Rare genetic diseases associated with G-quadruplex-induced replication stress. [PDF]
Commun BiolHerr LM +6 more
europepmc +1 more source
Hematological Oncology, Volume 44, Issue 4, July 2026.ABSTRACT Chronic lymphocytic leukemia (CLL) is a clinically and molecularly heterogeneous disease. PKMYT1, a G2/M cell cycle kinase, has been implicated in tumor progression in several cancers, but its role in CLL remains unclear. We evaluated PKMYT1 expression in primary CLL samples and analyzed associations with cytogenetic features and clinical ...
Elizabete Cristina Iseke Bispo +6 more
wiley +1 more source
Regulatory Mechanisms of Leaf Senescence in Herbaceous and Woody Perennials: A Comparative Review. [PDF]
Plants (Basel)Li W, Qi J.
europepmc +1 more source
Salivary Extracellular Vesicles: Paradigm Shift in Liquid Biopsy Diagnostics
Journal of Extracellular Biology, Volume 5, Issue 7, July 2026.ABSTRACT Extracellular vesicles (EVs), lipid bilayer nanoparticles released by virtually all cells, serve as essential messengers for intercellular communication. Due to their involvement in several pathophysiological processes, EVs have recently gained considerable attention as potentially diagnostic and prognostic biomarkers for various illnesses ...
Kwanele Xulu +3 more
wiley +1 more source
Cryo-electron microscopy structure of the budding yeast telomerase holoenzyme. [PDF]
ScienceHu H +6 more
europepmc +1 more source
Cross‐Level Regulatory Interactions Underlying Human Immune Aging
MedComm, Volume 7, Issue 7, July 2026.We performed multi‐omics sequencing on peripheral blood samples from 69 individuals aged 23–75 years and identified multi‐layered molecular interaction networks underlying the process of immune senescence, which provides a comprehensive multi‐omics framework for understanding immune aging and identifying potential strategies to delay immunosenescence ...
Quanyou Wu +9 more
wiley +1 more source
Cellular Senescence and Aging: Mechanisms, Disease Convergence, and Therapeutic Frontiers
MedComm, Volume 7, Issue 7, July 2026.This schematic illustrates the hierarchical and interconnected nature of the primary molecular hallmarks of aging. The progression of aging is driven by a convergence of intrinsic molecular insults. Within the nucleus, genomic instability and telomere attrition trigger persistent DDR, accompanied by extensive epigenetic alterations.
Guowei Cai +10 more
wiley +1 more source
Conditional deletion of human STN1 leads to telomere dysfunction, genome instability and proliferation defects. [PDF]
J Cell SciHolbrooks JS +8 more
europepmc +1 more source
<i>SBSPON</i> gene association with type 2 diabetes mellitus and its impact on leukocyte telomere length. [PDF]
Front Endocrinol (Lausanne)Sethi I +7 more
europepmc +1 more source
One Yeast, Sixteen Synthetic Chromosomes, Infinite Possibilities
Yeast, Volume 43, Issue 4, Page 143-158, July 2026.ABSTRACT The evolution of the yeast, Saccharomyces cerevisiae, from a genetically tractable model organism to a chassis for genome‐scale engineering represents one of the most influential trajectories in eukaryotic biology. The Synthetic Yeast Genome Project (Sc2.0) embodies the current height of this trajectory, having now delivered functional ...
Edward Archer +4 more
wiley +1 more source