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Telomere Length Abnormality: Investigating Approaches and Correlations with Cancer, Bone Marrow Failure and Hematological Malignancies [PDF]
BiomedicinesProper telomere maintenance is crucial for ensuring healthy cellular function. Telomeres have a tendency to reduce in length with cellular aging. Moreover several factors may promote telomere attrition.
Corrado Tarella +7 more
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Open Biology, 2022 Telomeres are nucleoprotein structures that cap the ends of linear chromosomes. Telomeric DNA comprises terminal tracts of G-rich tandem repeats, which are inherently difficult for the replication machinery to navigate.
Robert Lu, Hilda A. Pickett
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Telomere Length Measurement by Molecular Combing
Frontiers in Cell and Developmental Biology, 2020 Telomeres are repetitive regions of DNA bound by specialized proteins at the termini of linear chromosomes that prevent the natural chromosome ends from being recognized as DNA double strand breaks.
Vivian F. S. Kahl +7 more
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eLife, 2020 Telomeres are a significant challenge to DNA replication and are prone to replication stress and telomere fragility. The shelterin component TRF1 facilitates telomere replication but the molecular mechanism remains uncertain.
Rosa Maria Porreca +8 more
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Telomere length trajectory and its determinants in persons with coronary artery disease: longitudinal findings from the heart and soul study. [PDF]
PLoS ONE, 2010 Leukocyte telomere length, an emerging marker of biological age, has been shown to predict cardiovascular morbidity and mortality. However, the natural history of telomere length in patients with coronary artery disease has not been studied. We sought to
Ramin Farzaneh-Far +5 more
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Change in Leukocyte Telomere Length Predicts Mortality in Patients with Stable Coronary Heart Disease from the Heart and Soul Study. [PDF]
PLoS ONE, 2016 Short telomere length independently predicts mortality in patients with coronary heart disease. Whether 5-year change in telomere length predicts subsequent mortality in patients with coronary heart disease has not been evaluated.In a prospective cohort ...
Sarah E Goglin +5 more
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Telomere maintenance in African trypanosomes
Frontiers in Molecular Biosciences, 2023 Telomere maintenance is essential for genome integrity and chromosome stability in eukaryotic cells harboring linear chromosomes, as telomere forms a specialized structure to mask the natural chromosome ends from DNA damage repair machineries and to ...
Bibo Li, Bibo Li, Bibo Li, Bibo Li
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eLife, 2018 Chromosome replication and transcription occur within a complex nuclear milieu whose functional subdomains are beginning to be mapped out. Here we delineate distinct domains of the fission yeast nuclear envelope (NE), focusing on regions enriched for the
Hani Ebrahimi +3 more
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Inheritance of telomere length in a bird. [PDF]
PLoS ONE, 2011 Telomere dynamics are intensively studied in human ageing research and epidemiology, with many correlations reported between telomere length and age-related diseases, cancer and death. While telomere length is influenced by environmental factors there is
Thorsten Horn +5 more
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The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)
Nature Communications, 2019 ALT telomeres experience DNA damage that may drive recombination-based telomere elongation. Here, the authors reveal that FANCM plays a critical role in the suppression of ALT activity through its interaction with the BTR (BLM-TOP3A-RMI) complex.
Robert Lu +9 more
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