Results 171 to 180 of about 11,902 (192)
Some of the next articles are maybe not open access.
Tertiary Lymphoid Structures Among the World of Noncanonical Ectopic Lymphoid Organizations
2018Tertiary lymphoid structures (TLOs), also known as ectopic lymphoid structures, are associated with chronic infections and inflammatory diseases. Despite their association with pathology, these structures are actually a normal, albeit transient, component of the immune system and facilitate local immune responses that are meant to mitigate inflammation
Aaron, Silva-Sanchez +2 more
openaire +2 more sources
Tertiary Lymphoid Structures: Allies of Cancer Immunotherapy
ImmunologyABSTRACTImmunotherapy has demonstrated groundbreaking clinical efficacy across diverse cancer types. Nevertheless, its therapeutic potential remains constrained, with only a small subset of patients achieving durable clinical responses. Emerging evidence highlights tertiary lymphoid structures (TLSs), ectopic lymphoid aggregates induced by chronic ...
Xinze Li +6 more
openaire +2 more sources
Molecular and Cellular Requirements for the Assembly of Tertiary Lymphoid Structures
2018At sites of chronic inflammation, recruited immune cells form structures that resemble secondary lymphoid organs (SLOs). Those are characterized by segregated areas of prevalent T- or B-cell aggregation, differentiation of high endothelial venules (HEVs) and local activation of resident stromal cells.
C G, Mueller +3 more
openaire +2 more sources
The Evolving Landscape of Bladder Tertiary Lymphoid Structures
Journal of Urology, 2023Madhuri, Koti, D Robert, Siemens
openaire +2 more sources
Tertiary lymphoid structures as hubs of antitumour immunity
Nature Reviews Cancer, 2023Gabriela Sarti Kinker +1 more
openaire +2 more sources
Meningeal Immunity, Drainage, and Tertiary Lymphoid Structure Formation
2018For decades, the brain has been considered an immune-privileged organ, meaning that the brain was mainly ignored by the immune system and that the presence of immune cells, notably of the adaptive arm, was a hallmark of pathological conditions. Over the past few decades, the definition of the immune privilege continues to be refined.
openaire +2 more sources
Tertiary Lymphoid Structures and Immunotherapy: Challenges and Opportunities
Tertiary lymphoid structures (TLS) are accumulations of lymphoid cells that arise in ectopic sites through the process of lymphoid neogenesis in chronic inflammation in autoimmunity, microbial infections, organ rejection, aging, and cancer. Their cellular composition and function and regulation via members of the lymphotoxin (LT)/tumor necrosis factor (openaire +2 more sources