Results 31 to 40 of about 126,726 (160)
Molecular Oncology, 2021 Telomerase reverse transcriptase (TERT) maintains telomere homeostasis, thus ensuring chromosome stability and cell proliferation. In addition, several telomere‐independent functions of human TERT have been described.
Manuel Bernabé‐García +8 more
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PLoS Genetics, 2019 Telomerase, particularly its main subunit, the reverse transcriptase, TERT, prevents DNA erosion during eukaryotic chromosomal replication, but also has poorly understood non-canonical functions. Here, in the model social amoeba Dictyostelium discoideum,
Nasna Nassir +2 more
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Quiescence Exit of Tert+ Stem Cells by Wnt/β-Catenin Is Indispensable for Intestinal Regeneration
Cell Reports, 2017 Fine control of stem cell maintenance and activation is crucial for tissue homeostasis and regeneration. However, the mechanism of quiescence exit of Tert+ intestinal stem cells (ISCs) remains unknown. Employing a Tert knockin (TertTCE/+) mouse model, we
Han Na Suh +5 more
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PIF1 Affects the Proliferation and Apoptosis of Cervical Cancer Cells by Influencing TERT
Cancer Management and Research, 2020 Jiancai Wang,1,* Xiaoyan Zhu,1,* Pian Ying,2 Yingping Zhu2 1Department of Gynaecology and Obstetrics, Jianhu Hospital Affiliated to Nantong University, Yancheng, Jiangsu 224700, People’s Republic of China; 2Department of Obstetrics and Gynecology ...
Wang J, Zhu X, Ying P, Zhu Y
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BMC Genomics, 2012 Background The TERT gene encodes the catalytic subunit of the telomerase complex and is responsible for maintaining telomere length. Vertebrate telomerase has been studied in eutherian mammals, fish, and the chicken, but less attention has been paid to ...
Hrdličková Radmila +4 more
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Targeting the NCOA3-SP1-TERT axis for tumor growth in hepatocellular carcinoma
Cell Death and Disease, 2020 Hepatocellular carcinoma (HCC) has a high mortality rate and lacks an effective therapeutic target. Elevated expression of human telomerase reverse transcriptase (TERT) is an important hallmark in cancers, but the mechanism by which TERT is activated ...
Wenbin Li +12 more
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TERT promoter mutations lead to high transcriptional activity under hypoxia and temozolomide treatment and predict poor prognosis in gliomas. [PDF]
PLoS ONE, 2014 This study explored the effects of telomerase reverse transcriptase (TERT) promoter mutations on transcriptional activity of the TERT gene under hypoxic and temozolomide (TMZ) treatment conditions, and investigated the status and prognostic value of ...
Chen Chen +5 more
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Notizen: Di-tert-butylchlorthioarsoran / Di-tert-butylchlorothioarsorane
Zeitschrift für Naturforschung B, 1976 The preparation of the first chlorodiorganylthioarsorane is reported. Amidodi(tertbutyl)arsine and sulfur react to give amidodi(tert-butyl)thioarsorane, which is converted into chlorodi(tert-butyl)thioarsorane by a solution of HCl in ether. Some reactions of chlorodi(tert-butyl)thioarsorane are described.
B. Ross, W. Marzi, G. Wilhelm
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Clinical and Translational Medicine, 2022 Background Telomerase is a ribonucleoprotein complex consisting of a catalytic component telomerase reverse transcriptase (TERT), internal RNA template and other co‐factors, and its essential function is to synthesize telomeric DNA, repetitive TTAGGG ...
Xiaotian Yuan +4 more
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Endocrine ConnectionsPapillary thyroid carcinoma (PTC) is the most prevalent histological subtype of thyroid cancer. However, it remains unclear whether BRAFV600E, TERT promoter (TERT-p), and certain pathological markers, such as loss of polarity/loss of cell cohesiveness ...
Nguyen Thi Nhung +9 more
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