Results 211 to 220 of about 68,105 (246)

The causative role of amyloidosis in the cardiac complications of Alzheimer's disease: a comprehensive systematic review

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker, Andrew F. James, Svetlana Mastitskaya   +2 more
wiley   +1 more source

CHAMP1 complex promotes heterochromatin assembly and reduces replication stress. [PDF]

Proc Natl Acad Sci U S A
Li F, Elbakry A, Zhou FY, Zhang T, Ravindranathan R, Nguyen H, Syed A, Sun L, Mukkavalli S, Greenberg RA, D'Andrea AD.   +10 more
europepmc   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Telomeric DNA damage landscapes distinguish oxidative from inflammatory cellular stress. [PDF]

Nucleic Acids Res
Fleming AM, Burrows CJ.
europepmc   +1 more source

GWAS‐assisted genomic selection for achieving high‐precision early sex prediction in Populus deltoides

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Poplar (Populus spp.) breeding programs increasingly prioritize the development of male varieties due to the environmental issues caused by female catkins. Therefore, there is an urgent need for a reliable technique for early sex identification in Populus.
Xinglu Zhou, Min Zhang, Lei Zhang, Jianjun Hu   +3 more
wiley   +1 more source

Neurogenesis and the Epigenetic Landscape: Role of Histone Modifications and Chromatin Remodeling

Brain and Behavior, Volume 16, Issue 2, February 2026.
Histone methylation and acetylation modulate gene expression by inducing chromatin condensation or relaxation, which in turn regulates transcriptional activity and impacts neurogenesis. ABSTRACT Aims The purpose of this review is to examine how epigenetic regulation particularly chromatin modification and histone methylation controls gene expression ...
Degisew Yinur Mengistu, Biniam Moges Eskeziyaw   +1 more
wiley   +1 more source

Human-length Telomeres Limit Regeneration of Liver Epithelial Cells in Mice. [PDF]

Cell Mol Gastroenterol Hepatol
Hu MY, Rowe M, Tigue M, Reizel Y, Smoom R, Tzfati Y, Kaestner KH.   +6 more
europepmc   +1 more source

Engineering Immortalized Bovine Granulosa Cells Using a Triple‐Gene Approach: Mutant CDK4, Cyclin D1, and TERT

Cell Biology International, Volume 50, Issue 2, February 2026.
ABSTRACT Advancing reproductive technologies in livestock is essential to improve both productivity and genetic potential of cattle. Despite this importance, application of reproductive biotechnologies in cattle breeding remains limited. Bovine granulosa cells (bGCs), which are key components of the ovarian follicle, are critical in female reproduction
Lanlan Bai, Minami Takahashi, Jin Kobayashi, Takahiro Eitsuka, Himari Matsusaka, Taku Ozaki, Eriko Sugano, Hiroshi Tomita, Yuan Xu, Kazuhiro Kawamura, Kiyotaka Nakagawa, Tohru Kiyono, Tomokazu Fukuda   +12 more
wiley   +1 more source

Differential splice isoforms of mouse CDK2 play functionally redundant roles during mitotic and meiotic division. [PDF]

J Cell Sci
Palmer N, Kalem-Yapar NE, Hultén H, Keles U, Talib SZA, Ow JR, Tabaglio T, Goh CMF, Zhao LN, Guccione E, Liu K, Kaldis P.   +11 more
europepmc   +1 more source

New cell lines expanding the diversity of Ewing sarcoma models

International Journal of Cancer, Volume 158, Issue 3, Page 642-655, 1 February 2026.
What's new? A chromosomal translocation between the EWSR1 and ETS genes is the key oncogenic driver in Ewing sarcoma. EWSR1::FLI1, the most frequent fusion, is subdivided into different fusion types with unclear prognostic relevance. Here, the authors describe the establishment and characterization of four new, intrinsically immortal, patient‐derived ...
Maximilian Kerkhoff, Christiane Schaefer, Wilhelm G. Dirks, Dawid Krzeciesa, Maximilian Bretschneider, Pauline R. Plaumann, Wiebke K. Guder, Arne Streitbürger, Sonja Herter, Heike Peterziel, Ina Oehme, Felina Zahnow, Thomas G. P. Grünewald, Uta Dirksen   +13 more
wiley   +1 more source