Results 41 to 50 of about 126,726 (160)

TERT—Regulation and Roles in Cancer Formation

Frontiers in Immunology, 2020
Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase. Telomerase complex plays a key role in cancer formation by telomere dependent or independent mechanisms.
Marta Dratwa, Barbara Wysoczańska, Piotr Łacina, Tomasz Kubik, Katarzyna Bogunia-Kubik   +4 more
doaj   +1 more source

Accumulation of TERT in mitochondria exerts two opposing effects on apoptosis

FEBS Open Bio, 2023
Telomerase reverse transcriptase (TERT) is a protein that catalyzes the reverse transcription of telomere elongation. TERT is also expected to play a non‐canonical role beyond telomere lengthening since it localizes not only in the nucleus but also in ...
Hiroshi Ebata, Tomohiro Shima, Ryo Iizuka, Sotaro Uemura   +3 more
doaj   +1 more source

Oncolytic Adenovirus RCA-TERT-Ad35 Carrying Human Telomerase Reverse Transcriptase Promoter Targets Breast Cancer Stem Cells

Zhongliu Fangzhi Yanjiu, 2019
Objective To investigate the role of oncolytic adenovirus RCA-TERT-Ad35 carrying human telomerase reverse transcriptase promoter in targeting breast cancer stem cells.
WANG Weichuan, CHEN Lulu, QUAN Xianglan, LI Ying, JIN Yongmin, JIN Wenbiao, YU Kexin, ZHANG Songnan   +7 more
doaj   +1 more source

Synergistic activation of mutant TERT promoter by Sp1 and GABPA in BRAFV600E-driven human cancers

npj Precision Oncology, 2021
The activating TERT promoter mutations and BRAF V600E mutation are well-established oncogenic alterations in human cancers. Coexistence of BRAF V600E and TERT promoter mutations is frequently found in multiple cancer types, and is strongly associated ...
Yongxing Wu, Liang Shi, Yuelei Zhao, Pu Chen, Rongrong Cui, Meiju Ji, Nongyue He, Maode Wang, Gang Li, Peng Hou   +9 more
doaj   +1 more source

Telomeres control human telomerase (TERT) expression through non-telomeric TRF2

eLife
The function of the human telomerase reverse transcriptase (referred hereafter as TERT) in the synthesis and maintenance of chromosome ends, or telomeres, is widely understood.
Antara Sengupta, Soujanya Vinayagamurthy, Dristhi Soni, Rajlekha Deb, Ananda Kishore Mukherjee, Subhajit Dutta, Jushta Jaiswal, Mukta Yadav, Shalu Sharma, Sulochana Bagri, Shuvra Shekhar Roy, Priya Poonia, Ankita Singh, Divya Khanna, Amit Kumar Kumar Bhatt, Akshay Sharma, Suman Saurav, Rajender K Motiani, Shantanu Chowdhury   +18 more
doaj   +1 more source

1-tert-Butyl-2-(tert-butylaminomethylidene)-3-pyrrolidinone, C13H24N2O [PDF]

Acta Crystallographica Section C Crystal Structure Communications, 1994
The eneamine moiety on the pyrrolidinone rig is coplanar to the carbonyl function, with an E configuration stabilized by an intramolecular N-H...O ...
Koten, G. van, Janssen, M.D., Wissing, E., Spek, A.L.   +3 more
openaire   +2 more sources

Expression of the Reverse Transcriptase Domain of Telomerase Reverse Transcriptase Induces Lytic Cellular Response in DNA-Immunized Mice and Limits Tumorigenic and Metastatic Potential of Murine Adenocarcinoma 4T1 Cells

Vaccines, 2020
Telomerase reverse transcriptase (TERT) is a classic tumor-associated antigen overexpressed in majority of tumors. Several TERT-based cancer vaccines are currently in clinical trials, but immune correlates of their antitumor activity remain largely ...
Juris Jansons, Ekaterina Bayurova, Dace Skrastina, Alisa Kurlanda, Ilze Fridrihsone, Dmitry Kostyushev, Anastasia Kostyusheva, Alexander Artyuhov, Erdem Dashinimaev, Darya Avdoshina, Alla Kondrashova, Vladimir Valuev-Elliston, Oleg Latyshev, Olesja Eliseeva, Stefan Petkov, Maxim Abakumov, Laura Hippe, Irina Kholodnyuk, Elizaveta Starodubova, Tatiana Gorodnicheva, Alexander Ivanov, Ilya Gordeychuk, Maria Isaguliants   +22 more
doaj   +1 more source

Age-associated mortality is partially mediated by TERT promoter mutation status in differentiated thyroid carcinoma.

PLoS ONE, 2023
BackgroundAge at diagnosis (AAD) and telomerase reverse transcriptase (TERT) promoter mutations are prognostic factors in differentiated thyroid carcinoma (DTC), and the prevalence of the mutations increases with AAD.
Jung Heo, Sungjoo Lee, Jun Park, Heera Yang, Hyunju Park, Chang-Seok Ki, Young Lyun Oh, Hye In Kim, Sun Wook Kim, Jae Hoon Chung, Kyunga Kim, Tae Hyuk Kim   +11 more
doaj   +1 more source

4-tert-Butylpyridinium picrate [PDF]

Acta Crystallographica Section E Structure Reports Online, 2010
In the title compound, C(9)H(14)N(+)·C(6)H(2)N(3)O(7) (-), the three nitro groups of the picrate anion are twisted out of the plane of the attached benzene ring; the dihedral angles are 32.8 (2), 10.5 (4) and 12.3 (4)°. The pyridinium cations and picrate anions are linked via bifurcated N-H⋯(O,O) hydrogen bonds. The ionic pairs are linked into a ribbon-
P. Ramesh, R. Akalya, A. Chandramohan, M. N. Ponnuswamy   +3 more
openaire   +3 more sources

An efficient and highly selective ortho-tert-butylation of p-cresol with methyl tert-butyl ether catalyzed by sulfonated ionic liquids [PDF]

Journal of the Serbian Chemical Society, 2014
A novel series of sulfonic acid-functionalized ionic liquids (SFILs) was found to act as efficient catalysts for ortho-tert-butylation of p-cresol with methyl tert-butyl ether (MTBE) as the tert-butylating agent without an added solvent.
Alamdari Reza Fareghi, Zamani Faezeh Ghorbani, Zekri Negar   +2 more
doaj   +1 more source