Results 51 to 60 of about 546 (157)

Stability of tedizolid phosphate-sodium rifampicin and tedizolid phosphate-meropenem admixtures in intravenous infusion bags stored at different temperatures

Die Pharmazie, 2020
This is a report on the chemical stability and physical compatibility of intravenous tedizolid phosphate 0.8 mg/mL-sodium rifampicin 2.4 mg/mL and tedizolid phosphate 0.8 mg/mL–meropenem 4 mg/mL combinations in polypropylene 0.9% sodium chloride infusion bags stored at different storage conditions.
Ezquer-Garin, C., Ferriols-Lisart, R., Martinez-López, L. M., Sangrador-Pelluz, C., Nicolás-Picó, J., Alós-Alminana, M.   +5 more
openaire   +2 more sources

Bezlotoxumab as Treatment for Recurrent/Chronic Clostridioides difficile Infection in Pediatric Stem Cell Transplant Recipients: A Multi‐Institutional Experience

Pediatric Blood &Cancer, Volume 72, Issue 10, October 2025.
ABSTRACT Clostridioides difficile infection (CDI) represents a significant health risk to pediatric stem cell transplant (SCT) patients. In these patients, recurrent CDI is common, requiring prolonged antibiotic usage and increased hospitalization. Bezlotoxumab, a monoclonal antibody that targets the toxin responsible for CDI, has demonstrated efficacy
Aaron E. Fan, Shaikha Alqahtani, Natalie Dailey Garnes, Priti Tewari, Demetrios Petropoulos, Sajad Khazal, Kris Mahadeo, Paige DePriest, Irtiza N. Sheikh   +8 more
wiley   +1 more source

Linezolid‐Associated Lactic Acidosis Triggering a Sepsis Alert: A Case Report

Clinical Case Reports, Volume 13, Issue 9, September 2025.
ABSTRACT Elevated lactate alone may trigger false sepsis alerts. In this case, linezolid‐induced lactic acidosis mimicked sepsis, triggering automated alerts. Clinicians should consider medication‐related causes of lactate elevation and apply clinical context in interpreting automated alerts to avoid unnecessary interventions, alert fatigue, and ...
Yusuf Kagzi, Moni Roy, Tulika Chatterjee
wiley   +1 more source

Influence of tedizolid on the cytokine response to the endotoxin challenge in healthy volunteers: a cross-over trial

, 2022
Background Preclinical data suggested anti-inflammatory properties of tedizolid. Objectives To investigate the influence of tedizolid on the cytokine response to the human endotoxin challenge and the effect of endotoxaemia on the pharmacokinetics and ...
Dorn, Christoph, Matzneller, Peter, Jilma, Bernd, Jorda, Anselm, Lackner, Edith, Wölf-Duchek, Michael, Al Jalali, Valentin, Schörgenhofer, Christian, Zeitlinger, Markus, Wulkersdorfer, Beatrix, Bauer, Martin   +10 more
core   +1 more source

Development of Bisphosphonate-Conjugated Antibiotics to Overcome Pharmacodynamic Limitations of Local Therapy: Initial Results with Carbamate Linked Sitafloxacin and Tedizolid

Antibiotics, 2021
The use of local antibiotics to treat bone infections has been questioned due to a lack of clinical efficacy and emerging information about Staphylococcus aureus colonization of the osteocyte-lacuno canalicular network (OLCN).
Emmanuela Adjei-Sowah, Yue Peng, Jason Weeks, Jennifer H. Jonason, Karen L. de Mesy Bentley, Elysia Masters, Yugo Morita, Gowrishankar Muthukrishnan, Philip Cherian, X. Eric Hu, Charles E. McKenna, Frank H. Ebetino, Shuting Sun, Edward M. Schwarz, Chao Xie   +14 more
doaj   +1 more source

Facile Synthesis of Oxazolidinones as Potential Antibacterial Agents

ChemistryOpen, Volume 14, Issue 7, July 2025.
A microwave‐assisted method synthesizes novel oxazolidinone analogues via a proline‐initiated three‐component Mannich reaction and subsequent cyclization. The resulting analogues show antibacterial activity against M. smegmatis, with a minimum MIC of 8 mg/L, which is comparable to Rifampicin.
Secret P. Els, Kimberleigh B. Govender, Mxolisi K. Sokhela, Nilay Bhatt, Nakita Reddy, Hendrik G. Kruger, Per I. Arvidsson, Hendra Gunosewoyo, Thavendran Govender, Tricia Naicker   +9 more
wiley   +1 more source

Is there a role for tedizolid in the treatment of non-tuberculous mycobacterial disease?

, 2019
Background: Pulmonary infections caused by non-tuberculous mycobacteria (NTM) are hard to treat and have low cure rates despite intensive multidrug therapy.
Koeken, Valerie ACM, Hoefsloot, Wouter, Pennings, L.J., Pennings, Lian J, Pennings, Lian J., van Ingen, Jakko, Svensson, E.M., Svensson, Elin, Koeken, Valerie A. C. M., Hoefsloot, W., Wertheim, Heiman FL, Ruth, M.M., Ingen, J. van, Koeken, V.A.C.M., Svensson, Elin M, Ruth, Mike Marvin, Wertheim, Heiman F. L., Wertheim, H.F.L.   +17 more
core   +1 more source

Quantification of Oseltamivir Phosphate Enantiomeric Impurity by Chiral HPLC Method With the Aid of Solvent Extraction and Phosphate Salt‐Out Method

Chirality, Volume 37, Issue 5, May 2025.
In this method, oseltamivir phosphate enantiomeric impurity is quantified through the chiral HPLC method by removal of phosphate salt through solvent extraction coupled with the salt‐out method. Chiral HPLC confirms the presence of drugs and impurities in the organic layer.
Torati Srinivas, K. V. N. Suresh Reddy, Challa Madhavi, M. Kiranmai Reddy   +3 more
wiley   +1 more source

Dual-Drug Delivery via Zein In Situ Forming Implants Augmented with Titanium-Doped Bioactive Glass for Bone Regeneration: Preparation, In Vitro Characterization, and In Vivo Evaluation

Pharmaceutics, 2022
In situ forming implants (IFIs) are non-surgical approach using biodegradable polymers to treat bone fractures. The study aimed at preparing dual-drug-loaded IFIs to deliver pitavastatin (osteogenic drug) and tedizolid (antibiotic) using zein as the ...
Alaa Emad Eldeeb, Salwa Salah, Mostafa Mabrouk, Mohammed S. Amer, Nermeen A. Elkasabgy   +4 more
doaj   +1 more source

A review of antibiotic safety in pregnancy—2025 update

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 45, Issue 4, Page 227-237, April 2025.
Abstract Antibiotics constitute the majority of prescriptions for women during pregnancy. Common bacterial infections, including urinary tract infections, skin and soft tissue infections, and upper and lower respiratory tract infections, are expected in pregnancy, similar to the general public.
Johny Nguyen, Victoria Madonia, Christopher M. Bland, Kayla R. Stover, Lea S. Eiland, Julia Keating, Madeline Lemmon, P. Brandon Bookstaver, as part of the Southeastern Research Group Endeavor (SERGE‐45) research network   +8 more
wiley   +1 more source