Results 21 to 30 of about 161,718 (344)
ACS Chemical Biology, 2007 The control of telomerase activity at chromosome ends by telomere-binding proteins is critical for telomere length homeostasis. Two recent papers identify TPP1 as a critical mediator of this control. TPP1 forms part of the telomeric shelterin complex while also associating with telomerase, stimulating its activity and processivity.
Gaël, Cristofari +2 more
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Cost-Effective Trap qPCR Approach to Evaluate Telomerase Activity: an Important Tool for Aging, Cancer, and Chronic Disease Research [PDF]
Clinics, 2021 OBJECTIVES: Telomeres are a terminal “DNA cap” that prevent chromosomal fusion and degradation. However, aging is inherent to life, and so is the loss of terminal sequences.
Thalyta Nery Carvalho Pinto +4 more
doaj +1 more source
Molecular Oncology, 2021 Telomerase reverse transcriptase (TERT) maintains telomere homeostasis, thus ensuring chromosome stability and cell proliferation. In addition, several telomere‐independent functions of human TERT have been described.
Manuel Bernabé‐García +8 more
doaj +1 more source
Telomerase Regulation: A Role for Epigenetics
Cancers, 2021 Simple Summary Maintenance of telomeres is a fundamental step in human carcinogenesis and is primarily regulated by telomerase and the human telomerase reverse transcriptase gene (TERT).
Fatma Doğan, N. Forsyth
semanticscholar +1 more source
Telomerase RNA function in recombinant Tetrahymena telomerase [PDF]
Genes & Development, 1999 Telomerase is a ribonucleoprotein reverse transcriptase specialized for use of a sequence within its integral RNA component as the template for DNA synthesis. Telomerase adds telomeric simple sequence repeats to single-stranded primers in vitro or chromosome ends in vivo.
J D, Licht, K, Collins
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The mTOR pathway is necessary for survival of mice with short telomeres
Nature Communications, 2020 Telomerase deficiency leads to age-related diseases and shortened lifespan, while inhibition of the mTOR pathway delays aging. Here, the authors show that inhibition of mTORC1 signaling shortens the lifespan of telomerase deficient mice.
Iole Ferrara-Romeo +10 more
doaj +1 more source
eLife, 2019 The mechanisms that regulate pluripotency are still largely unknown. Here, we show that Telomere Repeat Binding Factor 1 (TRF1), a component of the shelterin complex, regulates the genome-wide binding of polycomb and polycomb H3K27me3 repressive marks to
Rosa María Marión +7 more
doaj +1 more source
Tel1ATM dictates the replication timing of short yeast telomeres [PDF]
, 2014 Telomerase action is temporally linked to DNA replication. Although yeast telomeres are normally late replicating, telomere shortening leads to early firing of subtelomeric DNA replication origins.
Alessandro Bianchi +4 more
core +7 more sources
TARGETING TELOMERASE FOR CANCER THERAPY
Oncogene, 2020 Telomere maintenance via telomerase reactivation is a nearly universal hallmark of cancer cells which enables replicative immortality. In contrast, telomerase activity is silenced in most adult somatic cells.
Adam N. Guterres, J. Villanueva
semanticscholar +1 more source
Current Opinion in Structural Biology, 2014 The telomerase reverse transcriptase has an essential role in telomere maintenance and in cancer biology. Progress during the last year has revealed the three-dimensional architecture of both human and ciliate telomerase at about 25Å resolution, obtained using single particle electron microscopy (EM).
Sandin, Sara, Rhodes, Daniela
openaire +2 more sources