Results 201 to 210 of about 77,771 (318)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, Volume 16, Issue 5, Page 1000-1019, May 2026.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Editorial: The Evolving Telomere

Frontiers in Genetics, 2016
Kurt W Runge, Arthur J Lustig
doaj   +1 more source

The Inner Nuclear Membrane Protein Bqt4 in Fission Yeast Contains a DNA-Binding Domain Essential for Telomere Association with the Nuclear Envelope [PDF]

, 2018
Chunyi Hu, Haruna Inoue, Wenqi Sun, Yumiko Takeshita, Yaoguang Huang, Ying Xu, Junko Kanoh, Yong Chen   +7 more
openalex   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, Volume 16, Issue 5, Page 857-869, May 2026.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Up-Regulation of Telomere-Binding Proteins, TRF1, TRF2, and TIN2 Is Related to Telomere Shortening during Human Multistep Hepatocarcinogenesis [PDF]

, 2005
Bong-Kyeong Oh, Young‐Joo Kim, Chanil Park, Young Nyun Park   +3 more
openalex   +1 more source

Pancancer Fine‐Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma

Advanced Science, Volume 13, Issue 25, 4 May 2026.
This study identifies mutation‐intolerant genes (MIGs), which are mutationally constrained in tumors despite normal‐tissue variability. Using miDriver, the authors pinpoint MIGs essential for tumor‐intrinsic fitness and immune evasion. Focusing on CHEK1, they show it drives tumor fitness and sculpts an immunosuppressive niche via the MIF–CD74 axis ...
Tao Wang, Hongyu Zhao, Xiaojie Sun, Yuqi Ding, Zhipeng Zhu, Xiaotong Yu, Rongyi Zhu, Dan Wang, Kailong Li, Yang Liu, Li‐Bin Wang, Xiaolu Zhao, Baojun Suo, Hongsen Bi, Peipei Zhang, Tong Liu, Fengbiao Mao   +16 more
wiley   +1 more source

Development and characterization of polyclonal antibodies against the linker region of the telomere-binding protein TRF2

, 2017
Nadya V. Ilicheva, Aleksandra O. Travina, A.P. Voronin, O. I. Podgornaya   +3 more
openalex   +1 more source

Single-Myb-histone proteins from Arabidopsis thaliana: a quantitative study of telomere-binding specificity and kinetics [PDF]

, 2008
Ctirad Hofr, Pavla Šultesová, Michal Zimmermann, Iva Mozgová, Petra Procházková Schrumpfová, Michaela Wimmerová, Jiřı́ Fajkus   +6 more
openalex   +1 more source

Nuclear Mechanotransduction Across the Metastatic Cascade: Decoding Spatiotemporal Heterogeneity in Cancer Dissemination

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Tumor metastasis results from complex interactions between cancer cells and mechanical microenvironments. We propose a “nucleus‐centered, cross‐stage mechanical signal decoding” model, highlighting how nuclear mechanosensors interpret forces at different stages.
Linqi Song, Jingyang Liu, Xue Wang, Minpu Zhang, Changgang Sun   +4 more
wiley   +1 more source

Tethering Telomeric Double- and Single-stranded DNA-binding Proteins Inhibits Telomere Elongation [PDF]

, 2008
Katherine T. Etheridge, Sarah A. Compton, Katharine S. Barrientos, Sezgin Özgür, Jack D. Griffith, Christopher M. Counter   +5 more
openalex   +1 more source