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DNA methylation and telomere length in 2–5 year olds with intrauterine preeclampsia exposure: a P4 sub-study [PDF]
Clinical EpigeneticsPreeclampsia is a hypertensive disorder of pregnancy characterised by new onset hypertension at ≥ 20 weeks’ gestation accompanied by maternal organ dysfunction and/ or fetal compromise.
Jason P. Ross +10 more
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Open Biology, 2022 Telomeres are nucleoprotein structures that cap the ends of linear chromosomes. Telomeric DNA comprises terminal tracts of G-rich tandem repeats, which are inherently difficult for the replication machinery to navigate.
Robert Lu, Hilda A. Pickett
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EBioMedicine, 2021 Background: Telomere length (TL) is considered a biological marker of aging and may indicate age-related disease susceptibility. Adults and children show a fixed ranking and tracking of TL over time.
Dries S. Martens +5 more
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Progerin impairs 3D genome organization and induces fragile telomeres by limiting the dNTP pools
Scientific Reports, 2021 Chromatin organization within the nuclear volume is essential to regulate many aspects of its function and to safeguard its integrity. A key player in this spatial scattering of chromosomes is the nuclear envelope (NE).
Anna Kychygina +6 more
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Telomere Length Measurement by Molecular Combing
Frontiers in Cell and Developmental Biology, 2020 Telomeres are repetitive regions of DNA bound by specialized proteins at the termini of linear chromosomes that prevent the natural chromosome ends from being recognized as DNA double strand breaks.
Vivian F. S. Kahl +7 more
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Inheritance of telomere length in a bird. [PDF]
PLoS ONE, 2011 Telomere dynamics are intensively studied in human ageing research and epidemiology, with many correlations reported between telomere length and age-related diseases, cancer and death. While telomere length is influenced by environmental factors there is
Thorsten Horn +5 more
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Change in Leukocyte Telomere Length Predicts Mortality in Patients with Stable Coronary Heart Disease from the Heart and Soul Study. [PDF]
PLoS ONE, 2016 Short telomere length independently predicts mortality in patients with coronary heart disease. Whether 5-year change in telomere length predicts subsequent mortality in patients with coronary heart disease has not been evaluated.In a prospective cohort ...
Sarah E Goglin +5 more
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Frontiers in Oncology, 2022 The number of (TTAGGG)n repeats at the ends of chromosomes is highly variable between individual chromosomes, between different cells and between species. Progressive loss of telomere repeats limits the proliferation of pre-malignant human cells but also
Peter Lansdorp, Peter Lansdorp
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Telomeres susceptibility to environmental arsenic exposure: Shortening or lengthening?
Frontiers in Public Health, 2023 Maintaining telomere length plays a crucial role in regulating cellular life span. Telomere lengthening or shortening is one of the important biomarkers which could predict the preceding or present diseases. Meanwhile, the impact of environmental arsenic
Kyi Mar Wai +5 more
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Telomere length trajectory and its determinants in persons with coronary artery disease: longitudinal findings from the heart and soul study. [PDF]
PLoS ONE, 2010 Leukocyte telomere length, an emerging marker of biological age, has been shown to predict cardiovascular morbidity and mortality. However, the natural history of telomere length in patients with coronary artery disease has not been studied. We sought to
Ramin Farzaneh-Far +5 more
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