Results 1 to 10 of about 110,609 (302)

Newborn telomere length predicts later life telomere length: Tracking telomere length from birth to child- and adulthood [PDF]

EBioMedicine, 2021
Background: Telomere length (TL) is considered a biological marker of aging and may indicate age-related disease susceptibility. Adults and children show a fixed ranking and tracking of TL over time.
Dries S. Martens, Charlotte Van Der Stukken, Catherine Derom, Evert Thiery, Esmée M. Bijnens, Tim S. Nawrot   +5 more
doaj   +6 more sources

Telomere Length Regulation

Frontiers in Oncology, 2022
The number of (TTAGGG)n repeats at the ends of chromosomes is highly variable between individual chromosomes, between different cells and between species. Progressive loss of telomere repeats limits the proliferation of pre-malignant human cells but also
Peter Lansdorp, Peter Lansdorp
doaj   +3 more sources

Is telomere length socially patterned? Evidence from the West of Scotland Twenty-07 study [PDF]

, 2012
Lower socioeconomic status (SES) is strongly associated with an increased risk of morbidity and premature mortality, but it is not known if the same is true for telomere length, a marker often used to assess biological ageing. The West of Scotland Twenty-
A Aviv, A Aviv, A Benetos, A Steptoe, Alan McIntyre, AT Geronimus, AV Diez Roux, BM Unryn, CG Parks, CM Martin-Ruiz, D Janicki-Deverts, D Kuh, E Fernandez-Egea, ES Epel, F Maxwell, G Aubert, G. David Batty, GD Batty, Geoff Der, H Sies, J Adams, J Carrero, J Woo, JM Adams, John C. S. Breitner, K Lorimer, K Nordfjall, K Yaffe, KA Mather, KA Mather, L Kananen, LA Deroo, LF Cherkas, LF Cherkas, LF Hou, Liane M. McGlynn, M Benzeval, M Lee, M Walsh DT, MA Blasco, MG Marmot, Michael J. Green, Michaela Benzeval, NE Adler, NE Adler, P McLoone, Paul G. Shiels, PG Shiels, PG Shiels, PG Surtees, R Chan, RA Risques, RM Cawthon, RM Cawthon, S Macintyre, S Seaman, SE Harris, SE Harris, SM Lynch, T de Lange, T De Meyer, T von Zglinicki, T von Zglinicki, Tony Robertson, TS Nawrot, V Carstairs, W Chen, YL Zheng   +67 more
core   +25 more sources

Telomeric replication stress: the beginning and the end for alternative lengthening of telomeres cancers

Open Biology, 2022
Telomeres are nucleoprotein structures that cap the ends of linear chromosomes. Telomeric DNA comprises terminal tracts of G-rich tandem repeats, which are inherently difficult for the replication machinery to navigate.
Robert Lu, Hilda A. Pickett
doaj   +1 more source

The relationship of telomere length to baseline corticosterone levels in nestlings of an altricial passerine bird in natural populations [PDF]

, 2015
Indexación: Web of Science; Scopus.Background: Environmental stressors increase the secretion of glucocorticoids that in turn can shorten telomeres via oxidative damage.
Guerrero, C.J., Krause, J.S., Quirici, V., Vásquez, R.A., Wingfield, J.C.   +4 more
core   +6 more sources

Chronic psychosocial and financial burden accelerates 5-year telomere shortening: findings from the Coronary Artery Risk Development in Young Adults Study. [PDF]

, 2020
Leukocyte telomere length, a marker of immune system function, is sensitive to exposures such as psychosocial stressors and health-maintaining behaviors.
AJ Schuit, AK Damjanovic, Aric A. Prather, AT Geronimus, B Mezuk, Barbara Sternfeld, C Duggan, C Schaefer, CG Parks, CK Enders, CM Aldwin, DS Lauderdale, E Puterman, E Puterman, E Puterman, E Puterman, E Puterman, E Sahin, EH Blackburn, Eli Puterman, Elissa S. Epel, ES Epel, ES Epel, ES Epel, GD Friedman, GE Miller, GL Schlomer, H Ma, IM Wentzensen, J Campisi, J Deelen, J Humphreys, J Lin, J Svensson, J Zhao, JE Verhoeven, JE Verhoeven, JJW Liu, JP Gouin, JR Piazza, Jue Lin, K Ahola, K Litzelman, L Ala-Mursula, L Bendix, L Rode, L Rode, LI Pearlin, M Booth, M Hamer, M Jaskelioff, M Kimura, ME Glickman, MF Scheier, MH Schafer, Nancy Adler, OT Njajou, PC Haycock, PG Surtees, RM Cawthon, RM Cawthon, S Cohen, S Cohen, S Cohen, S Cohen, S Jodczyk, S Richardson, S Yusuf, SE Taylor, SE Taylor, SL Bakaysa, ST Charles, T Steenstrup, TC Adam, TE Seeman, Tomás Cabeza de Baca, U Svenson, V Codd, W Chen, W Poortinga, Y Zhan   +80 more
core   +1 more source

Progerin impairs 3D genome organization and induces fragile telomeres by limiting the dNTP pools

Scientific Reports, 2021
Chromatin organization within the nuclear volume is essential to regulate many aspects of its function and to safeguard its integrity. A key player in this spatial scattering of chromosomes is the nuclear envelope (NE).
Anna Kychygina, Marina Dall’Osto, Joshua A. M. Allen, Jean-Charles Cadoret, Vincent Piras, Hilda A. Pickett, Laure Crabbe   +6 more
doaj   +1 more source

Telomere Length Measurement by Molecular Combing

Frontiers in Cell and Developmental Biology, 2020
Telomeres are repetitive regions of DNA bound by specialized proteins at the termini of linear chromosomes that prevent the natural chromosome ends from being recognized as DNA double strand breaks.
Vivian F. S. Kahl, Joshua A. M. Allen, Christopher B. Nelson, Alexander P. Sobinoff, Michael Lee, Tatjana Kilo, Raja S. Vasireddy, Hilda A. Pickett   +7 more
doaj   +1 more source

Inheritance of telomere length in a bird. [PDF]

PLoS ONE, 2011
Telomere dynamics are intensively studied in human ageing research and epidemiology, with many correlations reported between telomere length and age-related diseases, cancer and death. While telomere length is influenced by environmental factors there is
Thorsten Horn, Bruce C Robertson, Margaret Will, Daryl K Eason, Graeme P Elliott, Neil J Gemmell   +5 more
doaj   +1 more source

Change in Leukocyte Telomere Length Predicts Mortality in Patients with Stable Coronary Heart Disease from the Heart and Soul Study. [PDF]

PLoS ONE, 2016
Short telomere length independently predicts mortality in patients with coronary heart disease. Whether 5-year change in telomere length predicts subsequent mortality in patients with coronary heart disease has not been evaluated.In a prospective cohort ...
Sarah E Goglin, Ramin Farzaneh-Far, Elissa S Epel, Jue Lin, Elizabeth H Blackburn, Mary A Whooley   +5 more
doaj   +1 more source