Results 51 to 60 of about 3,270 (204)

Efficacy and Safety of Tedizolid and Linezolid for the Treatment of Acute Bacterial Skin and Skin Structure Infections in Injection Drug Users: Analysis of Two Clinical Trials

Infectious Diseases and Therapy, 2018
Introduction Injection drug users (IDUs) often develop acute bacterial skin and skin structure infections (ABSSSI) and use emergency departments as their primary source for medical care.
Gregory J. Moran, Carisa De Anda, Anita F. Das, Sinikka Green, Purvi Mehra, Philippe Prokocimer   +5 more
doaj   +1 more source

In Vitro Activity of Tedizolid against Mycobacterium tuberculosis [PDF]

Antimicrobial Agents and Chemotherapy, 2019
Tedizolid is a novel oxazolidinone with activities against Gram-positive microorganisms, including mycobacteria. We studied the in vitro activity of tedizolid against 120  Mycobacterium tuberculosis strains, including susceptible, first-line-resistant, and multidrug-resistant isolates.
Ruiz Martínez, P., Causse, Manuel, Vaquero Abellán, Manuel, Casal Román, Manuel   +3 more
openaire   +5 more sources

Linezolid‐Associated Lactic Acidosis Triggering a Sepsis Alert: A Case Report

Clinical Case Reports, Volume 13, Issue 9, September 2025.
ABSTRACT Elevated lactate alone may trigger false sepsis alerts. In this case, linezolid‐induced lactic acidosis mimicked sepsis, triggering automated alerts. Clinicians should consider medication‐related causes of lactate elevation and apply clinical context in interpreting automated alerts to avoid unnecessary interventions, alert fatigue, and ...
Yusuf Kagzi, Moni Roy, Tulika Chatterjee
wiley   +1 more source

Pulmonary Disposition of Tedizolid following Administration of Once-Daily Oral 200-Milligram Tedizolid Phosphate in Healthy Adult Volunteers [PDF]

Antimicrobial Agents and Chemotherapy, 2012
ABSTRACT This study assessed the pulmonary disposition of tedizolid, an oxazolidinone, in adult volunteers receiving 200 mg of the prodrug tedizolid phosphate orally every 24 h for 3 days to steady state. Plasma samples were collected over the dosing interval, and participants were randomized to undergo bronchoalveolar lavage ...
Seth T, Housman, J Samuel, Pope, John, Russomanno, Edward, Salerno, Eric, Shore, Joseph L, Kuti, David P, Nicolau   +6 more
openaire   +2 more sources

Facile Synthesis of Oxazolidinones as Potential Antibacterial Agents

ChemistryOpen, Volume 14, Issue 7, July 2025.
A microwave‐assisted method synthesizes novel oxazolidinone analogues via a proline‐initiated three‐component Mannich reaction and subsequent cyclization. The resulting analogues show antibacterial activity against M. smegmatis, with a minimum MIC of 8 mg/L, which is comparable to Rifampicin.
Secret P. Els, Kimberleigh B. Govender, Mxolisi K. Sokhela, Nilay Bhatt, Nakita Reddy, Hendrik G. Kruger, Per I. Arvidsson, Hendra Gunosewoyo, Thavendran Govender, Tricia Naicker   +9 more
wiley   +1 more source

Development of Bisphosphonate-Conjugated Antibiotics to Overcome Pharmacodynamic Limitations of Local Therapy: Initial Results with Carbamate Linked Sitafloxacin and Tedizolid

Antibiotics, 2021
The use of local antibiotics to treat bone infections has been questioned due to a lack of clinical efficacy and emerging information about Staphylococcus aureus colonization of the osteocyte-lacuno canalicular network (OLCN).
Emmanuela Adjei-Sowah, Yue Peng, Jason Weeks, Jennifer H. Jonason, Karen L. de Mesy Bentley, Elysia Masters, Yugo Morita, Gowrishankar Muthukrishnan, Philip Cherian, X. Eric Hu, Charles E. McKenna, Frank H. Ebetino, Shuting Sun, Edward M. Schwarz, Chao Xie   +14 more
doaj   +1 more source

Consolidating Russia and Eurasia Antibiotic Resistance Data for 1992–2014 Using Search Engine [PDF]

, 2016
Background: The World Health Organization recognizes the antibiotic resistance problem as a major health threat in the 21st century. The paper describes an effort to fight it undertaken at the verge of two industries - healthcare and Data Science. One of
Alexander Bedenkov, Evgeniy Riabenko, Evgeny Sokolov, Nikolay Suvorov, Vitaly Shpinev   +4 more
core   +2 more sources

Quantification of Oseltamivir Phosphate Enantiomeric Impurity by Chiral HPLC Method With the Aid of Solvent Extraction and Phosphate Salt‐Out Method

Chirality, Volume 37, Issue 5, May 2025.
In this method, oseltamivir phosphate enantiomeric impurity is quantified through the chiral HPLC method by removal of phosphate salt through solvent extraction coupled with the salt‐out method. Chiral HPLC confirms the presence of drugs and impurities in the organic layer.
Torati Srinivas, K. V. N. Suresh Reddy, Challa Madhavi, M. Kiranmai Reddy   +3 more
wiley   +1 more source

Pharmacokinetic/pharmacodynamic analysis of tedizolid phosphate against Staphylococcus aureus and Streptococcus pneumoniae in children, adolescents, and adults by Monte Carlo simulation

Journal of Global Antimicrobial Resistance
Objective: The objective of this study was to investigate the cumulative fraction of response of various dosage regimens of tedizolid phosphate against Staphylococcus aureus and Streptococcus pneumoniae in children, adolescents, and adults.
Xiao-Chen Wei, Ming-Feng Zhao, Hai-Rong Lv, Xia Xiao   +3 more
doaj   +1 more source

Comparison of the in vitro activity of linezolid, tedizolid, sutezolid, and delpazolid against rapidly growing mycobacteria isolated in Beijing, China

International Journal of Infectious Diseases, 2021
Background: The natural resistance of rapidly growing mycobacteria (RGM) to multiple antibiotics renders the treatment of the infections caused less successful.
Shu’an Wen, Xiaopan Gao, Weijie Zhao, Fengmin Huo, Guanglu Jiang, Lingling Dong, Liping Zhao, Fen Wang, Xia Yu, Hairong Huang   +9 more
doaj   +1 more source