Results 131 to 140 of about 11,725 (256)

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

Tertiary Lymphoid Structure-Like Lymphocyte Aggregate Generation in Human and Mouse Hypokalaemic Nephropathy: Research Letter. [PDF]

Can J Kidney Health Dis
Komada T, Komori S, Karasawa T, Morishita Y, Fukushima N, Nagata D, Takahashi M.   +6 more
europepmc   +1 more source

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source

The value of tertiary lymphoid structure on predicting the survival rate of advanced cervical cancer patients. [PDF]

BMC Cancer
Huang S, Wu S, Li Y, Lin Y, Chang X, Yi X, Long Y, Liu C.   +7 more
europepmc   +1 more source

Myasthenia Gravis and Thymoma

Muscle &Nerve, EarlyView.
ABSTRACT Thymoma is the most common tumor of the anterior mediastinum. Approximately 20%–30% of patients with a thymoma develop myasthenia gravis (MG), and an additional one third may possess positive acetylcholine receptor (AChR) antibodies without MG.
Benjamin Claytor, Lukas Delasos, Daniel P. Raymond, Erik Seroogy, Jason Lempel, Yuebing Li   +5 more
wiley   +1 more source

Correction: The clinical and pathological significance of tertiary lymphoid structure in extramammary Paget's disease. [PDF]

Front Immunol
Xi N, Xu X, Xu M, Wu N, Wu Y, Chen J, Liu S, Jiang L, Yan G, Zhang G, Liu Y.   +10 more
europepmc   +1 more source

Ineffectiveness of immune checkpoint inhibitors in prostate cancer: is it just a question of ‘‐mabs’?

The Journal of Pathology, EarlyView.
Abstract Prostate cancer (PCa) is the second most common type of neoplasm, currently treated with a variety of therapeutic agents. Although advances in treatment over the past decade have improved overall survival, patients with advanced PCa eventually progress from hormone‐sensitive PCa to metastatic castration‐resistant PCa.
Giuseppe Schepisi, Irene Torresan, Emilio Francesco Giunta, Sara Bleve, Nicole Brighi, Elisa Tassinari, Sofia Zanuccoli, Maria Concetta Cursano, Cristian Lolli   +8 more
wiley   +1 more source

Synergistic effects and clinical utilization of radioimmunotherapy for brain metastases from driver mutation‐negative non‐small cell lung cancer

Precision Radiation Oncology, EarlyView.
This review summarizes how combining radiotherapy with immune checkpoint inhibitors overcomes the immunosuppressive brain microenvironment in non‐small cell lung cancer (NSCLC) brain metastases. The synergy enhances immune cell infiltration and systemic anti‐tumor activity, improving survival outcomes for patients.
Silai Yu, Jianjiao Ni, Hongru Chen, Nuan Weng, Xi Yang, Xiao Chu, Li Chu, Zhengfei Zhu   +7 more
wiley   +1 more source

Research progress of tertiary lymphoid structure in hepatocellular carcinoma: from prognostic biomarkers to new strategies for immunotherapy. [PDF]

Front Immunol
Yuan S, Luo X, Li S, Cao L, Chen X, Wang L, Liu Y, Li Z, Wu T, Fang H, Tong M.   +10 more
europepmc   +1 more source

Granzyme K: A new frontier in systemic lupus erythematosus

Rheumatology &Autoimmunity, EarlyView.
The role of Granzyme K in the pathogenesis of systemic lupus erythematosus and its clinical translational significance. Abstract Systemic lupus erythematosus (SLE) is a complex autoimmune disorder driven by dysregulated adaptive and innate immunity and aberrant complement activity.
Zhongyu Chen, Yunjing Pu, Peihui Yang, Qinghuan Zhu, Haojun Long, Danqi Deng   +5 more
wiley   +1 more source