Results 41 to 50 of about 57,502 (259)
Telomere length in Trypanosoma brucei [PDF]
Experimental Parasitology, 2008 Trypanosoma brucei thwarts the host immune response by replacing its variant surface glycoprotein (VSG). The actively transcribed VSG is located in one of approximately 20 telomeric expression sites (ES). Antigenic variation can occur by transcriptional switching, reciprocal translocations, or duplicative gene conversion events among ES or with the ...
Oliver, Dreesen, George A M, Cross
openaire +2 more sources
Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors
Advanced Science, EarlyView.Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen +4 more
wiley +1 more source
NONO, SFPQ, and PSPC1 promote telomerase recruitment to the telomere
Nature CommunicationsTelomerase is a ribonucleoprotein enzyme that maintains telomeric repeats on chromosome ends in continuously dividing cells. Telomere maintenance via telomerase is dependent on the correct assembly of the enzyme complex, complex stabilization by ...
Alexander P. Sobinoff +9 more
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Frontiers in Nutrition, 2022 BackgroundDietary habits and dietary intake affect telomere length, a reliable marker of biological aging and a predictor of chronic disease. Riboflavin (RF) is known as a water-soluble antioxidant vitamin, but its role in telomere length maintenance has
Weihua Chen +8 more
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NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease
Advanced Science, EarlyView.NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang +18 more
wiley +1 more source
Association between lipoproteins and telomere length in US adults: data from the NHANES 1999–2002
Lipids in Health and Disease, 2019 Background Evidence regarding the correlation between lipoproteins and telomere length in US adults is limited. We aimed to investigate whether lipoproteins was associated with telomere length using US National Health and Nutrition Examination Survey ...
Yun-Fen Chen +3 more
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Factors related to telomere length [PDF]
Brain, Behavior, and Immunity, 2016 We appreciate the comments by Tasdemir and Oz on our recent paper in Brain, Behavior & Immunity (Prather et al., 2015). The question of what is “causing bad sleep” is certainly an important one, and the authors list some of the key culprits (e.g., excess alcohol consumption, caffeine at night, and menopausal symptoms).
Aric A, Prather +2 more
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DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss
Advanced Science, EarlyView.Senescent bone marrow stromal cells accumulate in the aging bone microenvironment, promoting bone degeneration. DEL‐1, an endogenous secreted protein, acts as a natural senolytic that selectively eliminates these cells. By engaging a β3 integrin/CD73/adenosine/p38 MAPK/BCL‐2 pathway, DEL‐1 counters aging‐related bone loss, revealing promising ...
Jong‐Hyung Lim +11 more
wiley +1 more source
Correlation of telomere length in brain tissue with peripheral tissues in living human subjects
Frontiers in Molecular NeuroscienceTelomeres are important to chromosomal stability, and changes in their length correlate with disease, potentially relevant to brain disorders. Assessing telomere length in human brain is invasive, but whether peripheral tissue telomere length correlates ...
Annemarie J. Carver +26 more
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Advanced Science, EarlyView.This study identifies a new viral mechanism by a viral protein σ3 that functions as a vTR to suppress NF‐κB gene expression via its direct interaction with the host helicase DHX9. Through their interaction, σ3 not only impairs the initial recruitment of Pol II but also affects Pol II pause‐release and ultimately suppresses NF‐κB gene expression ...
Xueyang Pang +12 more
wiley +1 more source