Results 41 to 50 of about 546 (157)

In vitro susceptibility of methicillin-resistant Staphylococcus aureus isolates from skin and soft tissue infections to vancomycin, daptomycin, linezolid and tedizolid

Brazilian Journal of Infectious Diseases, 2017
Introduction: Treatment of multidrug-resistant Gram-positive infections caused by Staphylococcus aureus remains as a clinical challenge due to emergence of new resistance mechanisms.
Johanna Marcela Vanegas Múnera, Ana María Ocampo Ríos, Daniela Montoya Urrego, Judy Natalia Jiménez Quiceno   +3 more
doaj   +1 more source

Subinhibitory concentrations of tedizolid induce upregulation of virulence gene transcription in Staphylococcus aureus

Journal of Infection in Developing Countries
Introduction: Sub-minimal inhibitory concentrations (sub-MICs) of antibiotics can modulate the expression of virulence factors in bacterial pathogens.
Han Yang, Wen Lin, Chunyan He, Wen Shu, Wenjing Chen, Qingzhong Liu   +5 more
doaj   +1 more source

Antibacterial activity of recently approved antibiotics against methicillin-resistant Staphylococcus aureus (MRSA) strains: A systematic review and meta-analysis

Annals of Clinical Microbiology and Antimicrobials, 2022
Background Methicillin-resistant Staphylococcus aureus (MRSA) infections are considered an important public health problem, and treatment options are limited.
Fei Liu, Sajad Rajabi, Chunhua Shi, Ghazale Afifirad, Nazanin Omidi, Ebrahim Kouhsari, Saeed Khoshnood, Khalil Azizian   +7 more
doaj   +1 more source

Perspectives of Positively Charged Nanocrystals of Tedizolid Phosphate as a Topical Ocular Application in Rabbits

Molecules, 2022
The aim of this study was the successful utilization of the positively charged nanocrystals (NCs) of Tedizolid Phosphate (TZP) (0.1% w/v) for topical ocular applications.
Abdullah Alshememry, Musaed Alkholief, Mohd Abul Kalam, Mohammad Raish, Raisuddin Ali, Sulaiman S. Alhudaithi, Muzaffar Iqbal, Aws Alshamsan   +7 more
doaj   +1 more source

Host–Pathogen Dual Targeting With Repurposed Drugs Identifies a Synergistic Therapy for Intracellular Staphylococcus aureus

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
A large intracellular drug‐repurposing screen identifies a potent synergy between 5‐fluoro‐2′‐deoxycytidine and rifapentine, acting through dual host–pathogen targeting to reduce Staphylococcus aureus burdens across strains, cell types, and infection models (created with BioRender).
Blanca Lorente‐Torres, Helena Á. Ferrero, Pablo Castañera, Jesús Llano‐Verdeja, Sergio Fernández‐Martínez, Amanda Herrero‐González, Farzaneh Javadimarand, Roberto López, Jesús F. Aparicio, Andrew M. Edwards, Volker Behrends, Luis M. Mateos, Álvaro Mourenza, Michal Letek   +13 more
wiley   +1 more source

Pharmacokinetic/pharmacodynamic analysis of tedizolid phosphate against Staphylococcus aureus and Streptococcus pneumoniae in children, adolescents, and adults by Monte Carlo simulation

Journal of Global Antimicrobial Resistance
Objective: The objective of this study was to investigate the cumulative fraction of response of various dosage regimens of tedizolid phosphate against Staphylococcus aureus and Streptococcus pneumoniae in children, adolescents, and adults.
Xiao-Chen Wei, Ming-Feng Zhao, Hai-Rong Lv, Xia Xiao   +3 more
doaj   +1 more source

Antibiotic Resistance: A Genetic and Physiological Perspective

MedComm, Volume 6, Issue 11, November 2025.
The development of resistance to antimicrobials and their historical progression are depicted in this graphic. It draws attention to important biochemical, physiological, and genetic factors that contribute to AMR, such as the transmission of genes, the development of biofilms, and the inactivation of antibiotics.
Rania G. Elbaiomy, Ahmed H. El‐Sappah, Rong Guo, Xiaoling Luo, Shiyuan Deng, Meifang Du, Xiaohong Jian, Mohammed Bakeer, Zaixin Li, Zhi Zhang   +9 more
wiley   +1 more source

Pharmacokinetics of Tedizolid in Adults with Cystic Fibrosis [PDF]

Open Forum Infectious Diseases, 2017
Abstract Background The presence of MRSA in the airways of patients with CF is associated with more rapid lung function decline and a higher mortality. Tedizolid (TDZ) is an oxazolidinone antibiotic with potent activity against MRSA; however, the pharmacokinetics (PK) in CF have not been described ...
Joshua Wang, Jenny Park, Jordanna Jayne, Timothy Bensman, David D’Argenio, Lynn Fukushima, Adupa Rao, Paul Beringer   +7 more
openaire   +1 more source

In vitro activity of tedizolid against the Mycobacterium abscessus complex

, 2018
International audienceInfections due to Mycobacterium abscessus carry a poor prognosis since this rapidly growing mycobacterium is intrinsically resistant to most antibiotics.
Michel Arthur, Vincent Dubée, Daria Soroka, Heym, Beate, Herrmann, Jean-Louis, J.L. Gaillard, Delphine Dorchène, Compain, Fabrice, Arthur, Michel, Beate Heym, Jean-Louis Gaillard, Dorchène, Delphine, Fabrice Compain, Dubée, Vincent, V. Dubée, J.L. Herrmann, D. Dorchène, Gaillard, Jean-Louis, F. Compain, B. Heym, D. Soroka, M. Arthur, Soroka, Daria, Jean-Louis Herrmann   +23 more
core   +1 more source

Efficacy and Safety of Tedizolid and Linezolid for the Treatment of Acute Bacterial Skin and Skin Structure Infections in Injection Drug Users: Analysis of Two Clinical Trials

Infectious Diseases and Therapy, 2018
Introduction Injection drug users (IDUs) often develop acute bacterial skin and skin structure infections (ABSSSI) and use emergency departments as their primary source for medical care.
Gregory J. Moran, Carisa De Anda, Anita F. Das, Sinikka Green, Purvi Mehra, Philippe Prokocimer   +5 more
doaj   +1 more source