Results 11 to 20 of about 161,718 (344)

Is telomerase reactivation associated with the down-regulation of TGF β receptor-II expression in human breast cancer? [PDF]

Cancer Cell International, 2003
Background Telomerase is a ribonucleoprotein that synthesizes telomeres and plays an important role in chromosomal stability and cellular immortalisation. Telomerase activity is detectable in most human cancers but not in normal somatic cells.
Thomas Valene, Newbold Robert F, Elkak Abd E, Mokbel Kefah   +3 more
doaj   +4 more sources

Recent progress in human telomerase structure and its therapeutic targeting [PDF]

Frontiers in Molecular Biosciences
Most cancer and stem cells activate telomerase to preserve critical genetic material during cell division. Telomerase is a reverse transcriptase ribonucleoprotein that adds telomeric repeats to chromosome ends, thus overcoming the end-replication problem.
Muaath Ebrahim Almansoori, Abdulrahman Awad, Sarah Dhaiban, Mohammed Turki Alduhoori, Humayun Sharif, Abdulrahim Sajini   +5 more
doaj   +2 more sources

Therapeutic 6-thio-deoxyguanosine inhibits telomere elongation in cancer cells by inducing a non-productive stalled telomerase complex [PDF]

Nature Communications
Most cancers upregulate the telomere lengthening enzyme telomerase to achieve unlimited cell division. How chemotherapeutic nucleoside 6-thio-2’-deoxyguanosine (6-thio-dG) targets telomerase to inhibit telomere maintenance in cancer cells and tumors was ...
Samantha L. Sanford, Mareike Badstübner, Michael Gerber, William Mannherz, Noah Lampl, Rachel Dannenberg, Angela Hinchie, Matthew A. Schaich, Sua Myong, Mark Hedglin, Suneet Agarwal, Jonathan K. Alder, Michael D. Stone, Patricia L. Opresko   +13 more
doaj   +2 more sources

Extracellular vesicles for delivery of functional telomerase [PDF]

Cell Communication and Signaling
Background Telomerase, essential for maintaining chromosomal telomere integrity and preventing cellular senescence, represents a promising therapeutic target.
Yingying He, Yumeng Cui, Lijuan Wang, Wen Yang, Ruping Wang, Yanghua Li, Yue Ma, Yanli Lin, Xiaojie Wu, Long Cheng, Chengjiang Zhou, Youliang Wang   +11 more
doaj   +2 more sources

Current Insights to Regulation and Role of Telomerase in Human Diseases

Antioxidants, 2017
The telomerase ribonucleoprotein complex has a pivotal role in regulating the proliferation and senescence of normal somatic cells as well as cancer cells.
Mert Burak Ozturk, Yinghui Li, Vinay Tergaonkar   +2 more
doaj   +2 more sources

Dynamic telomerase gene suppression via network effects of GSK3 inhibition [PDF]

, 2009
<b>Background</b>: Telomerase controls telomere homeostasis and cell immortality and is a promising anti-cancer target, but few small molecule telomerase inhibitors have been developed. Reactivated transcription of the catalytic subunit hTERT
Bilsland, Alan E., Burns, Sharon, Cairney, Claire, Gomez-Roman, Natividad, Hammonds, Tim, Hoare, Stacey, Keith, W. Nicol, Lafferty-Whyte, Kyle, Plumb, Jane, Roffey, Jon, Stevenson, Katrina   +10 more
core   +16 more sources

Early differential responses elicited by BRAFV600E in adult mouse models

Cell Death and Disease, 2022
The BRAF gene is frequently mutated in cancer. The most common genetic mutation is a single nucleotide transition which gives rise to a constitutively active BRAF kinase (BRAFV600E) which in turn sustains continuous cell proliferation.
Giuseppe Bosso, Pablo Lanuza-Gracia, Sergio Piñeiro-Hermida, Merve Yilmaz, Rosa Serrano, Maria A. Blasco   +5 more
doaj   +1 more source

Structural basis of human telomerase recruitment by TPP1-POT1

Science, 2022
Telomerase maintains genome stability by extending the 3′ telomeric repeats at eukaryotic chromosome ends, thereby counterbalancing progressive loss caused by incomplete genome replication.
Zala Sekne, G. Ghanim, A. M. van Roon, Thi Hoang Duong Nguyen   +3 more
semanticscholar   +1 more source

Telomerase regulation [PDF]

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2012
The intimate connection between telomerase regulation and human disease is now well established. The molecular basis for telomerase regulation is highly complex and entails multiple layers of control. While the major target of enzyme regulation is the catalytic subunit TERT, the RNA subunit of telomerase is also implicated in telomerase control.
Catherine, Cifuentes-Rojas, Dorothy E, Shippen   +1 more
openaire   +2 more sources

Consequences of telomere dysfunction in fibroblasts, club and basal cells for lung fibrosis development

Nature Communications, 2022
Telomere dysfunction induced by TRF1 depletion in fibroblasts, club and basal cells did not lead to interstitial lung fibrosis, underscoring alveolar type II cells as the relevant cell type in pulmonary fibrosis.
Sergio Piñeiro-Hermida, Paula Martínez, Giuseppe Bosso, Juana María Flores, Sarita Saraswati, Jane Connor, Raphael Lemaire, Maria A. Blasco   +7 more
doaj   +1 more source