Results 11 to 20 of about 57,502 (259)
Telomere Length and Male Fertility [PDF]
International Journal of Molecular Sciences, 2021 Over the past decade, telomeres have attracted increasing attention due to the role they play in human fertility. However, conflicting results have been reported on the possible association between sperm telomere length (STL) and leukocyte telomere length (LTL) and the quality of the sperm parameters.
Gentiluomo M. +8 more
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Telomere length homeostasis [PDF]
Chromosoma, 2006 The physical ends of chromosomes, known as telomeres, protect chromosome ends from nucleolytic degradation and DNA repair activities. Conventional DNA replication enzymes lack the ability to fully replicate telomere ends. In addition, nucleolytic activities contribute to telomere erosion.
Hug, Nele, Lingner, Joachim
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Telomeres and Telomere Length: A General Overview [PDF]
Cancers, 2020 Telomeres are highly conserved tandem nucleotide repeats that include proximal double-stranded and distal single-stranded regions that in complex with shelterin proteins afford protection at chromosomal ends to maintain genomic integrity. Due to the inherent limitations of DNA replication and telomerase suppression in most somatic cells, telomeres ...
Nalini Srinivas +2 more
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Nursing Research, 2014 BackgroundThe exciting discovery that telomere shortening is associated with many health conditions and that telomere lengths can be altered in response to social and environmental exposures has underscored the need for methods to accurately and consistently quantify telomere length.ObjectivesThe purpose of this article is to provide a comprehensive ...
Montpetit, Alison J +10 more
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A mechanism for telomere-specific telomere length regulation. [PDF]
Nucleic Acids ResSUMMARY Telomere length is a critical determinant of telomere function and hence chromosome stability. Critically short telomeres induce cellular senescence and division arrest, which eventually may lead to devastating age-related degenerative diseases. Conversely, maintenance of telomere length is a hallmark of cancer.
Teplitz GM +8 more
europepmc +4 more sources
Telomeric RNA Expression: Length Matters [PDF]
Frontiers in Oncology, 2013 A commentary on TERRA expression levels do not correlate with telomere length and radiation sensitivity in human cancer cell ...
Van Beneden, Amandine +2 more
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Telomere length and reproductive aging [PDF]
Human Reproduction, 2009 Rate of reproductive aging may be related to rate of biological aging. Thus, indicators of aging, such as short telomere length, may be more frequent in women with a history suggestive of premature reproductive senescence.Telomere-specific quantitative PCR was used to assess telomere length in two groups of women with evidence of reproductive aging: (i)
Hanna, Courtney W. +5 more
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Telomere Length and Bipolar Disorder [PDF]
Neuropsychopharmacology, 2017 AbstractVariation in telomere length is heritable and is currently considered a promising biomarker of susceptibility for neuropsychiatric disorders, particularly because of its association with memory function and hippocampal morphology. Here, we investigate telomere length in connection to familial risk and disease expression in bipolar disorder (BD).
Timothy R Powell +3 more
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Nature Communications, 2019 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Robert Lu +9 more
doaj +1 more source
EMBO Molecular Medicine, 2022 In some types of cancer, telomere length is maintained by the alternative lengthening of telomeres (ALT) mechanism. In many ALT cancers, the α‐thalassemia/mental retardation syndrome X‐linked (ATRX) gene is mutated leading to the conclusion that the ATRX
Alexandre de Nonneville +15 more
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