Results 1 to 10 of about 161,718 (344)

Clinical Implication of Targeting of Cancer Stem Cells [PDF]

, 2012
The existence of cancer stem cells (CSCs) is receiving increasing interest particularly due to its potential ability to enter clinical routine. Rapid advances in the CSC field have provided evidence for the development of more reliable anticancer ...
Al-Hajj M, Bao S, Bardsley MR, Barlogie B, Bentzen SM, Bertout JA, Blazek ER, Bruns CJ, Brunsvig PF, C.J. Bruns, Cao X, Chen MS, Clayton S, Collins AT, Cortes J, Costello R, Dalerba P, Diehn M, Dou J, Dylla SJ, Eyler CE, Fischer S, Garvalov BK, Ghiaur G, Gibbs CP, Gilbert CA, H. Niess, Haferlach T, Hochhaus A, Hosen N, Huff CA, Hurwitz H, Jiang X, Jones RJ, Jones RJ, Jones RJ, Ju Z, K.-W. Jauch, Kanamori M, Kiladjian JJ, Klonisch T, Kojima T, Korpal M, L. Zhao, Li C, Liu G, Liu R, Liu S, Lonardo E, Mauro MJ, McDermott SP, Merante S, Mimeault M, Moserle L, O’Brien SG, Park CY, Phillips TM, Platet N, Q. Bao, Rasheed ZA, Reya T, Reya T, Richardson GD, Roeder I, Seidel S, Singh A, Singh SK, Strojnik T, Stupp R, Suh MR, Szotek PP, Tang C, Tang M, Todaro M, Tu LC, Vermeulen L, Wilson BJ, Wright MH, Xu N, Y. Zhao, Yu F, Zhao C, Zhou BB   +82 more
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Measuring vertebrate telomeres: applications and limitations [PDF]

, 2004
Telomeres are short tandem repeated sequences of DNA found at the ends of eukaryotic chromosomes that function in stabilizing chromosomal end integrity.
Allsopp RC, Barja G, Benetos A, Broccoli D, Chang E, Charnov E, Friedrich U, Gemmell NJ, Girondot M, Grant JD, Harley CB, IUCN, Jeanclos E, Kern S, Lambertsen RH, Meyne J, Miyashita N, Ogburn CE, Olsen E, Prowse KR, Rose MR, Slagboom PE, Stearns SC, Stearns SC, Turker M, Vaziri H, Watson J, Zeichner SL   +27 more
core   +1 more source

Telomerase deficiency affects the formation of chromosomal translocations by homologous recombination in Saccharomyces cerevisiae. [PDF]

PLoS ONE, 2008
Telomerase is a ribonucleoprotein complex required for the replication and protection of telomeric DNA in eukaryotes. Cells lacking telomerase undergo a progressive loss of telomeric DNA that results in loss of viability and a concomitant increase in ...
Damon H Meyer, Adam M Bailis
doaj   +1 more source

The correlation between telomerase activity and BaX/BcL-2 ratio in valproic acid-treated MCF-7 breast cancer cell line [PDF]

, 2015
Objective(s): Valproic acid (VPA), a drug used in the treatment of neurological disorders, has been shown to have cytotoxic effects on cancer cells through different mechanisms.
Asadi, J., Gharaei, R., Vafaiyan, Z.
core   +2 more sources

Fluorescence-guided surgery of a highly-metastatic variant of human triple-negative breast cancer targeted with a cancer-specific GFP adenovirus prevents recurrence. [PDF]

, 2016
We have previously developed a genetically-engineered GFP-expressing telomerase-dependent adenovirus, OBP-401, which can selectively illuminate cancer cells.
Bouvet, Michael, Fujiwara, Toshiyoshi, Hoffman, Robert M, Kagawa, Shunsuke, Kishimoto, Hiroyuki, Miwa, Shinji, Takehara, Kiyoto, Tazawa, Hiroshi, Urata, Yasuo, Yano, Shuya   +9 more
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Renal fibroblasts are involved in fibrogenic changes in kidney fibrosis associated with dysfunctional telomeres

Experimental and Molecular Medicine
Tubulointerstitial fibrosis associated with chronic kidney disease (CKD) represents a global health care problem. We previously reported that short and dysfunctional telomeres lead to interstitial renal fibrosis; however, the cell-of-origin of kidney ...
Sarita Saraswati, Paula Martínez, Rosa Serrano, Diego Mejías, Osvaldo Graña-Castro, Ruth Álvarez Díaz, Maria A. Blasco   +6 more
doaj   +1 more source

Assessing the Epigenetic Status of Human Telomeres [PDF]

, 2019
The epigenetic modifications of human telomeres play a relevant role in telomere functions and cell proliferation. Therefore, their study is becoming an issue of major interest.
Vaquero Sedas, María Isabel, Vega Palas, Miguel Ángel   +1 more
core   +1 more source

Autophagy Overactivity Regulate Terf1 and Terf2 in Positive and Negative-Telomerase Cancer Cell Lines [PDF]

, 2021
mohammad panahi, Saeed Samani, Nasrin Mohajeri, Akram Sadat Tabatabee Bafroee, Kazem Baesi, Asghar Abdoli   +5 more
openalex   +1 more source

Pathways and Mechanisms that Prevent Genome Instability in Saccharomyces cerevisiae. [PDF]

, 2017
Genome rearrangements result in mutations that underlie many human diseases, and ongoing genome instability likely contributes to the development of many cancers.
Kolodner, Richard D, Putnam, Christopher D   +1 more
core   +1 more source

Arabidopsis RecQl4A suppresses homologous recombination and modulates DNA damage responses [PDF]

, 2005
The DNA damage response and DNA recombination are two interrelated mechanisms involved in maintaining the integrity of the genome, but in plants they are poorly understood.
Bachrati, Bagherieh-Najjar, Bai, Blackburn, Bundock, Cohen, Courcelle, Cromie, De Silva, Dellaporta, Ellis, Fitzgerald, Frei, Gallego, Gallego, Gallego, Gherbi, Gray, Hanada, Hanin, Harrigan, Hartung, Henson, Imamura, Jackson, Jacques Hille, Johnson, Kitao, Krysan, Li, Lovett, Lowndes, McGlynn, McHugh, Mengiste, Michel, Mohammad B. Bagherieh-Najjar, Nakayama, Nakayama, Nugent, Onno M.H. Vries, Osborn, Pastink, Paul P. Dijkwel, Pierce, Puchta, Reiss, Riha, Riha, Rothstein, Sambrook, Seigneur, Sengupta, Sessions, Simon, Sinclair, Sladek, Sundaresan, Swoboda, Tercero, Ui, Valvekens, Watt, Wu, Yamagata   +64 more
core   +3 more sources