Results 181 to 190 of about 25,496 (206)

An Introduction to Tertiary Lymphoid Structures in Cancer

Immunotherapy has revolutionized therapeutics for cancer patients, which signifies the importance of effective antitumor immunity in combatting cancer. However, the benefit of immunotherapies is limited to specific patient populations and tumor types, suggesting the overt need for new immunotherapeutic targets.
Hye Mi, Kim, Tullia C, Bruno
openaire   +2 more sources

Tertiary Lymphoid Structures in Central Nervous System Disorders

The central nervous system (CNS) constitutes a tightly regulated milieu, where immune responses are strictly controlled to prevent neurological damage. This poses considerable challenges to the therapeutic management of CNS pathologies, such as autoimmune disorders and cancer.
Alessandra, Vaccaro, Beatriz, de Alves Pereira, Tiarne, van de Walle, Anna, Dimberg   +3 more
openaire   +2 more sources

Tertiary Lymphoid Structures: Allies of Cancer Immunotherapy

Immunology
ABSTRACTImmunotherapy has demonstrated groundbreaking clinical efficacy across diverse cancer types. Nevertheless, its therapeutic potential remains constrained, with only a small subset of patients achieving durable clinical responses. Emerging evidence highlights tertiary lymphoid structures (TLSs), ectopic lymphoid aggregates induced by chronic ...
Xinze Li, Xinnan Zhang, Zhiyong Cao, Jianhua Guan, Feng Qiu, Qiang Zhang, Ning Kang   +6 more
openaire   +1 more source

The Evolving Landscape of Bladder Tertiary Lymphoid Structures

Journal of Urology, 2023
Madhuri, Koti, D Robert, Siemens
openaire   +2 more sources

TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures

Immunity, 2022
Ricardo A Chaurio, Carmen M Anadon, Tara Lee Costich   +2 more
exaly  

Microbiota-specific T follicular helper cells drive tertiary lymphoid structures and anti-tumor immunity against colorectal cancer

Immunity, 2021
Abigail E Overacre, Anthony R Cillo, Amrita Bhattacharjee   +2 more
exaly  

Tertiary Lymphoid Structures and Immunotherapy: Challenges and Opportunities

Tertiary lymphoid structures (TLS) are accumulations of lymphoid cells that arise in ectopic sites through the process of lymphoid neogenesis in chronic inflammation in autoimmunity, microbial infections, organ rejection, aging, and cancer. Their cellular composition and function and regulation via members of the lymphotoxin (LT)/tumor necrosis factor (
openaire   +2 more sources

Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing plasma cells in renal cell cancer

Immunity, 2022
Maxime Meylan, Florent Petitprez, Guilhem Pupier   +2 more
exaly  

Tertiary lymphoid structures in malignant melanoma

Chinese Journal of Dermatology, 2021
openaire   +1 more source

S1842 Tertiary Lymphoid Structure Mimicking Pancreatic Mass

American Journal of Gastroenterology, 2022
Marcel R. Robles, Michael Malkowski, Sandeep Krishnan   +2 more
openaire   +1 more source