Results 171 to 180 of about 203,484 (292)

Lipid Metabolic Dysregulation Driven by OSMR Mutations Underlies Amyloidogenesis in Primary Localized Cutaneous Amyloidosis

Advanced Science, EarlyView.
OSMR mutations disrupt STAT5 signaling and AKR1B10‐mediated lipid metabolism, leading to lipid accumulation and protein aggregation in keratinocytes. This metabolic reprogramming drives amyloid deposition in primary localized cutaneous amyloidosis, revealing a mechanistic link between lipid dysregulation and amyloidogenesis.
Huiting Liu, Wen Zheng, Chao Yang, Tao Yang, Qiuyu Chen, Ping Lu, Huan Yang, Jun Liu, Bin Yang   +8 more
wiley   +1 more source

Comprehensive In Silico Analysis Identifies MSTO1 and LIG1 as Candidate Biomarkers With Diagnostic and Prognostic Relevance in Hepatocellular Carcinoma. [PDF]

Cancer Rep (Hoboken)
Hamad J, Fayyad-Kazan H, Abdel-Sater F.
europepmc   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Association between autoimmune thyroiditis and BRAFV600E/TERT promoter mutations in patients with papillary thyroid carcinoma from Central Asia, Kazakhstan. [PDF]

PLoS One
Kaidarova S, Mussazhanova Z, Kozykenova Z, Kurohama H, Targynova A, Dyussupov A, Yeleubayeva Z, Nakashima M.   +7 more
europepmc   +1 more source

Phosphine Coordination to Ce, Nd, Np, and Pu in ArBiAMPtBu‐Supported Complexes and Their 2H and 13C Isotopologues

Advanced Science, EarlyView.
A dianionic ligand designed to encourage metal‐phosphine coordination—bis((3,5‐dimethylphenyl)amidomethyl)tertbutylphosphine (ArBiAMPtBu)—was employed in the synthesis of paramagnetic complexes of Ce, Nd, Np, and Pu, producing MI(ArBiAMPtBu)(thf)3.
Novan A. G. Gray, Yury Minko, Brenna K. Cashman, R. Joseph Lastowski, Adam R. Altenhof, Harris E. Mason, Daniel J. Lussier, Frank MacGregor, Andrew J. Gaunt, Aaron M. Tondreau   +9 more
wiley   +1 more source

A Biomimetic Solvatochromic Chip With Optimized Chemical Diversity for On‐Site Liquid Identification

Advanced Science, EarlyView.
A compact biomimetic photonic‐gustatory chip uses Hansen‐solubility‐parameter‐guided solvatochromic disks to create distinct color patterns in organic liquids. An optimized four‐disk array distinguishes solvent types, ratios, homologues, isomers, and alcoholic beverages. Coupled with smartphone imaging and deep learning, it identifies 80 liquid classes
Jintao Zhang, Hao Ouyang, Yin Cheng, Nuoye Xiong, Xunchi Ma, Xueling Li, Guangming Zhu, Liang Zhang, Jing Sun, Ranran Wang   +9 more
wiley   +1 more source

Prognostic Role of TERT Mutations in Chondrosarcoma: Associations with Dedifferentiation, Survival, and IDH/TERT Co-Mutations. [PDF]

Cancers (Basel)
Zafar A, Ference D, Crawford BM, Fitz SJT, Hornicek FJ, Temple HT.   +5 more
europepmc   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

USP10 stabilizes FOXM1 through KAT5-mediated acetylation to suppress cell senescence and promote melanoma malignant progression. [PDF]

Int J Biol Sci
Qiu Z, Sun C, Wang J, Liang D, Wang S, Tian L, Du T, Han C.   +7 more
europepmc   +1 more source

Sequence‐Controlled Copolymers Through Selective Ring‐Opening Polymerization of Multiunit Macrolactones

Advanced Science, EarlyView.
Sequence‐controlled polymers were prepared through ring‐opening polymerization (ROP) exploiting esters with enhanced reactivity in the multiunit monomer induced by incorporation of a glycolate group, enabling selective ROP. ABSTRACT A new strategy for the synthesis of sequence‐controlled polymers (SCP), in which increased ester reactivity by the ...
Vincent Nieboer, Giacomo Di Giambattista, Peter Olsén, Peter Dinér, Karin Odelius   +4 more
wiley   +1 more source