Results 21 to 30 of about 110,933 (294)

The JIL-1 kinase affects telomere expression in the different telomere domains of Drosophila. [PDF]

PLoS ONE, 2013
In Drosophila, the non-LTR retrotransposons HeT-A, TART and TAHRE build a head-to-tail array of repetitions that constitute the telomere domain by targeted transposition at the end of the chromosome whenever needed. As a consequence, Drosophila telomeres
Rute Silva-Sousa, Elena Casacuberta
doaj   +1 more source

Telomeric recombination induced by dysfunctional telomeres

Molecular Biology of the Cell, 2011
 Telomere maintenance is essential for cellular immortality, and most cancer cells maintain their telomeres through the enzyme telomerase. Telomeres and telomerase represent promising anticancer targets. However, 15% of cancer cells maintain their telomeres through alternative recombination-based mechanisms, and previous analyses showed that ...
Brault, Marie Eve, Autexier, Chantal
openaire   +2 more sources

Telomeres susceptibility to environmental arsenic exposure: Shortening or lengthening?

Frontiers in Public Health, 2023
Maintaining telomere length plays a crucial role in regulating cellular life span. Telomere lengthening or shortening is one of the important biomarkers which could predict the preceding or present diseases. Meanwhile, the impact of environmental arsenic
Kyi Mar Wai, Kyi Mar Wai, Thinzar Swe, Maw Thoe Myar, Cindy Rahman Aisyah, Thae Su Su Hninn   +5 more
doaj   +1 more source

Telomeric RNAs are essential to maintain telomeres [PDF]

Nature Communications, 2016
AbstractTelomeres are transcribed generating long non-coding RNAs known as TERRA. Deciphering the role of TERRA has been one of the unsolved issues of telomere biology in the past decade. This has been, in part, due to lack of knowledge on the TERRA loci, thus preventing functional genetic studies. Here, we describe that long non-coding RNAs with TERRA
Juan José Montero, Isabel López de Silanes, Osvaldo Graña, Maria A. Blasco   +3 more
openaire   +4 more sources

Association of telomere instability with senescence of porcine cells

BMC Cell Biology, 2012
Background Telomeres are essential for the maintenance of genomic stability, and telomere dysfunction leads to cellular senescence, carcinogenesis, aging, and age-related diseases in humans. Pigs have become increasingly important large animal models for
Ji Guangzhen, Liu Kai, Okuka Maja, Liu Na, Liu Lin   +4 more
doaj   +1 more source

Senescence, Telomere Shortening and Telomere Maintenance [PDF]

Cancer Biology & Therapy, 2002
No Abstract Available Commentary to: Title: Telomerase Protects Cancer-Prone Human Cells from Chromosomal Instability and Spontaneous Immortalization Authors: Lynne W. Elmore, Kristi C. Turner, Lauren S. Gollahon, Melissa R. Landon, Colleen K. Jackson-Cook and Shawn E.
openaire   +2 more sources

Telomere length comparison between oral cells and blood cells among neonates

The Turkish Journal of Pediatrics, 2019
Telomere length, measured from blood cells, is commonly used as the standard telomere length of the whole body. The relationship between blood telomere length and oral telomere length is still unclear, especially among neonates.
Mandar Bhattacharya, Pranami Bhaumik, Subrata Kumar-Dey   +2 more
doaj   +1 more source

Identification of Neuroblastoma Subgroups Based on Three-Dimensional Telomere Organization

Translational Oncology, 2016
Using 3D telomere quantitative fluorescence in situ hybridization, we determined the 3D telomere organization of 74 neuroblastoma tissue samples. Hierarchical cluster analysis of the measured telomere parameters identified three subgroups from our ...
Alexandra Kuzyk, John Gartner, Sabine Mai   +2 more
doaj   +1 more source

Why and when should organisms elongate their telomeres? Elaborations on the ‘excess resources elongation’ and ‘last resort elongation’ hypotheses

Ecology and Evolution, 2023
Telomere length and telomere shortening are thought to be critical cellular attributes and processes that are related to an individual's life span and fitness.
David Gómez‐Blanco, Michael Tobler, Dennis Hasselquist   +2 more
doaj   +1 more source

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source