Results 171 to 180 of about 47,830 (278)
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, Volume 16, Issue 7, Page 1370-1386, July 2026.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
ESCO2 Interacts with TRF1/2 and Facilitates Telomere Maintenance. [PDF]
Int J Mol SciGuo J, Ji J, Liu J, Tang M.
europepmc +1 more source
Inhibition of the DNA Damage Pathway by a Telomere-Binding Protein
PLoS Biology, 2004 openaire +3 more sources
FEBS Open Bio, Volume 16, Issue 7, Page 1387-1399, July 2026.We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa +2 more
wiley +1 more source
Biogenesis and Regulation of Telomerase during Development and Cancer. [PDF]
Cold Spring Harb Perspect BiolChen L, Batista LFZ.
europepmc +1 more source
Characterizing telomere-binding protein Hmbox1a/b and Zbtb48 in zebrafish
Telomeres are nucleoprotein structures at the ends of linear chromosomes, bound by various proteins. Some of these proteins protect the telomere ends, such as the shelterin complex, while others help regulate telomere length. Recently, our lab has characterized two telomere-binding proteins, HMBOX1 and ZBTB48, in mammalian cell lines.
openaire +2 more sources
Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities
Advanced Science, Volume 13, Issue 39, 13 July 2026.ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal +3 more
wiley +1 more source
Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis
Advanced Science, Volume 13, Issue 37, 3 July 2026.This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou +23 more
wiley +1 more source
Mechanozyme: An Artificial Enzyme With a Mechanophore Framework
Advanced Science, Volume 13, Issue 39, 13 July 2026.Mechanical destabilization of a G‐quadruplex mechanophore in a DNAzyme markedly boosts its catalytic activity, demonstrating “mechanozymes” as artificial enzymes whose functions are modulated by mechanical stress exerted by ultrasonication. This mechanozyme principle is broadly applicable to control biomolecular activities.
Jiahao Ji +7 more
wiley +1 more source