Results 241 to 250 of about 77,771 (318)

Dyskerin dysfunction in cancer development: from telomere dysregulation to immune deficiency. [PDF]

Am J Cancer Res
Xie Y, Xue N, Xue L, Zeng X, Wang J, Zhang X.   +5 more
europepmc   +1 more source

Recombination suppression in plant adaptation and speciation

New Phytologist, Volume 250, Issue 4, Page 2061-2077, May 2026.
Summary Recombination suppression is increasingly recognized as an important facilitator of genomic divergence and speciation, especially under ongoing gene flow. In plants, however, the broader evolutionary consequences and the mechanisms by which recombination suppression arises and spreads are still incompletely understood, reflecting the inherent ...
Xu Zhang, Yisi Hu, Kaichi Huang, Stephen I. Wright, Loren H. Rieseberg   +4 more
wiley   +1 more source

Transcriptional regulation of telomeric repeat-containing RNA by the G-quadruplex-binding Ewing sarcoma protein. [PDF]

Sci Rep
Ulum LL, Matsudaira W, Yamanashi M, Shibata N, Saha S, Ishihara A, Oyoshi T.   +6 more
europepmc   +1 more source

A chromosome‐scale genome assembly of Hordeum erectifolium: genomic, transcriptomic and anatomical adaptations to drought in a wild barley relative

New Phytologist, Volume 250, Issue 4, Page 2652-2669, May 2026.
Summary Wild crop relatives are valuable genetic resources for improving stress adaptation in cultivated species, but their effective use depends on high‐quality reference genomes integrated with phenotypic and molecular datasets. Hordeum erectifolium, a wild relative of barley (H.
Einar Baldvin Haraldsson, Michael Anokye, Thea Rütjes, Helena Toegelová, Zuzana Tulpová, Hana Šimková, Jia‐Wu Feng, Martin Mascher, Maria von Korff   +8 more
wiley   +1 more source

A mechanism for telomere-specific telomere length regulation. [PDF]

Nucleic Acids Res
Teplitz GM, Pasquier E, Bonnell E, De Laurentiis E, Bartle L, Lucier JF, St-Laurent G, Dawson DS, Wellinger RJ.   +8 more
europepmc   +1 more source

Chromosome‐Scale Haplotype Genome Assemblies for the Australian Mango ‘Kensington Pride’ and a Wild Relative, Mangifera laurina, Provide Insights Into Anthracnose‐Resistance and Volatile Compound Biosynthesis Genes

Plant Biotechnology Journal, Volume 24, Issue 5, Page 3172-3188, May 2026.
ABSTRACT Mango (Mangifera indica) is one of the most popular fruits cultivated in tropical and subtropical regions of the world. The availability of reference genomes helps to identify the genetic basis of important traits. Here, we report assembled high‐quality chromosome‐level genomes for the Australian mango cultivar ‘Kensington Pride’ and M ...
Upendra Kumari Wijesundara, Agnelo Furtado, Ardashir Kharabian Masouleh, Natalie L. Dillon, Heather E. Smyth, Robert J. Henry   +5 more
wiley   +1 more source

Nonsense-mediated mRNA decay safeguards telomeres in pluripotent stem cells. [PDF]

Nat Cell Biol
Markiewicz-Potoczny M, Lee SY, Chatterjee S, Mabin JW, Zinsser A, Sandhu R, Tricola G, Hogg JR, Lazzerini Denchi E.   +8 more
europepmc   +1 more source

Multi‐Omics and Machine Learning‐Uncovered FLT1‐Mediated Epithelial‐Endothelial Crosstalk in Cellular Senescence Driving Clear Cell Renal Cell Carcinoma Malignancy

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
This study integrates multi‐omics data and machine learning to reveal FLT1 as a central mediator of epithelial‐endothelial crosstalk in clear cell renal cell carcinoma (ccRCC). We demonstrate that FLT1‐associated signaling promotes a senescence‐enriched tumor microenvironment, driving malignant progression. Spatial and single‐cell analyses confirm FLT1
Mouyuan Sun, Huchao Mao, Yaxian Luo, Mei Yang, Zhixu He, Shuangyang Li, Zhichao Liu, Lianjie Peng, Quanjie Zhang, Jingyu Zhang, Yan Zhang   +10 more
wiley   +1 more source

3,6'-Disinapoyl Sucrose from <i>Polygalae Radix</i> Exerts Anti-Aging Effects via Modification of Telomeres, SIRT1/p53/p21 Pathway, Oxidative Stress and Autophagy. [PDF]

Antioxidants (Basel)
Wang J, Jiang T, Chen S, Li Y, Li Q, Xiang L, Qi J.   +6 more
europepmc   +1 more source

The Regulation and Function of Hippo/YAP Pathway in Cancer

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Hippo/YAP pathway signaling plays critical roles in the progression of multiple cancer types. This review summarizes current knowledge of Hippo/YAP pathway regulation and function in cancer. We discuss the core components of the Hippo/YAP pathway; its crosstalk with other signaling pathways; regulation by non‐coding RNAs; roles of YAP signaling in ...
Chinmoy Ghosh, Ruchi Kakar, Seline Torkamboor, Yue Sun   +3 more
wiley   +1 more source