Results 151 to 160 of about 7,278,692 (246)

The Enteric Nervous System: An Integrative Hub From Development to Systemic Physiology

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
Unlike a static hardwired circuit, the ENS continuously remodels its transcriptional programs and synaptic connectivity in response to three ecological forces: microbial metabolites, immune cell signals and enteroendocrine cues. ABSTRACT The enteric nervous system (ENS) constitutes the largest and most functionally autonomous subdivision of the ...
Mario Cuchillo‐Hilario, Margarita Díaz‐Martínez, Mario Alberto Viazcan‐Carbajal, Victor David González‐Fernández   +3 more
wiley   +1 more source

Tertiary Lymphoid Structure-Like Lymphocyte Aggregate Generation in Human and Mouse Hypokalaemic Nephropathy: Research Letter. [PDF]

Can J Kidney Health Dis
Komada T, Komori S, Karasawa T, Morishita Y, Fukushima N, Nagata D, Takahashi M.   +6 more
europepmc   +1 more source

Bee pollen as functional food and environmental bioindicator: current evidence and future challenges

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Bee pollen (BP), a plant‐derived product collected by honey bees, is increasingly promoted as a functional food due to its content of proteins, essential amino acids, lipids, vitamins, minerals, and bioactive compounds such as polyphenols and flavonoids.
Luigi Parrotta, Stefano Del Duca
wiley   +1 more source

Cancer-associated fibroblasts and tertiary lymphoid structure orchestrate the spatial architecture of tumor immunity. [PDF]

J Hematol Oncol
Tang H, Shi Y, Ge Q, Wang R, Yang J, Zhu Y, Liu S, Xu W.   +7 more
europepmc   +1 more source

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

SIRT1 Inhibits T-cell Infiltration and Tertiary Lymphoid Structure Formation to Promote Radioimmunotherapy Resistance. [PDF]

Cancer Res
Shi Y, Wu ZF, Liu S, Wan T, Luo R, Liu H, Zeng Z, Li W, Liang Z, Xiong L, Luo S, Yuan Y, Huang L, Kang L.   +13 more
europepmc   +1 more source

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source

Correction: The clinical and pathological significance of tertiary lymphoid structure in extramammary Paget's disease. [PDF]

Front Immunol
Xi N, Xu X, Xu M, Wu N, Wu Y, Chen J, Liu S, Jiang L, Yan G, Zhang G, Liu Y.   +10 more
europepmc   +1 more source

Organoid Coculture Models for Cancer Research and Immunotherapy

Med Research, EarlyView.
This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen   +9 more
wiley   +1 more source

GCUNet: a graph neural network-based contextual learning network for tertiary lymphoid structure semantic segmentation in whole slide image. [PDF]

Vis Comput Ind Biomed Art
Su L, Li R, Zhang G, Liu Z, Geng X, Wang H, Gai W, Wu H, Tian J, Du Y.   +9 more
europepmc   +1 more source