Results 11 to 20 of about 110,609 (302)

Telomere length heterogeneity in placenta revealed with high-resolution telomere length analysis [PDF]

Placenta, 2017
Introduction Telomeres, are composed of tandem repeat sequences located at the ends of chromosomes and are required to maintain genomic stability. Telomeres can become shorter due to cell division and specific lifestyle factors.
Baird, Duncan M., Garcia Martin, Isabel, Grimstead, Julia W., Janssen, A.B., John, Rosalind M., Jones, Robert, Penketh, Richard J. A.   +6 more
core   +11 more sources

Telomere Length and Male Fertility [PDF]

International Journal of Molecular Sciences, 2021
Over the past decade, telomeres have attracted increasing attention due to the role they play in human fertility. However, conflicting results have been reported on the possible association between sperm telomere length (STL) and leukocyte telomere length (LTL) and the quality of the sperm parameters.
Gentiluomo M., Luddi A., Cingolani A., Fornili M., Governini L., Lucenteforte E., Baglietto L., Piomboni P., Campa D.   +8 more
openaire   +4 more sources

Telomere length homeostasis [PDF]

Chromosoma, 2006
The physical ends of chromosomes, known as telomeres, protect chromosome ends from nucleolytic degradation and DNA repair activities. Conventional DNA replication enzymes lack the ability to fully replicate telomere ends. In addition, nucleolytic activities contribute to telomere erosion.
Hug, Nele, Lingner, Joachim
openaire   +3 more sources

Telomeres and Telomere Length: A General Overview [PDF]

Cancers, 2020
Telomeres are highly conserved tandem nucleotide repeats that include proximal double-stranded and distal single-stranded regions that in complex with shelterin proteins afford protection at chromosomal ends to maintain genomic integrity. Due to the inherent limitations of DNA replication and telomerase suppression in most somatic cells, telomeres ...
Nalini Srinivas, Sivaramakrishna Rachakonda, Rajiv Kumar   +2 more
openaire   +2 more sources

Telomere Length [PDF]

Nursing Research, 2014
BackgroundThe exciting discovery that telomere shortening is associated with many health conditions and that telomere lengths can be altered in response to social and environmental exposures has underscored the need for methods to accurately and consistently quantify telomere length.ObjectivesThe purpose of this article is to provide a comprehensive ...
Montpetit, Alison J, Alhareeri, Areej A, Montpetit, Marty, Starkweather, Angela R, Elmore, Lynne W, Filler, Kristin, Mohanraj, Lathika, Burton, Candace W, Menzies, Victoria S, Lyon, Debra E, Jackson-Cook, Colleen K   +10 more
openaire   +5 more sources

Telomeric RNA Expression: Length Matters [PDF]

Frontiers in Oncology, 2013
A commentary on TERRA expression levels do not correlate with telomere length and radiation sensitivity in human cancer cell ...
Van Beneden, Amandine, Arnoult, Nausica, Decottignies, Anabelle   +2 more
openaire   +4 more sources

Telomeres susceptibility to environmental arsenic exposure: Shortening or lengthening?

Frontiers in Public Health, 2023
Maintaining telomere length plays a crucial role in regulating cellular life span. Telomere lengthening or shortening is one of the important biomarkers which could predict the preceding or present diseases. Meanwhile, the impact of environmental arsenic
Kyi Mar Wai, Kyi Mar Wai, Thinzar Swe, Maw Thoe Myar, Cindy Rahman Aisyah, Thae Su Su Hninn   +5 more
doaj   +1 more source

A mechanism for telomere-specific telomere length regulation. [PDF]

Nucleic Acids Res
SUMMARY Telomere length is a critical determinant of telomere function and hence chromosome stability. Critically short telomeres induce cellular senescence and division arrest, which eventually may lead to devastating age-related degenerative diseases. Conversely, maintenance of telomere length is a hallmark of cancer.
Teplitz GM, Pasquier E, Bonnell E, De Laurentiis E, Bartle L, Lucier JF, St-Laurent G, Dawson DS, Wellinger RJ.   +8 more
europepmc   +4 more sources

Telomere length and reproductive aging [PDF]

Human Reproduction, 2009
Rate of reproductive aging may be related to rate of biological aging. Thus, indicators of aging, such as short telomere length, may be more frequent in women with a history suggestive of premature reproductive senescence.Telomere-specific quantitative PCR was used to assess telomere length in two groups of women with evidence of reproductive aging: (i)
Hanna, Courtney W., Bretherick, Karla L., Gair, Jane L., Fluker, Margo R., Stephenson, Mary D., Robinson, Wendy P.   +5 more
openaire   +2 more sources

Telomere Length and Bipolar Disorder [PDF]

Neuropsychopharmacology, 2017
AbstractVariation in telomere length is heritable and is currently considered a promising biomarker of susceptibility for neuropsychiatric disorders, particularly because of its association with memory function and hippocampal morphology. Here, we investigate telomere length in connection to familial risk and disease expression in bipolar disorder (BD).
Timothy R Powell, Danai Dima, Sophia Frangou, Gerome Breen   +3 more
openaire   +7 more sources