Results 21 to 30 of about 110,609 (302)

Measuring vertebrate telomeres: applications and limitations [PDF]

, 2004
Telomeres are short tandem repeated sequences of DNA found at the ends of eukaryotic chromosomes that function in stabilizing chromosomal end integrity.
Allsopp RC, Barja G, Benetos A, Broccoli D, Chang E, Charnov E, Friedrich U, Gemmell NJ, Girondot M, Grant JD, Harley CB, IUCN, Jeanclos E, Kern S, Lambertsen RH, Meyne J, Miyashita N, Ogburn CE, Olsen E, Prowse KR, Rose MR, Slagboom PE, Stearns SC, Stearns SC, Turker M, Vaziri H, Watson J, Zeichner SL   +27 more
core   +1 more source

Oxidative stress, telomeres and cellular senescence: What non-drug interventions might break the link? [PDF]

, 2020
Telomeres are higher order structures that cap and protect chromosome ends. Telomeric DNA naturally shortens during somatic cell division and as a result of oxidative stress.
Erusalimsky, Jorge
core   +1 more source

Telomere length trajectory and its determinants in persons with coronary artery disease: longitudinal findings from the heart and soul study. [PDF]

PLoS ONE, 2010
Leukocyte telomere length, an emerging marker of biological age, has been shown to predict cardiovascular morbidity and mortality. However, the natural history of telomere length in patients with coronary artery disease has not been studied. We sought to
Ramin Farzaneh-Far, Jue Lin, Elissa Epel, Kyle Lapham, Elizabeth Blackburn, Mary A Whooley   +5 more
doaj   +1 more source

Telomere dysfunction accurately predicts clinical outcome in chronic lymphocytic leukaemia, even in patients with early stage disease [PDF]

, 2014
© 2014 John Wiley & Sons Ltd. Defining the prognosis of individual cancer sufferers remains a significant clinical challenge. Here we assessed the ability of high-resolution single telomere length analysis (STELA), combined with an experimentally ...
Allan, James M., Allsup, David J., Bailey, James, Baird, Duncan M., Britt-Compton, Bethan, Cawkwell, Lynn, Fegan, Chris, Grimstead, Julia W., Heppel, Nicole H., Hills, Robert, Jones, Rhiannon E., Lin, Thet Thet, Norris, Kevin, Pepper, Chris, Pratt, Guy   +14 more
core   +1 more source

Author Correction: The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

Nature Communications, 2019
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Robert Lu, Julienne J. O’Rourke, Alexander P. Sobinoff, Joshua A. M. Allen, Christopher B. Nelson, Christopher G. Tomlinson, Michael Lee, Roger R. Reddel, Andrew J. Deans, Hilda A. Pickett   +9 more
doaj   +1 more source

Genetic regulation of newborn telomere length is mediated and modified by DNA methylation

Frontiers in Genetics, 2022
Telomere length at birth determines later life telomere length and potentially predicts ageing-related diseases. However, the genetic and epigenetic settings of telomere length in newborns have not been analyzed.
Congrong Wang, Rossella Alfano, Brigitte Reimann, Janneke Hogervorst, Mariona Bustamante, Mariona Bustamante, Mariona Bustamante, Mariona Bustamante, Immaculata De Vivo, Immaculata De Vivo, Michelle Plusquin, Tim S. Nawrot, Tim S. Nawrot, Dries S. Martens   +13 more
doaj   +1 more source

Alcohol consumption and leukocyte telomere length. [PDF]

, 2019
The relationship between alcohol consumption and mortality generally exhibits a U-shaped curve. The longevity observed with moderate alcohol consumption may be explained by other confounding factors, and, if such a relationship is present, the mechanism ...
Dixit, Shalini, Fitzpatrick, Annette L, Heckbert, Susan R, Leung, Cindy, Lin, Jue, Marcus, Gregory M, Mukamal, Kenneth J, Roberts, Jason D, Vittinghoff, Eric, Whooley, Mary A   +9 more
core   +2 more sources

Shorter Leukocyte Telomere Length in Relation to Presumed Nonalcoholic Fatty Liver Disease in Mexican-American Men in NHANES 1999-2002. [PDF]

, 2017
Leukocyte telomere length is shorter in response to chronic disease processes associated with inflammation such as diabetes mellitus and coronary artery disease.
Epel, Elissa, Rehkopf, David, Rosenthal, Philip, Wojcicki, Janet M   +3 more
core   +2 more sources

The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

Nature Communications, 2019
ALT telomeres experience DNA damage that may drive recombination-based telomere elongation. Here, the authors reveal that FANCM plays a critical role in the suppression of ALT activity through its interaction with the BTR (BLM-TOP3A-RMI) complex.
Robert Lu, Julienne J. O’Rourke, Alexander P. Sobinoff, Joshua A. M. Allen, Christopher B. Nelson, Christopher G. Tomlinson, Michael Lee, Roger R. Reddel, Andrew J. Deans, Hilda A. Pickett   +9 more
doaj   +1 more source

Circulating leukocyte telomere length is highly heritable among families of Arab descent [PDF]

, 2012
Background Telomere length, an indicator of ageing and longevity, has been correlated with several biomarkers of cardiometabolic disease in both Arab children and adults.
AS Al-Rethaiaa, Assim A Alfadda, C Bischoff, ES Epel, George P Chrousos, Greg C Gibson, J Lin, K Nordfjall, KA Mather, Khalid M Alkharfy, L Kazubowska, LS Wong, Majed S Alokail, MM Al-Nozha, Nasser M Al-Daghri, NM Al-Daghri, NM Al-Daghri, NM Al-Daghri, NM Al-Daghri, NM Al-Daghri, NM Al-Daghri, NM Bawazeer, O Al-Attas, Omar S Al-Attas, OS Al-Attas, OT Njajou, Philip McTernan, RM Cawthon, Shaun B Sabico, TJ Cole, WS Browner   +30 more
core   +3 more sources