Results 181 to 190 of about 367,883 (311)

Type 2 Diabetes From the Perspective of Telomere Biology. [PDF]

Endocrinol Diabetes Metab
Cao H, Feng H, Shen Z, Huang Y.
europepmc   +1 more source

SETD1A Regulates Glycolysis and Senescence of Nucleus Pulposus Cells via H3K4me3–HELZ2/PPARα‐HIF1α Axis to Drive Intervertebral Disc Degeneration

Advanced Science, EarlyView.
SETD1A is a key epigenetic regulator in NPCs during IDD. In normal NPCs, it sustains H3K4me3–HELZ2/PPARα–HIF1α signaling to maintain glycolytic energy metabolism and proliferation. In degenerated NPCs, reduced SETD1A disrupts this axis, impairing glycolysis and accelerating senescence, highlighting a promising therapeutic target for IDD.
Jiawei Fu, Xue Leng, Jiang Long, Zhengao Liao, Xiaoqin An, Xuezheng Ai, Dan Long, Changqing Li, Bo Huang, Yue Zhou, Shiwu Dong, Chencheng Feng   +11 more
wiley   +1 more source

TERT promoter mutations and recurrence patterns in differentiated thyroid carcinoma. [PDF]

Endocr Relat Cancer
Ryu HJ, Yoo JH, Leem DE, Ki CS, Shin JH, Oh YL, Kim JH, Jun JE, Ahn KJ, Ahn J, Kim SW, Chung JH, Kim TH, Son YI.   +13 more
europepmc   +1 more source

Tracing the Dynamic Chemical Transformations of Spiro‐OMeTAD in Operating Perovskite Solar Cells

Advanced Science, EarlyView.
Mapping of Spiro‐OMeTAD layer's chemistry and electronic properties in PSC: Advanced cluster ion‐beam sputtering depth profile XPS reveals that environmental stressors (light, potential, and moisture) trigger the decomposition of LiTFSI dopants in Spiro‐OMeTAD.
Chittaranjan Das, Mayank Kedia, Kenedy Tabah Tanko, Yunshan Wang, Christian Njel, Monica Lira‐Cantu, Michael Saliba   +6 more
wiley   +1 more source

A phosphorous-based dendrimer targets mitochondria and normalizes the keratinocyte proliferation/differentiation balance to improve psoriasis. [PDF]

PLoS One
Clement E, Jebbawi R, Oukhrib A, Labie H, Le Moal M, Fruchon S, Cassel S, Caminade AM, Turrin CO, Blanzat M, Simon M, Poupot R.   +11 more
europepmc   +1 more source

Amines vs. N-Oxides as Organocatalysts for Acylation, Sulfonylation and Silylation of Alcohols: 1-Methylimidazole N-Oxide as an Efficient Catalyst for Silylation of Tertiary Alcohols [PDF]

, 2015
Murray, JI, Spivey, AC
core   +1 more source

Substrate‐Affinitive P‐Type Azapolycyclic Photosensitizer for Chemoselective Nitrilization Under Mild Conditions

Advanced Science, EarlyView.
We developed a series of quinoxalinoquinoxaline (QQ) photosensitizers featuring high and tunable excited‐state reduction potentials (E(PC•+/PC*) = –1.76 to –2.05 V vs. SCE). Their hydrogen‐bonding interaction with carbonyl substrates enables selective single‐electron transfer events for selective nitrilization of 1° amides, offering a tunable ...
Seongwoo Bae, Dongwook Kim, Jinwoo Kim
wiley   +1 more source

Predictive Factors for Distant Metastasis in Follicular Thyroid Carcinoma: Analysis of Clinical, Genetic, and Radiomics Features. [PDF]

J Korean Soc Radiol
Yang D, Hwang I, Ham T, Lee JY, Kim JH, Won JK.   +5 more
europepmc   +1 more source

Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell Ferroptosis Through GSK3β Dependent Ubiquitin‐Mediated NRF2 Degradation

Advanced Science, EarlyView.
Lipid metabolic stress triggers ferroptosis in PDLSCs through the GSK3β/NRF2 pathway, thereby aggravating periodontal bone loss. Upregulated GSK3β promotes NRF2 ubiquitination and proteasomal degradation via β‐TrCP, suppressing NRF2 nuclear translocation and antioxidant target expression.
Yuxiao Zhang, Xiangyao Wang, Yaxin Wu, Liping Liu, Gaoshaer Nuerlan, Ahsawle Ozathaley, Xiaorui Zhang, Jinping Wang, Bowen Yang, Jing Mao, Yan Liu, Shiqiang Gong   +11 more
wiley   +1 more source

Lidocaine inhibits hepatocellular carcinoma cell proliferation, migration, and invasion through the downregulation of SLC6A3. [PDF]

Sci Rep
Li P, Tong W, He H, Liu H, Yang X.
europepmc   +1 more source