Results 211 to 220 of about 47,830 (278)

Interplay of the ENS and Microbiota With Murine Gut Epithelium‐Derived Organoids in Aging

Aging Cell, Volume 25, Issue 7, July 2026.
A gut organoid model was developed to study the impact of age‐related changes of the enteric nervous system (ENS) and microbiome on the integrity and trophic capacity of the intestinal epithelial barrier. Organoids reflected in vivo aging features, including altered epithelial integrity and changes in acetylcholine‐related enzyme activity.
Tinh Thi Nguyen, Dennis Schapelhouman, Katharina Fischer, Jia‐Xuan Chen, Mario Dejung, Fridolin Kielisch, Julia Varga, Johannes Piepgras, Matthew Ahn, Oliver Tüscher, Peter Baumann, Sandra Schick, Kristina Endres   +12 more
wiley   +1 more source

Protection of telomeres 1b safeguards the Arabidopsis genome by regulating ROS homeostasis. [PDF]

Nat Commun
Min JH, Castillo-González C, Barcenilla BB, Yeo IC, Xie X, Bose S, Ortiz-Morea FA, Liu D, Canal E, Curtis D, Yerram M, Shin J, Ulianich P, Phadke C, He P, Wierzbicki AT, Zhang J, Shakirov EV, Juenger TE, Shippen DE.   +19 more
europepmc   +1 more source

Age‐Associated Senescence of Decidual Macrophages: A Key Mediator of Adverse Pregnancy Outcomes in Advanced Maternal Age

Aging Cell, Volume 25, Issue 7, July 2026.
Decidual macrophages (DM) in advanced maternal age (AMA) exhibit FOXO3 deficiency‐driven senescence, further accelerated by elevated uterine IL‐6. This manifests as pro‐inflammatory polarization, increased senescence markers, reduced phagocytosis, and impaired trophoblast function.
Yujing Zhang, Yiming Zhang, Guangshun Gong, Zhijing Li, Wenjing Xiong, Xuhui Fang, Ning Lu, Di Wang, Yihui Li, Aihua Liao   +9 more
wiley   +1 more source

GW9508‐Induced Activation of GPR40 in Thymic Epithelial Cells: A Therapeutic Strategy to Delay Thymic Aging

Aging Cell, Volume 25, Issue 7, July 2026.
GW9508 activates GPR40 to trigger Ca2+ influx and AMPKα signaling, repressing ERK1/2‐MAPK cascade. This pathway alleviates thymic epithelial cell senescence and restores T cell production to counteract thymus aging. ABSTRACT Age‐associated thymic involution leads to a reduction of T‐cell production, which constitutes a primary factor in ...
Qingqing Li, Ping Zhu, Lihong Cui, Fenghua Luo, Yongqin Zhou, Yuanyuan Hu, Chunyan Luo, Shanshan Han, Xie Ding, Maoxi Yao, Honggang Yuan, Yinhong Song   +11 more
wiley   +1 more source

Updates on Mediterranean diet and health status: active ingredients and pharmacological mechanisms

British Journal of Pharmacology, Volume 183, Issue 13, Page 3484-3502, July 2026.
The Mediterranean diet (MedDiet) is among the most extensively studied dietary patterns and has been consistently associated with reduced risk of all‐cause mortality, cardiovascular disease, metabolic disorders, cognitive decline and several types of cancers.
Lukas Schwingshackl, Jakub Morze, Sabina Wallerer, Georg Hoffmann   +3 more
wiley   +1 more source

Minimal mutational requirements for conversion of a telomere resolvase into a Cre-like site-specific recombinase. [PDF]

PLoS One
Huang SH, Kobryn K.
europepmc   +1 more source

In Silico Drug Repositioning Identifies SYK Kinase Inhibitors as Potential Neuroprotective Agents for Ataxia–Telangiectasia

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
Repositioning of vemurafenib and palbociclib as spleen tyrosine kinase inhibitors for the treatment of neuroinflammation in Ataxia–Telangiectasia. ABSTRACT Ataxia–Telangiectasia (AT) is a rare neurodegenerative disorder characterized by progressive neuronal loss and chronic neuroinflammation.
Alessia Romano, Rocco Buccheri, Chiara Zagni, Antonio Rescifina   +3 more
wiley   +1 more source

Noncanonical chromosomal-end-specific telomeric repeat arrays in naturally telomerase-negative yeasts. [PDF]

Nucleic Acids Res
Brejová B, Hodorová V, Lichancová H, Gafurov A, Bujna D, Brázdovič F, Červenák F, Petrík T, Hegedűsová E, Forgáčová Jakúbková M, Neboháčová M, Tomáška Ľ, Sipiczki M, Vinař T, Nosek J.   +14 more
europepmc   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, Volume 293, Issue 13, Page 3717-3757, July 2026.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Iron-sulfur cofactors in nucleic acid metabolism and protein synthesis: Assembly, delivery, and putative roles in cellular and viral systems. [PDF]

J Biol Chem
Maio N, Rouault TA.
europepmc   +1 more source