Results 11 to 20 of about 45,980 (243)
Telomeric RNAs are essential to maintain telomeres [PDF]
Nature Communications, 2016 The telomeric long-non coding RNA, TERRA, has been proposed in the past to modulate different telomeric functions based on in vitrostudies. Here the authors show, using a genetic deletion approach, that TERRA is transcribed from the 20q subtelomere and ...
Juan José Montero +3 more
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The human telomeric proteome during telomere replication [PDF]
Nucleic Acids Research, 2020 Abstract Telomere shortening can cause detrimental diseases and contribute to aging. It occurs due to the end replication problem in cells lacking telomerase. Furthermore, recent studies revealed that telomere shortening can be attributed to difficulties of the semi-conservative DNA replication machinery to replicate the bulk of ...
Chih-Yi Gabriela Lin +5 more
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EMBO reports, 2002 Telomeres are protein–DNA complexes that cap chromosome ends and protect them from being recognized and processed as DNA breaks. Loss of capping function results in genetic instability and loss of cellular viability. The emerging view is that maintenance of an appropriate telomere structure is essential for function. Structural information on telomeric
Daniela, Rhodes +4 more
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A ‘higher order’ of telomere regulation: telomere heterochromatin and telomeric RNAs [PDF]
The EMBO Journal, 2009 Protection of chromosome ends from DNA repair and degradation activities is mediated by specialized protein complexes bound to telomere repeats. Recently, it has become apparent that epigenetic regulation of the telomeric chromatin template critically impacts on telomere function and telomere-length homeostasis from yeast to man.
SCHOEFTNER, Stefan, Blasco Maria, A.
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Retrotransposons and Telomeres
Biochemistry (Moscow), 2023 Abstract Transposable elements (TEs) comprise a significant part of eukaryotic genomes being a major source of genome instability and mutagenesis. Cellular defense systems suppress the TE expansion at all stages of their life cycle. Piwi proteins and Piwi-interacting RNAs (piRNAs) are key elements of the anti-transposon
Alla I, Kalmykova, Olesya A, Sokolova
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Telomeres and Telomere Length: A General Overview [PDF]
Cancers, 2020 Telomeres are highly conserved tandem nucleotide repeats that include proximal double-stranded and distal single-stranded regions that in complex with shelterin proteins afford protection at chromosomal ends to maintain genomic integrity. Due to the inherent limitations of DNA replication and telomerase suppression in most somatic cells, telomeres ...
Nalini Srinivas +2 more
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F1000Research, 2016 Telomeres, the protective ends of linear chromosomes, shorten throughout an individual’s lifetime. Telomere shortening is a hallmark of molecular aging and is associated with premature appearance of diseases associated with aging.
Christian Bär, Maria A. Blasco
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Mice with hyper-long telomeres show less metabolic aging and longer lifespans
Nature Communications, 2019 Telomere shortening is associated with aging. Here the authors analyze mice with hyperlong telomeres and demonstrate that longer telomeres than normal have beneficial effects such as delayed metabolic aging, increased longevity and less incidence of ...
Miguel A. Muñoz-Lorente +2 more
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The pif1 helicase, a negative regulator of telomerase, acts preferentially at long telomeres. [PDF]
PLoS Genetics, 2015 Telomerase, the enzyme that maintains telomeres, preferentially lengthens short telomeres. The S. cerevisiae Pif1 DNA helicase inhibits both telomerase-mediated telomere lengthening and de novo telomere addition at double strand breaks (DSB).
Jane A Phillips +3 more
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XPF activates break-induced telomere synthesis
Nature Communications, 2022 Here the authors show TERRA R-loops recruit the endonuclease XPF to telomeres, leading to DNA double-strand breaks to activate break-induced telomere synthesis at telomeres that utilize the alternative lengthening of telomeres (ALT) pathway to extend ...
Chia-Yu Guh +15 more
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