Results 51 to 60 of about 1,804 (172)

Quantification of Oseltamivir Phosphate Enantiomeric Impurity by Chiral HPLC Method With the Aid of Solvent Extraction and Phosphate Salt‐Out Method

Chirality, Volume 37, Issue 5, May 2025.
In this method, oseltamivir phosphate enantiomeric impurity is quantified through the chiral HPLC method by removal of phosphate salt through solvent extraction coupled with the salt‐out method. Chiral HPLC confirms the presence of drugs and impurities in the organic layer.
Torati Srinivas, K. V. N. Suresh Reddy, Challa Madhavi, M. Kiranmai Reddy   +3 more
wiley   +1 more source

Effect of the human endotoxin challenge on tedizolid tissue penetration

British Journal of Clinical Pharmacology, 2022
The effects of the human endotoxin challenge on tissue pharmacokinetics are unknown. In the present study, we aimed to assess the effect of the endotoxin challenge on interstitial fluid pharmacokinetics of tedizolid in healthy volunteers using intramuscular microdialysis. Eight healthy male subjects were treated with 200 mg of tedizolid phosphate for 6 
Anselm Jorda, Beatrix Wulkersdorfer, Christian Schoergenhofer, Peter Matzneller, Valentin al Jalali, Martin Bauer, Michael Wölfl‐Duchek, Edith Lackner, Christoph Dorn, Bernd Jilma, Markus Zeitlinger   +10 more
openaire   +2 more sources

A review of antibiotic safety in pregnancy—2025 update

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 45, Issue 4, Page 227-237, April 2025.
Abstract Antibiotics constitute the majority of prescriptions for women during pregnancy. Common bacterial infections, including urinary tract infections, skin and soft tissue infections, and upper and lower respiratory tract infections, are expected in pregnancy, similar to the general public.
Johny Nguyen, Victoria Madonia, Christopher M. Bland, Kayla R. Stover, Lea S. Eiland, Julia Keating, Madeline Lemmon, P. Brandon Bookstaver, as part of the Southeastern Research Group Endeavor (SERGE‐45) research network   +8 more
wiley   +1 more source

Determination of Tedizolid in Bacterial Growth Medium Mueller-Hinton Broth by High-Performance Liquid Chromatography and Its Application to an In Vitro Study in the Hollow-Fiber Infection Model

Separations, 2021
Pharmacokinetic/pharmacodynamic (PKPD) studies of anti-infectives are frequently performed in in vitro infection models where accurate quantification of antibiotic concentrations in bacterial growth media is crucial to establish PK/PD relationships. Here,
Khalid Iqbal, Aliki Milioudi, Elena Haro Martínez, Sebastian Georg Wicha   +3 more
doaj   +1 more source

Complicated and deep bacterial skin and soft tissue infections

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 23, Issue 3, Page 357-375, March 2025.
Summary Complicated erysipelas, cellulitis, and necrotizing soft tissue infections belong to the spectrum of bacterial infections affecting the skin and underlying soft tissues. Their frequency as well as risk of recurrence and complicated disease course pose a significant health burden.
Christine Prodinger, Arno Lechner, Arno Hintersteininger, Jan Marco Kern, Matthias Meißnitzer, Damian Meyersburg, Johann W. Bauer, Martin Laimer   +7 more
wiley   +1 more source

Komplizierte und tiefe bakterielle Haut‐ und Weichteilinfektionen

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 23, Issue 3, Page 357-376, March 2025.
Zusammenfassung Komplizierte Erysipele, Phlegmone und nekrotisierende Weichteilinfektionen sind bakterielle Haut‐ und Weichteilinfektionen (BHWI), die aufgrund ihrer Häufigkeit, der Neigung zu Rezidiven und dem Auftreten komplizierter Verläufe ein bedeutendes Gesundheitsproblem darstellen.
Christine Prodinger, Arno Lechner, Arno Hintersteininger, Jan Marco Kern, Matthias Meißnitzer, Damian Meyersburg, Johann W. Bauer, Martin Laimer   +7 more
wiley   +1 more source

Profile of tedizolid phosphate and its potential in the treatment of acute bacterial skin and skin structure infections

Infection and Drug Resistance, 2015
Ronald G Hall 2nd, Heidi N Michaels Texas Tech University Health Sciences Center, Dallas, TX, USA Abstract: Tedizolid phosphate is the first once-daily oxazolidinone approved by the United States Food and Drug Administration for the treatment of acute ...
Hall RG 2nd, Michaels HN
doaj  

In Vitro Activity of Tedizolid, Dalbavancin, and Ceftobiprole Against Clostridium difficile

Frontiers in Microbiology, 2018
Background:Clostridium difficile (C. difficile) is a major nosocomial pathogen that colonizes in the human gut. Recently, the U.S. FDA approved three new antimicrobial agents against gram-positive bacteria: Tedizolid, Dalbavancin, and Ceftobiprole.
Dana Binyamin, Dana Binyamin, Orna Nitzan, Orna Nitzan, Maya Azrad, Zohar Hamo, Zohar Hamo, Omry Koren, Avi Peretz, Avi Peretz   +9 more
doaj   +1 more source

Tedizolid – a new antibiotic to solve old problems: prospects for the treatment of complicated skin and soft tissue infections

Амбулаторная хирургия, 2019
The work describes  a new antibiotic from the oxazolidinone group – tedizolid.  The results  of the clinical studies have shown a high efficacy of tedizolid in complicated  skin and soft tissue infections.
A. V. Rodin, O. I. Agafonov
doaj  

Tolerance of Prolonged Oral Tedizolid for Prosthetic Joint Infections: Results of a Multicentre Prospective Study

Antibiotics, 2020
Objectives: Data on clinical and biological tolerance of tedizolid (TZD) prolonged therapy are lacking. Methods: We conducted a prospective multicentre study including patients with prosthetic joint infections (PJIs) who were treated for at least 6 weeks
Eric Senneville, Aurélien Dinh, Tristan Ferry, Eric Beltrand, Nicolas Blondiaux, Olivier Robineau   +5 more
doaj   +1 more source