Effect of telomere length on telomeric gene expression [PDF]
Nucleic Acids Research, 1996 Telomeres gradually shorten as human somatic cells divide and a correlation has been observed between the average telomere length and cell senescence. It has been proposed that the genes responsible for cell senescence are located near the telomere and are activated when telomere length reaches a critical point.
C N, Sprung, L, Sabatier, J P, Murnane
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EMBO Molecular Medicine, 2022 In some types of cancer, telomere length is maintained by the alternative lengthening of telomeres (ALT) mechanism. In many ALT cancers, the α‐thalassemia/mental retardation syndrome X‐linked (ATRX) gene is mutated leading to the conclusion that the ATRX
Alexandre de Nonneville +15 more
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Impartial comparative analysis of measurement of leukocyte telomere length/DNA content by Southern blots and qPCR. [PDF]
, 2011 Telomere length/DNA content has been measured in epidemiological/clinical settings with the goal of testing a host of hypotheses related to the biology of human aging, but often the conclusions of these studies have been inconsistent.
Aviv, Abraham +5 more
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Age and heat stress as determinants of telomere length in a long-lived fish, the Siberian Sturgeon [PDF]
, 2016 Telomeres shorten at each cell division due to the end-replication problem but also in response to oxidative stress. Consequently, telomeres shorten with age in many endotherms, and this shortening is accelerated under stressful environmental conditions.
Angelier, Frédéric +3 more
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Telomere length comparison between oral cells and blood cells among neonates
The Turkish Journal of Pediatrics, 2019 Telomere length, measured from blood cells, is commonly used as the standard telomere length of the whole body. The relationship between blood telomere length and oral telomere length is still unclear, especially among neonates.
Mandar Bhattacharya +2 more
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Decreasing initial telomere length in humans intergenerationally understates age-associated telomere shortening [PDF]
, 2015 Telomere length shortens with aging, and short telomeres have been linked to a wide variety of pathologies. Previous studies suggested a discrepancy in age-associated telomere shortening rate estimated by cross-sectional studies versus the rate measured ...
Batten, Kimberly +10 more
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Telomere length in myelodysplastic syndromes [PDF]
American Journal of Hematology, 1997 We have studied telomere length in the bone marrow cells or the granulocyte and lymphocyte cell fractions of 54 patients with myelodysplastic syndromes (MDS) by Southern blot hybridization using the (TTAGGG)4 probe. The average telomere length expressed as the peak telomere repeat array (TRA) in the peripheral blood, or bone marrow samples obtained ...
Boultwood, J +8 more
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Links between parental life histories of wild salmon and the telomere lengths of their offspring [PDF]
, 2017 The importance of parental contributions to offspring development and subsequent performance is self-evident at a genomic level; however, parents can also affect offspring fitness by indirect genetic and environmental routes.
Armstrong, John D. +7 more
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Shorter juvenile telomere length is associated with higher survival to spawning in migratory Atlantic salmon [PDF]
, 2017 The risk of mortality associated with a long-distance migration will depend on an animal's physiological state, as well as the prevailing ecological conditions.
Armstrong, John D. +6 more
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Telomere length and incident atrial fibrillation - data of the PREVEND cohort.
PLoS ONE, 2017 BackgroundThe incidence of atrial fibrillation (AF) increases with age. Telomere length is considered a marker of biological ageing. We investigated the association between leukocyte telomere length and incident AF in the Dutch Prevention of Renal and ...
Joylene E Siland +4 more
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