Results 41 to 50 of about 2,247 (204)

Retrospective Real-World Evaluation of Outcomes in Patients with Skin and Soft Structure Infections Treated with Tedizolid in an Outpatient Setting

Infectious Diseases and Therapy, 2020
Introduction Outcomes data for patients who received tedizolid for acute bacterial skin and skin-structure infections (ABSSSIs) are scant. We provide a real-world analysis of economic and clinical outcomes following tedizolid use in the outpatient ...
Ravina Kullar, Laura A. Puzniak, Jason P. Swindle, Thomas Lodise   +3 more
doaj   +1 more source

Actividad in vitro del tedizolid y de antibióticos de comparación en aislamientos de Staphylococcus aureus resistentes a meticilina en infecciones de piel y tejidos blandos en siete hospitales de Colombia

Biomédica: revista del Instituto Nacional de Salud, 2018
Introducción. Staphylococcus aureus resistente a meticilina (SARM) causa infecciones graves de la piel y los tejidos blandos en los hospitales y, en los últimos años, en la comunidad.
Aura Lucía Leal, María Victoria Ovalle, Jorge Alberto Cortés, Anita María Montañes, Zandra Rocío de la Rosa, José Yesid Rodríguez, Sandra Gualtero, Beatriz Ariza, Otto Sussman, María del Pilar Torres   +9 more
doaj   +1 more source

In vitro susceptibility of methicillin-resistant Staphylococcus aureus isolates from skin and soft tissue infections to vancomycin, daptomycin, linezolid and tedizolid

Brazilian Journal of Infectious Diseases, 2017
Introduction: Treatment of multidrug-resistant Gram-positive infections caused by Staphylococcus aureus remains as a clinical challenge due to emergence of new resistance mechanisms.
Johanna Marcela Vanegas Múnera, Ana María Ocampo Ríos, Daniela Montoya Urrego, Judy Natalia Jiménez Quiceno   +3 more
doaj   +1 more source

The Sterilizing Effect of Intermittent Tedizolid for Pulmonary Tuberculosis [PDF]

Clinical Infectious Diseases, 2018
Linezolid exhibits remarkable sterilizing effect in tuberculosis; however, a large proportion of patients develop serious adverse events. The congener tedizolid could have a better side-effect profile, but its sterilizing effect potential is unknown.We performed a 42-day tedizolid exposure-effect and dose-fractionation study in the hollow fiber system ...
Shashikant Srivastava, Devyani Deshpande, Eric Nuermberger, Pooi S Lee, Kayle Cirrincione, Keertan Dheda, Tawanda Gumbo   +6 more
openaire   +2 more sources

Nonclinical and pharmacokinetic assessments to evaluate the potential of tedizolid and linezolid to affect mitochondrial function [PDF]

, 2015
Prolonged treatment with the oxazolidinone linezolid is associated with myelosuppression, lactic acidosis, and neuropathies, toxicities likely caused by impairment of mitochondrial protein synthesis (MPS).
Radovsky, Ann, Prokocimer, Philippe, Flanagan, Shawn, Das, Debaditya, Fiedler-Kelly, Jill, McKee, Edward E, Passarell, Julie, Tulkens, Paul M., Hosako, Hiromi   +8 more
core   +1 more source

Pharmacokinetics of Tedizolid in Subjects with Renal or Hepatic Impairment [PDF]

Antimicrobial Agents and Chemotherapy, 2014
ABSTRACT Two open-label, single-dose, parallel-group studies were conducted to characterize the pharmacokinetics of the novel antibacterial tedizolid and the safety of tedizolid phosphate, its prodrug, in renally or hepatically impaired subjects.
S, Flanagan, S L, Minassian, D, Morris, R, Ponnuraj, T C, Marbury, H W, Alcorn, E, Fang, P, Prokocimer   +7 more
openaire   +2 more sources

Perspectives of Positively Charged Nanocrystals of Tedizolid Phosphate as a Topical Ocular Application in Rabbits

Molecules, 2022
The aim of this study was the successful utilization of the positively charged nanocrystals (NCs) of Tedizolid Phosphate (TZP) (0.1% w/v) for topical ocular applications.
Abdullah Alshememry, Musaed Alkholief, Mohd Abul Kalam, Mohammad Raish, Raisuddin Ali, Sulaiman S. Alhudaithi, Muzaffar Iqbal, Aws Alshamsan   +7 more
doaj   +1 more source

Subinhibitory concentrations of tedizolid induce upregulation of virulence gene transcription in Staphylococcus aureus

Journal of Infection in Developing Countries
Introduction: Sub-minimal inhibitory concentrations (sub-MICs) of antibiotics can modulate the expression of virulence factors in bacterial pathogens.
Han Yang, Wen Lin, Chunyan He, Wen Shu, Wenjing Chen, Qingzhong Liu   +5 more
doaj   +1 more source

Efficacy and Safety of Tedizolid and Linezolid for the Treatment of Acute Bacterial Skin and Skin Structure Infections in Injection Drug Users: Analysis of Two Clinical Trials

Infectious Diseases and Therapy, 2018
Introduction Injection drug users (IDUs) often develop acute bacterial skin and skin structure infections (ABSSSI) and use emergency departments as their primary source for medical care.
Gregory J. Moran, Carisa De Anda, Anita F. Das, Sinikka Green, Purvi Mehra, Philippe Prokocimer   +5 more
doaj   +1 more source

Antibacterial activity of recently approved antibiotics against methicillin-resistant Staphylococcus aureus (MRSA) strains: A systematic review and meta-analysis

Annals of Clinical Microbiology and Antimicrobials, 2022
Background Methicillin-resistant Staphylococcus aureus (MRSA) infections are considered an important public health problem, and treatment options are limited.
Fei Liu, Sajad Rajabi, Chunhua Shi, Ghazale Afifirad, Nazanin Omidi, Ebrahim Kouhsari, Saeed Khoshnood, Khalil Azizian   +7 more
doaj   +1 more source