Results 1 to 10 of about 126,726 (160)

Two co-inherited SNPs of the telomerase reverse transcriptase (TERT) gene are associated with Iraqi patients with lung cancer [PDF]

Journal of Medical Biochemistry, 2023
Background: The telomerase reverse transcriptase (TERT) gene is essential polymorphic loci linked to most malignant tumors. This study assessed the association between the TERT gene and non-small cell lung carcinoma (NSCLC) in Iraq.
Lawi Zahraa K., Alkhammas Ahmed H., Elerouri Malek, Ben Amara Ibtissem, Al-Shuhaib Mohammed Baqur S.   +4 more
doaj   +1 more source

Clinicopathological Significance of BRAF (V600E), NRAS (Q61K) and TERT (C228T, C250T and SNP Rs2853669) Mutations in Bulgarian Papillary Thyroid Carcinoma Patients

Acta Medica Bulgarica, 2021
Introduction: Thyroid carcinoma is the most common endocrine cancer. Some somatic mutations in genes (BRAF, NRAS and TERT) involved in key signaling pathways and genome stability have been recently identified to play an important role in its development.
Vidinov K., Dodova R., Mitev P., Mitkova A., Dimitrova I., Shinkov A., Ivanova R., Mitev V., Kaneva R.   +8 more
doaj   +1 more source

BRAF, NRAS, KIT, TERT, GNAQ/GNA11 Mutation Profile and Histomorphological Analysis of Anorectal Melanomas: A Clinicopathologic Study

Türk Patoloji Dergisi, 2023
Objective: Primary anorectal melanomas (AMs) are uncommon neoplasms with aggressive behavior. Molecular profile and clinicopathologic features of AMs are still not well established.
Orhun Cig TASKIN, Sule OZTURK SARI, Ismail YILMAZ, Ozge HURDOGAN, Metin KESKIN, Nesimi BUYUKBABANI, Mine GULLUOGLU   +6 more
doaj   +1 more source

Immunohistochemical and mutational status of telomerase reverse transcriptase in conjunctival squamous cell carcinoma

Indian Journal of Ophthalmology, 2022
Purpose: Mutations in human telomerase reverse transcriptase (TERT) are associated with increased telomerase activity in cutaneous melanomas. Conjunctival squamous cell carcinoma, also referred to as ocular surface squamous cell carcinoma, is cancer on ...
Perumal Jayaraj, Seema Sen, Kartikey Saxena, Jassika Gupta, Pranjal Vats, Seema Kashyap, Sheetal Chauhan, Neelam Pushker   +7 more
doaj   +1 more source

tert-Butoxytriphenylsilane [PDF]

Acta Crystallographica Section E Structure Reports Online, 2010
The title compound, C(22)H(24)OSi or Ph(3)SiO(t)Bu, shows a distorted tetra-hedral coordination sphere around the Si atom. The C-O-Si angle is 135.97 (12)° and the O-Si distance is 1.6244 (13) Å. The mol-ecules are held together by weak inter-actions only. An H⋯H distance of 2.2924 (7) Å is found between aryl H atoms and is the shortest inter-molecular
Jonathan O. Bauer, Carsten Strohmann
openaire   +3 more sources

Iodine avidity in papillary and poorly differentiated thyroid cancer is predicted by immunohistochemical and molecular work-up

European Thyroid Journal, 2023
Background: Successful radioiodine treatment of differentiated thyroid canc er requires iodine avidity: that is, the concentration and retention of iodine in cancer tissue. Several parameters have previously been linked with lower iodine avidity. However,
Joachim N Nilsson, Jonathan Siikanen, Vincenzo Condello, Kenbugul Jatta, Ravi Saini, Christel Hedman, Catharina Ihre Lundgren, C Christofer Juhlin   +7 more
doaj   +1 more source

TERT promoter mutation and proEx C are useful as a screening tool to predict the malignant behavior of thyroid tumors of uncertain malignant potential

Polish Journal of Pathology, 2021
Gray zone thyroid tumors for which benignity or malignancy cannot be assessed are constantly increasing and accurate prediction of their malignant behavior is vital to avoid both violent surgical intervention for benign tumors and lax treatment of ...
Mohamed A. Alabiad, Alsayed A. Alsayed, Ahmed S. Mohamed, Amany M. Shalaby, Yousef Nosery, Mai A. Gobran   +5 more
doaj   +1 more source

Prognostic value of somatic mutation testing and different methods of treatment of low-risk differentiated thyroid cancer [PDF]

Эндокринная хирургия, 2019
Background: Using molecular testing for prediction the course of the disease could possibly help doctors in making therapeutic decisions about the management of patients, because it remains controversial issues in low-risk differentiated thyroid cancer ...
Vera A. Kachko, Vladimir E. Vanushko, Nadezhda M. Platonova   +2 more
doaj   +1 more source

tert-Butylaminium phosphite [PDF]

Acta Crystallographica Section E Structure Reports Online, 2009
In the title compound, C(4)H(12)N(+)·H(2)PO(3) (-), the components are linked by inter-molecular N-H⋯O and O-H⋯O hydrogen bonds, resulting in a two-dimensional framework.
Jian, Fang-Fang, Zhang, Jun-Li
openaire   +3 more sources

Mechanisms of Reactivation and Its Interaction with [PDF]

Endocrinology and Metabolism, 2020
The telomerase reverse transcriptase (TERT) gene, which is repressed in most differentiated human cells, can be reactivated by somatic TERT alterations and epigenetic modulations.
Young Shin Song, Young Joo Park
doaj   +1 more source