Results 51 to 60 of about 126,726 (160)

Pan-cancer experimental characteristic of human transcriptional patterns connected with telomerase reverse transcriptase (TERT) gene expression status

Frontiers in Genetics
The TERT gene encodes the reverse transcriptase subunit of telomerase and is normally transcriptionally suppressed in differentiated human cells but reactivated in cancers where its expression is frequently associated with poor survival prognosis.
Aleksey Drobyshev, Aleksey Drobyshev, Alexander Modestov, Maria Suntsova, Maria Suntsova, Elena Poddubskaya, Elena Poddubskaya, Alexander Seryakov, Aleksey Moisseev, Maksim Sorokin, Maksim Sorokin, Victor Tkachev, Galina Zakharova, Aleksander Simonov, Marianna A. Zolotovskaia, Marianna A. Zolotovskaia, Marianna A. Zolotovskaia, Anton Buzdin, Anton Buzdin, Anton Buzdin, Anton Buzdin   +20 more
doaj   +1 more source

TERT upstream promoter methylation regulates TERT expression and acts as a therapeutic target in TERT promoter mutation-negative thyroid cancer

Cancer Cell International
Background DNA hypermethylation and hotspot mutations were frequently observed in the upstream and core promoter of telomerase reverse transcriptase (TERT), respectively, and they were associated with increased TERT expression and adverse clinical ...
Shiyong Li, Guanghui Hu, Yulu Chen, Ye Sang, Qin Tang, Rengyun Liu   +5 more
doaj   +1 more source

Hippocampal TERT Regulates Spatial Memory Formation through Modulation of Neural Development

Stem Cell Reports, 2017
Summary: The molecular mechanism of memory formation remains a mystery. Here, we show that TERT, the catalytic subunit of telomerase, gene knockout (Tert−/−) causes extremely poor ability in spatial memory formation.
Qi-Gang Zhou, Meng-Ying Liu, Han-Woong Lee, Fuyuki Ishikawa, Sushil Devkota, Xin-Ru Shen, Xin Jin, Hai-Yin Wu, Zhigang Liu, Xiao Liu, Xun Jin, Hai-Hui Zhou, Eun Jeoung Ro, Jing Zhang, Yu Zhang, Yu-Hui Lin, Hoonkyo Suh, Dong-Ya Zhu   +17 more
doaj   +1 more source

Discovery and characterization of a novel telomerase alternative splicing isoform that protects lung cancer cells from chemotherapy induced cell death

Scientific Reports
All cancer cells must adopt a telomere maintenance mechanism to achieve replicative immortality. Most human cancer cells utilize the enzyme telomerase to maintain telomeres.
Jeongjin J. Kim, Alexander Ahn, Jeffrey Y. Ying, Andrew T. Ludlow   +3 more
doaj   +1 more source

Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT Genes

Cell Reports, 2017
A mutation in the promoter of the Telomerase Reverse Transcriptase (TERT) gene is the most frequent noncoding mutation in cancer. The mutation drives unusual monoallelic expression of TERT, allowing immortalization.
Josh Lewis Stern, Richard D. Paucek, Franklin W. Huang, Mahmoud Ghandi, Ronald Nwumeh, James C. Costello, Thomas R. Cech   +6 more
doaj   +1 more source

Lithio-di-tert-butylfluorsilyl-tert-butylphosphan — Kristallstruktur und Reaktionen/Lithio-di-tert-butylfluorosilyl-tert-butylphosphane — Crystal Structure and Reactions

Zeitschrift für Naturforschung B, 1989
Abstract Di-tert-butylfluorosilyl-tert-butylphosphane (1) reacts with n-C4H9Li to give the lithium salt (CMe3)2SiF-PLi(THF)3CMe3 (2) and butane. The crystal structure of 2 has been determined. Fluorosilylphosphanes of the type (CMe3)2SiFP(R)CMe3 [R = SiMe3 (5), SiCl2Me (6).
Mbolatiana Andrianarison, Uwe Klingebiel
openaire   +1 more source

Therapeutic targeting of PLK1 in TERT promoter‐mutant hepatocellular carcinoma

Clinical and Translational Medicine
Background Hotspot mutations in the promoter of telomerase reverse transcriptase (TERT) gene are the most common genetic variants in hepatocellular carcinoma (HCC) and associated with poor prognosis of the disease. However, no drug was currently approved
Qin Tang, Guanghui Hu, Ye Sang, Yulu Chen, Guangyan Wei, Meiyan Zhu, Mengke Chen, Shiyong Li, Rengyun Liu, Zhenwei Peng   +9 more
doaj   +1 more source

Histopathology of telomerase reverse transcriptase promoter (TERT) mutated indeterminate thyroid nodules

Journal of Clinical & Translational Endocrinology
Objective: The objective of this study was to analyze the risk of malignancy and the histopathology of telomerase reverse transcriptase promoter (TERT) mutated cytologically indeterminate thyroid nodules (ITN).
Jessica O. Pinto, Masha J. Livhits, Michael W. Yeh, Atanas Kaykov, Joshua P. Klopper, Richard T. Kloos, Mohammed Alshalalfa, Yangyang Hao, Jing Huang, Mayumi Endo   +9 more
doaj   +1 more source

TERT promoter methylation is associated with high expression of TERT and poor prognosis in papillary thyroid cancer

Frontiers in Oncology
The telomerase reverse transcriptase (TERT) is overexpressed and associated with poor prognosis in papillary thyroid cancer (PTC), the most common subtype of thyroid cancer.
Shiyong Li, Junyu Xue, Ke Jiang, Yulu Chen, Lefan Zhu, Rengyun Liu   +5 more
doaj   +1 more source

The regulations of telomerase reverse transcriptase (TERT) in cancer

Cell Death and Disease
Abnormal activation of telomerase occurs in most cancer types, which facilitates escaping from cell senescence. As the key component of telomerase, telomerase reverse transcriptase (TERT) is regulated by various regulation pathways. TERT gene changing in
Mingdi Liu, Yuning Zhang, Yongping Jian, Liting Gu, Dan Zhang, Honglan Zhou, Yishu Wang, Zhi-Xiang Xu   +7 more
doaj   +1 more source