Results 201 to 210 of about 47,830 (278)

Essential Role for Telomeric Repeat‐Binding Factor 2 in Cardiac Development and Function

FASEB BioAdvances, Volume 8, Issue 7, July 2026.
This schematic illustrates a paradigm shift in telomere biology, demonstrating that Trf2 is a mandatory orchestrator of heart development and function through pathways distinct from its canonical telomere protective role. ABSTRACT Telomere repeat‐binding factor 2 (Trf2) is essential for protecting our telomeres.
Ali Hakim Shoushtari, Aysenure Danis, Michael Wayne Stoner, Jeffrey Baust, Andrea Sebastiani, Paramesha Bugga, Janet R. Manning, Bellina A. S. Mushala, Nisha Bhattarai, Imad Al Ghouleh, Iain Scott, Maryam Sharifi‐Sanjani   +11 more
wiley   +1 more source

Tankyrases and Their Binding Proteins: Origins of Their Roles in Diverse Cellular Pathways. [PDF]

Cells
Chalabi Hagkarim N, Grand RJ.
europepmc   +1 more source

De Novo Genome Assemblies of Four Rainbow Trout Genetic Lines Reveal Structural Variants in Pursuit of a Pangenome Reference

Molecular Ecology Resources, Volume 26, Issue 5, July 2026.
ABSTRACT Rainbow trout (Oncorhynchus mykiss) exhibit extensive genomic diversity shaped by domestication, life history and geographic origin. To advance the development of a comprehensive pangenome reference, we present new de novo genome assemblies of two genetically and ecologically distinct lines: Whale Rock (WR; wild, landlocked, Central California)
Ali Ali, Geoffrey C. Waldbieser, Ramey C. Youngblood, Paul A. Wheeler, Brian E. Scheffler, Stuart Willis, Shawn R. Narum, Gary H. Thorgaard, Mohamed Salem, Yniv Palti   +9 more
wiley   +1 more source

The aging paradox of Cushing's syndrome: Stress without clear senescence? [PDF]

J Neuroendocrinol
Silveira IN, Guterres A.
europepmc   +1 more source

Cellular Heterogeneity During Arterial Aging

Aging Cell, Volume 25, Issue 7, July 2026.
Graphical abstract showing arterial cell subpopulations and their functional changes during aging. Transcriptomic profiling studies across species identify age‐associated endothelial, smooth muscle, fibroblast, and immune cell states characterized by inflammation, extracellular matrix remodeling, phenotypic switching, and cellular senescence ...
He Xu, Paul‐Lennard Mendez, Dimitri Kasakovski, Judith Sluimer   +3 more
wiley   +1 more source

A reference genome sequence for the exceptionally long-lived Great Basin bristlecone pine, Pinus longaeva. [PDF]

G3 (Bethesda)
Neale DB, Zimin AV, Millar CI, McGuire PE, Hosea JA, Li E, Puiu D, Timp W, Salzberg SL.   +8 more
europepmc   +1 more source

A Primate‐Specific lncRNA LINC01021 Contributes to Cellular and Organismal Aging via DAZAP1‐Dependent Destabilization of RBMX

Aging Cell, Volume 25, Issue 7, July 2026.
Primate‐specific lncRNA LINC01021 promotes aging by enhancing cellular senescence and accelerating aspects of organismal decline. Mechanistically, LINC01021 induces DAZAP1‐mediated destabilization of RBMX, activating the P53 pathway and establishing a primate‐specific regulatory axis in aging.
Yan Zhang, Li Hu, Xin Dong, Qinghua Zeng, Meiting Zi, Ayesha Nisar, Sawar Khan, Raoxian Bai, Chonghui Liu, Mingxia Ge, Shaoyan Pu, Gonghua Li, Yonghan He   +12 more
wiley   +1 more source

Orphan nuclear receptors recruit TRIM28 to promote telomeric H3K9me3 for the ALT pathway. [PDF]

EMBO J
Tsai CT, Gaela VM, Hsia HY, Huang YC, Shen YL, Chen LY.   +5 more
europepmc   +1 more source

Engineering Extracellular Vesicles for Anti‐Aging Therapy: Mechanisms, Applications, and Perspectives

Aging Cell, Volume 25, Issue 7, July 2026.
This review systematically elucidates the multifactorial anti‐aging mechanisms of extracellular vesicles (EVs). By bridging fundamental biology with advanced bioengineering, scalable manufacturing, and clinical translation, it establishes a comprehensive framework for developing next‐generation EVs‐based precision nanotherapeutics to combat systemic ...
Xian Huang, Qiujie Li, Guofang Tao, Xulin Gan, Jiangjie Lu, Sergei Krasny, Liyun Shi   +6 more
wiley   +1 more source

Epigenetic gene regulation is controlled by distinct regulatory complexes utilizing specialized paralogs of TELOMERE REPEAT BINDING FACTORS. [PDF]

PLoS Genet
Mendler M, Krause K, Zündorf S, Sannak P, Tänzler P, Stolze S, Nakagami H, Turck F.   +7 more
europepmc   +1 more source