Results 11 to 20 of about 68,105 (246)
Nature Communications, 2016 Telomere shortening has been linked to some aspects of organismal ageing. Here the authors create chimaeric mice that contain a mix of cells with normal or unnaturally long telomeres, and show chimaeric mice are protected from some forms of ageing ...
Elisa Varela +4 more
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The pif1 helicase, a negative regulator of telomerase, acts preferentially at long telomeres. [PDF]
PLoS Genetics, 2015 Telomerase, the enzyme that maintains telomeres, preferentially lengthens short telomeres. The S. cerevisiae Pif1 DNA helicase inhibits both telomerase-mediated telomere lengthening and de novo telomere addition at double strand breaks (DSB).
Jane A Phillips +3 more
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XPF activates break-induced telomere synthesis
Nature Communications, 2022 Here the authors show TERRA R-loops recruit the endonuclease XPF to telomeres, leading to DNA double-strand breaks to activate break-induced telomere synthesis at telomeres that utilize the alternative lengthening of telomeres (ALT) pathway to extend ...
Chia-Yu Guh +15 more
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The house mouse maintains constant telomere length throughout life [PDF]
Nucleic Acids ResRiham Smoom +3 more
europepmc +3 more sources
Haematologica, 2015 Aplastic anemia is a rare but life-threatening disorder characterized by cytopenia in at least two of the three blood lineages. A frequent feature of patients with aplastic anemia is that they have shorter telomeres than those of age-matched controls ...
Christian Bär +3 more
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Multiple cancer pathways regulate telomere protection
EMBO Molecular Medicine, 2019 Telomeres are considered as universal anti‐cancer targets, as telomere maintenance is essential to sustain indefinite cancer growth. Mutations in telomerase, the enzyme that maintains telomeres, are among the most frequently found in cancer. In addition,
Leire Bejarano +9 more
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EMBO Molecular Medicine, 2012 A major goal in aging research is to improve health during aging. In the case of mice, genetic manipulations that shorten or lengthen telomeres result, respectively, in decreased or increased longevity.
Bruno Bernardes de Jesus +6 more
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The Rate of Increase of Short Telomeres Predicts Longevity in Mammals
Cell Reports, 2012 Aberrantly short telomeres result in decreased longevity in both humans and mice with defective telomere maintenance. Normal populations of humans and mice present high interindividual variation in telomere length, but it is unknown whether this is ...
Elsa Vera +4 more
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Telomeric RNAs are essential to maintain telomeres
Nature Communications, 2016 The telomeric long-non coding RNA, TERRA, has been proposed in the past to modulate different telomeric functions based on in vitrostudies. Here the authors show, using a genetic deletion approach, that TERRA is transcribed from the 20q subtelomere and ...
Juan José Montero +3 more
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iScience, 2019 Summary: Telomeres are considered potential anti-cancer targets. Most studies have focused on telomerase inhibition, but this strategy has largely failed in clinical trials.
Leire Bejarano +5 more
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