Thavendran Govender, Tricia Naicker   +9 more
wiley   +1 more source

Quantification of Oseltamivir Phosphate Enantiomeric Impurity by Chiral HPLC Method With the Aid of Solvent Extraction and Phosphate Salt‐Out Method

Chirality, Volume 37, Issue 5, May 2025.
In this method, oseltamivir phosphate enantiomeric impurity is quantified through the chiral HPLC method by removal of phosphate salt through solvent extraction coupled with the salt‐out method. Chiral HPLC confirms the presence of drugs and impurities in the organic layer.
Torati Srinivas, K. V. N. Suresh Reddy, Challa Madhavi, M. Kiranmai Reddy   +3 more
wiley   +1 more source

Determination of Tedizolid in Bacterial Growth Medium Mueller-Hinton Broth by High-Performance Liquid Chromatography and Its Application to an In Vitro Study in the Hollow-Fiber Infection Model

Separations, 2021
Pharmacokinetic/pharmacodynamic (PKPD) studies of anti-infectives are frequently performed in in vitro infection models where accurate quantification of antibiotic concentrations in bacterial growth media is crucial to establish PK/PD relationships. Here,
Khalid Iqbal, Aliki Milioudi, Elena Haro Martínez, Sebastian Georg Wicha   +3 more
doaj   +1 more source

A review of antibiotic safety in pregnancy—2025 update

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 45, Issue 4, Page 227-237, April 2025.
Abstract Antibiotics constitute the majority of prescriptions for women during pregnancy. Common bacterial infections, including urinary tract infections, skin and soft tissue infections, and upper and lower respiratory tract infections, are expected in pregnancy, similar to the general public.
Johny Nguyen, Victoria Madonia, Christopher M. Bland, Kayla R. Stover, Lea S. Eiland, Julia Keating, Madeline Lemmon, P. Brandon Bookstaver, as part of the Southeastern Research Group Endeavor (SERGE‐45) research network   +8 more
wiley   +1 more source

In Vitro Susceptibility Testing of Tedizolid against Nontuberculous Mycobacteria

, 2017
Tedizolid is a new oxazolidinone with improved in vitro and intracellular potency against Mycobacterium tuberculosis , including multidrug-resistant strains, and some species of nontuberculous mycobacteria (
Richard J. Wallace, Barbara A. Brown-Elliott   +1 more
core   +1 more source

Complicated and deep bacterial skin and soft tissue infections

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 23, Issue 3, Page 357-375, March 2025.
Summary Complicated erysipelas, cellulitis, and necrotizing soft tissue infections belong to the spectrum of bacterial infections affecting the skin and underlying soft tissues. Their frequency as well as risk of recurrence and complicated disease course pose a significant health burden.
Christine Prodinger, Arno Lechner, Arno Hintersteininger, Jan Marco Kern, Matthias Meißnitzer, Damian Meyersburg, Johann W. Bauer, Martin Laimer   +7 more
wiley   +1 more source

Komplizierte und tiefe bakterielle Haut‐ und Weichteilinfektionen

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 23, Issue 3, Page 357-376, March 2025.
Zusammenfassung Komplizierte Erysipele, Phlegmone und nekrotisierende Weichteilinfektionen sind bakterielle Haut‐ und Weichteilinfektionen (BHWI), die aufgrund ihrer Häufigkeit, der Neigung zu Rezidiven und dem Auftreten komplizierter Verläufe ein bedeutendes Gesundheitsproblem darstellen.
Christine Prodinger, Arno Lechner, Arno Hintersteininger, Jan Marco Kern, Matthias Meißnitzer, Damian Meyersburg, Johann W. Bauer, Martin Laimer   +7 more
wiley   +1 more source

Tolerance of Prolonged Oral Tedizolid for Prosthetic Joint Infections: Results of a Multicentre Prospective Study

Antibiotics, 2020
Objectives: Data on clinical and biological tolerance of tedizolid (TZD) prolonged therapy are lacking. Methods: We conducted a prospective multicentre study including patients with prosthetic joint infections (PJIs) who were treated for at least 6 weeks
Eric Senneville, Aurélien Dinh, Tristan Ferry, Eric Beltrand, Nicolas Blondiaux, Olivier Robineau   +5 more
doaj   +1 more source

Managing the Complex Intersection Between Substance Use Disorders and Infectious Diseases

JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, Volume 9, Issue 3, March 2026.
Karissa Chow, Amanda Binkley, Jessica Meisner, Samantha Huo, Matthew Hinton   +4 more
wiley   +1 more source